“…However, the absorption and duration of this agent is slower in comparison with gel preparation. Therefore, the 0.5% tetracaine eye drop must be administered repeatedly with the risk of corneal epithelial damage due to its toxic reactions, including punctate keratopathy, persistent epithelial defect, ring shaped stromal infiltration, corneal edema, Descemet’s membrane filding, endothelial cell loss to neurotrophic ulcer, stromal melting, secondary infectious keratitis, corneal scarring, and corneal perforation (2, 3). …”