Comparison of Lidocaine and Atropine on Fentanyl-Induced Cough: A Randomized Controlled Study

Naldan, Muhammet Emin; Arslan, Zakir; Ay, Ayşenur; Yayık, Ahmet Murat

doi:10.1080/08941939.2018.1424272

Cited by 9 publications

(8 citation statements)

References 18 publications

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“…These receptors are irritated by opioids; thus, tracheal smooth muscle is stimulated to be constricted [20]. Sufentanil-induced histamine release from lung mast cells [19]or supraglottic obstruction by soft tissue [21,22] represent other likely mechanisms of cough. A study demonstrated that the closure of the vocal cord after injecting sufentanil may be the major mechanism of cough [23].…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Comparison of a small dose of oxycodone and sufentanil for the prevention of sufentanil-induced cough during general anesthesia induction: a prospective randomized controlled trial

Shi

2021

Preprint

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Background: Sufentanil is widely used during anesthesia induction. However, sufentanil injections can cause cough through different mechanisms. This study aimed to evaluate the effectiveness of a small dose of oxycodone and sufentanil in suppressing sufentanil-induced cough (SIC) during general anesthesia induction.Methods: This prospective, randomized, controlled trial was conducted form February 12, 2019 to December 30, 2019. A total of 174 patients were scheduled for elective surgery, and 144 screened patients were randomly divided into 3 groups (n=48). Five minutes before sufentanil bolus (0.4 μg/kg), patients in group O received 0.02 mg/kg oxycodone intravenously within 5 s, those in group S received 0.02 μg/kg sufentanil within 5 s and those in group N received an equal volume of 0.9% normal saline within 5 s. Sufentanil was diluted to 5 μg/ml and administered within 5 s after pretreatment. The incidence and severity of cough in the three groups were evaluated within 1 minute after sufentanil injection during anesthesia induction. Mean arterial pressure (MAP) and heart rate (HR) were recorded at T0 (after entering the operation), T1 (3 minutes after pretreatment), T2 (before intubation), and T3 (1 minute after intubation).Results: The incidences of cough in group N, group O, and group S were 20 (41.6%), 7 (14.5%), and 6 (12.5%), respectively. Compared with group N, group O and group S exhibited significantly reduced incidence and severity of cough, and the severity of cough in group O and group S was dramatically reduced compared with that in group N (P<0.05). No significant differences in the rangeability of MAP and HR were noted at the four time points in the three groups (P> 0.05).Conclusion: Intravenous oxycodone (0.02 mg/kg) and sufentanil (0.02 μg/kg) represent effective approaches to reducing SIC in anesthesia induction and ensuring a relatively stable hemodynamic state during general anesthesia induction.Trial registration: Chinese Clinical Trial Registry (ChiCTR1900021087, registered date: January 28, 2019), http://www.chictr.org.cn

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Comparison of a small dose of oxycodone and sufentanil for the prevention of sufentanil-induced cough during general anesthesia induction: a prospective randomized controlled trial

Shi

2021

Preprint

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“…However, this hypothesis is controversial, some studies have found that pre-administration of anticholinergic drugs such as atropine cannot reduce the incidence of FIC ( Lui et al, 1996 ). While resent study showed that atropine administered in the preoperative period is as effective as lidocaine in preventing FIC ( Naldan et al, 2019 ).…”

Section: Mechanism Of Fentanyl-induced Coughmentioning

confidence: 99%

Mechanism and Management of Fentanyl-Induced Cough

et al. 2020

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Fentanyl-induced cough (FIC) often occurs after intravenous bolus administration of fentanyl analogs during induction of general anesthesia and analgesia procedure. The cough is generally benign, but sometimes it causes undesirable side effects, including elevated intra-abdominal, intracranial or intraocular pressure. Therefore, understanding the related mechanisms and influencing factors are of great significance to prevent and treat the cough. This paper reviews the molecular mechanism, influencing factors and preventive administration of FIC, focusing on the efficacy and side effects of various drugs in inhibiting FIC to provide some medical reference for anesthesiologists.

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“…Numerous pharmacological or non-pharmacological measures have been taken to prevent OIC. Therein, nonpharmacological measures are characterized by diluting drug concentration, slowing down injection rate, using the peripheral injection site, reducing the drug dose, instructing patients on performing the huffing maneuver, and verifying the proper administration sequence of the drug (Ambesh et al, 2010;Min et al, 2012;Shrestha et al, 2012;Xiong et al, 2020). Currently, pharmacological interventions have been widely used in the clinical setting, including lidocaine, dezocine, dexmedetomidine, ketamine, and butorphanol (Shuying et al, 2016;Zhang et al, 2018;Clivio et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Five Prophylactically Intravenous Drugs in Preventing Opioid-Induced Cough: A Bayesian Network Meta-Analysis of Randomized Controlled Trials

Dong

Chang

2021

Front. Pharmacol.

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Background: Due to the absence of direct comparisons of different therapeutic drugs in preventing opioid-induced cough (OIC) during the induction of general anesthesia, clinicians often faced difficulties in choosing the optimal drug for these patients. Hence, this network meta-analysis was conducted to solve this problem.Methods: Online databases, including Pubmed, Embase, Web of Science, Cochrane, and Google Scholar, were searched comprehensively to identify eligible randomized controlled trials (RCTs), up to March 15th, 2021. Within a Bayesian framework, network meta-analysis was performed by the “gemtc” version 0.8.2 package of R-3.4.0 software, and a pooled risk ratio (RR) associated with 95% credible interval (CrI) was calculated.Results: A total of 20 RCTs were finally enrolled, and the overall heterogeneity for this study was low to moderate. Traditional pair-wise meta-analysis results indicated that all of the five drugs, namely, lidocaine, ketamine, dezocine, butorphanol, and dexmedetomidine could prevent OIC for four clinical outcomes, compared with the placebo (all p-values < 0.05). Moreover, dezocine had the best effect, compared with that of the other drugs (all p-values < 0.05). Network meta-analysis results suggested that the top three rank probabilities for four clinical outcomes from best to worst were dezocine, butorphanol, and ketamine based on individual/cumulative rank plots and surface under the cumulative ranking curve (SUCRA) probabilities. The node-splitting method indicated the consistency of the direct and indirect evidence.Conclusions: Our results indicated that all of these five drugs could prevent OIC compared with the placebo. Moreover, the top three rank probabilities for four clinical outcomes from best to worst were dezocine, butorphanol, and ketamine. Our results were anticipated to provide references for guiding clinical research, and further high-quality RCTs were required to verify our findings.Systematic Review Registration: [https://www.crd.york.ac.uk/prospero/], identifier [CRD42021243358].

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Comparison of Lidocaine and Atropine on Fentanyl-Induced Cough: A Randomized Controlled Study

Abstract: We determined that premedication with atropine suppressed the incidence and severity of fentanyl-induced cough during induction of general anesthesia. We think that, due to its antimuscarinic effect, atropine is as effective as lidocaine as a premedication.

Cited by 9 publications

References 18 publications

WITHDRAWN: Comparison of a small dose of oxycodone and sufentanil for the prevention of sufentanil-induced cough during general anesthesia induction: a prospective randomized controlled trial

WITHDRAWN: Comparison of a small dose of oxycodone and sufentanil for the prevention of sufentanil-induced cough during general anesthesia induction: a prospective randomized controlled trial

Mechanism and Management of Fentanyl-Induced Cough

Comparison of Five Prophylactically Intravenous Drugs in Preventing Opioid-Induced Cough: A Bayesian Network Meta-Analysis of Randomized Controlled Trials

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