Comparison of Lipid Profile in Patients With and Without Acute Myocardial Infarction

Mal, Kheraj; Kumar, Ratan; Ejaz, Mishal; Fatima, Kiran; Shaukat, Faizan

doi:10.7759/cureus.6467

Cited by 6 publications

(6 citation statements)

References 11 publications

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“…Several studies had shown the link between dyslipidaemia and cardiovascular diseases (CVDs). 9,21,22 Stabilising lipid levels in the blood and providing the correct therapy considered an essential key for optimal treatment and a better prognosis for the patients. 23,24 From this point, the urge for understanding and learning guidelines in the healthcare providing system is essential.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of physician’s knowledge in Jordan about the ACC/AHA blood cholesterol guidelines

et al. 2020

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Background Elevated levels of blood lipids are considered a major modifiable risk factor for the development of cardiovascular diseases. The optimal management of dyslipidaemia remains inadequate worldwide. Accordingly, there is an increasing need to evaluate the basis that health care providers are using to control dyslipidaemia. Aim To evaluate the awareness of Jordanian physicians about the American College of Cardiology/American Heart Association (ACC/AHA) guidelines for dyslipidaemia management. Method A written questionnaire was distributed to 250 physicians from different areas of Jordan during 7 months period (from February 2018 until the end of August 2018). The target population is composed of the following categories: juniors, residents, fellows and consultants who were recruited from private, government and military practice settings. The validated developed questionnaire was distributed by trained medical personnel. Results A total of 207 physicians filled and handed back the questionnaire. The response rate was 82.8%. Generally, there was a difference in the level of knowledge between physicians (juniors/ residents/ consultants) while there was no difference between genders or practice settings (private or government). The current study showed that the awareness of physicians in different areas of Jordan regarding the 2013 (ACC/AHA) dyslipidaemia guidelines is suboptimal. Conclusion Results indicated low levels of knowledge of 2013 ACC/AHA guidelines for the management of dyslipidaemia among physicians in Jordan. Hence, multiple interventions are needed to be implemented in order to increase the level of awareness among Jordanian physicians.

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Section: Discussionmentioning

confidence: 99%

Evaluation of physician’s knowledge in Jordan about the ACC/AHA blood cholesterol guidelines

et al. 2020

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“…This study included the samples of 53 MI-positive patients, male and female, and inhibition was checked by a spectrophotometer at 520 nm, which showed 91.73 % inhibition in MI patients. Mal et al compared demographically the lipid profile of two groups in 421 participants, including the patient group (MI patients, n = 212) and the control group (non-MI patients, n = 209) (22). The TC and LDL were remarkably elevated in patients with MI.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Biochemical Parameters with Inhibition of Oxidative Stress in Myocardial Infarction Patients: In Vitro Study

et al. 2023

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Background: Myocardial infarction (MI) is the main cause of illness, mortality, and stress worldwide. Oxidative stress is the major cause of myocardium tissue damage associated with cell necrosis. Objectives: The current study was designed to compare biochemical parameters with in vitro antioxidant activity in MI patients. Methods: This observational cohort study was conducted on 53 MI patients, and the samples were collected on the basis of a non-random sampling technique from April 2022 to November 2022. Lipid profile (i.e., total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and triglycerides (TG)) and cardiac profile (i.e., troponin T, troponin I, creatine kinase MB (CK-MB), and creatine phosphokinase (CPK)) were measured for the confirmation of variation in biochemical parameters. Afterward, the inhibition of oxidative stress was analyzed through the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay on the serum samples of the patients. Results: Of 53 MI patients, 33 and 20 cases were male and female, respectively. Moreover, the correlation of the DPPH assay with TC, troponin T, and troponin I was determined by Pearson correlation. The correlation coefficients range from -1 to 1, indicating the strength and direction of the linear relationship between the markers. The concentrations of lipid profile (i.e., TC, TG, LDL, and VLDL) or cardiac profile (i.e., CK-MB, CPK, troponin T, and troponin I) were significantly elevated in all MI patients. However, the HDL level (P = 0.001) was decreased. Conclusions: According to obtained results, reactive oxygen species (ROS) might be the causative agent of MI. Therefore, if an antioxidant medication is used as administrative content, it would be helpful for the treatment of MI and a lead mark for pharmaceutical companies in drug designing for MI patients.

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“…Our results may be explained with the modification of the lipid profile that happens early after an acute coronary syndrome (ACS). Almost all researchers agree that after an AMI a phasic fluctuation of the lipid profile may be observed, with a trend that includes reduced total cholesterol, LDL and HDL and increased triglycerides [ 53 ]. These changes generally become manifest within 24–48 h after an acute coronary syndrome, reach a maximum level within approximately 4–7 days and are present for a few months.…”

Section: Discussionmentioning

confidence: 99%

Two RECK Splice Variants (Long and Short) Are Differentially Expressed in Patients with Stable and Unstable Coronary Artery Disease: A Pilot Study

Vancheri

Morini

Prandi³

et al. 2021

Genes

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Primary prevention is crucial for coronary heart disease (CAD) and the identification of new reliable biomarkers might help risk stratification or predict adverse coronary events. Alternative splicing (AS) is a less investigated genetic factors implicated in CAD etiology. We performed an RNA-seq study on PBMCs from CAD patients and control subjects (CTR) and observed 113 differentially regulated AS events (24 up and 89 downregulated) in 86 genes. The RECK (Reversion-inducing-cysteine-rich protein with Kazal motifs) gene was further analyzed in a larger case study (24 CTR subjects, 72 CAD and 32 AMI patients) for its Splicing-Index FC (FC = −2.64; p = 0.0217), the AS event involving an exon (exon 18), and its role in vascular inflammation and remodeling. We observed a significant downregulation of Long RECK splice variant (containing exon 18) in PBMCs of AMI compared to CTR subjects (FC = −3.3; p < 0.005). Interestingly, the Short RECK splice variant (lacking exon 18) was under-expressed in AMI compared to both CTR (FC = −4.5; p < 0.0001) and CAD patients (FC = −4.2; p < 0.0001). A ROC curve, constructed combining Long and Short RECK expression data, shows an AUC = 0.81 (p < 0.001) to distinguish AMI from stable CAD patients. A significant negative correlation between Long RECK and triglycerides in CTR group and a positive correlation in the AMI group was found. The combined evaluation of Long and Short RECK expression levels is a potential genomic biomarker for the discrimination of AMI from CAD patients. Our results underline the relevance of deeper studies on the expression of these two splice variants to elucidate their functional role in CAD development and progression.

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Comparison of Lipid Profile in Patients With and Without Acute Myocardial Infarction

Cited by 6 publications

References 11 publications

Evaluation of physician’s knowledge in Jordan about the ACC/AHA blood cholesterol guidelines

Evaluation of physician’s knowledge in Jordan about the ACC/AHA blood cholesterol guidelines

Comparison of Biochemical Parameters with Inhibition of Oxidative Stress in Myocardial Infarction Patients: In Vitro Study

Two RECK Splice Variants (Long and Short) Are Differentially Expressed in Patients with Stable and Unstable Coronary Artery Disease: A Pilot Study

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