Comparison of lidocaine and lidocaine–epinephrine for the paravertebral brachial plexus block in dogs

Choquette, Amélie; Castillo, J; Moreau, Maxim; Guillot, Martin; Alexander, Kate; Kona‐Boun, Jean‐Jacques; Gauvin, Dominique; Troncy, Éric

doi:10.1016/j.vaa.2016.08.002

Cited by 7 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This, of course, can be explained by a more pronounced anesthetic effect when the anesthetic also has a vasoconstrictor. A study in dogs showed that the addition of epinephrine (precursor of adrenaline) to lidocaine prolonged the duration and increased the intensity of the regional block and at the same time no significant difference was noted in regard to sensory blockade (Choquette et al, 2017 ). Patients with additional adrenaline did feel less pain according to VAS, but we have found no significance between the group.…”

Section: Discussionmentioning

confidence: 99%

The changes in levels of blood cortisol, glucose, and oxygen saturation in type 2 diabetic patients during tooth extraction

Agani

Ahmedi

Abdyli

et al. 2022

Clinical & Exp Dental Res

View full text Add to dashboard Cite

Objectives: The extraction of a tooth exacerbates the stress in diabetic patients leading to diabetic complications so the aim was to evaluate the changes in blood cortisol, glucose, and oxygen saturation in type 2 diabetic patients during tooth extraction to pay special attention during a routine surgical procedure. Materials and Methods:The research included 40 patients with type 2 diabetes with indications of tooth extraction. They were divided into two subgroups by 20 participants and split according to local anesthesia (lidocaine with additional adrenaline or lidocaine only). Cortisol, blood sugar, blood pressure, arterial pulse, and blood oxygen saturation were measured. Patients were also evaluated for their sensitivity to pain through the Visual Analog Scale (VAS).Results: Cortisol and glucose levels scientifically increased throughout the procedure. Meanwhile, systolic, and diastolic blood pressure and saturation showed no difference between the measurements during and after tooth extraction (p = .280; p = .090; p = .590, respectively). Most patients (60.0%) felt no pain during/after the procedure. None of the subjects was feeling more pain than 30 points by VAS. The comparison between groups receiving lidocaine showed no statistical differences when adding adrenaline to lidocaine. Evaluation of pain by VAS showed that more patients felt pain when they were receiving lidocaine without adrenaline.Conclusions: Diabetic patients require a more cautious approach when undergoing teeth extractions despite it being a routine procedure.

show abstract

Section: Discussionmentioning

confidence: 99%

The changes in levels of blood cortisol, glucose, and oxygen saturation in type 2 diabetic patients during tooth extraction

Agani

Ahmedi

Abdyli

et al. 2022

Clinical & Exp Dental Res

View full text Add to dashboard Cite

show abstract

“…Once the needle in position, the electrical stimulation technique (Stimuplex ® Dig RC, Braun Medical Inc., Bethlehem, PA, USA) was combined to ultrasound visualisation in order to validate needle positioning through the characteristic motor responses for each root: shoulder rotation with C6, elbow flexion with C7 and carpus/digits flexion with C8-T1 [7]. Details of the guided loco-regional block and rationale for diluting the tested local anesthetic solutions are subject of a separate publication [17]. …”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics of Lidocaine Hydrochloride Administered with or without Adrenaline for the Paravertebral Brachial Plexus Block in Dogs

et al. 2017

Self Cite

View full text Add to dashboard Cite

Adrenaline is known to prolong the duration of local anesthesia but its effects on the pharmacokinetic processes of local anesthetic drugs are not fully understood. Our objective was to develop a compartmental model for quantification of adrenaline’s impact on the pharmacokinetics of perineurally-injected lidocaine in the dog. Dogs were subjected to paravertebral brachial plexus block using lidocaine alone or adrenalinated lidocaine. Data was collected through a prospective, randomised, blinded crossover protocol performed over three periods. Blood samples were collected during 180 minutes following block execution. Compartmental pharmacokinetic models were developed and their goodness-of-fit were compared. The lowering effects of adrenaline on the absorption of lidocaine were statistically determined with one-sided tests. A one-compartment disposition model with two successive zero-order absorption processes best fitted our experimental data. Adrenaline decreased the peak plasma lidocaine concentration by approximately 60% (P < 0.001), decreased this local anesthetic’s fast and slow zero-order absorption rates respectively by 50% and 90% (P = 0.046, and P < 0.001), which respective durations were prolonged by 90% and 1300% (P < 0.020 and P < 0.001). Lidocaine demonstrated a previously unreported atypical absorption profile following its paravertebral injection in dogs. Adrenaline decreased the absorption rate of lidocaine and prolonged the duration of its absorption.

show abstract

Complications Associated with Locoregional Anesthesia

Fischer,

Martin‐Flores

2024

Small Animal Regional Anesthesia and Analgesia

View full text Add to dashboard Cite

Comparison of lidocaine and lidocaine–epinephrine for the paravertebral brachial plexus block in dogs

Cited by 7 publications

References 26 publications

The changes in levels of blood cortisol, glucose, and oxygen saturation in type 2 diabetic patients during tooth extraction

The changes in levels of blood cortisol, glucose, and oxygen saturation in type 2 diabetic patients during tooth extraction

Pharmacokinetics of Lidocaine Hydrochloride Administered with or without Adrenaline for the Paravertebral Brachial Plexus Block in Dogs

Complications Associated with Locoregional Anesthesia

Contact Info

Product

Resources

About