Comparison of Lipid Profiles in Normal Pregnancy and in PreEclampsia: A Case Control Study

Das, Swapan K.; Char, Debasish; Sarkar, Sanjay; Das, P. C.; Saha, Tushar Kanti; Biswas, Sucheta

doi:10.9790/0853-1145355

Cited by 7 publications

(7 citation statements)

References 12 publications

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“…They also found significant elevation of TG and VLDL in third trimester as compared to NT patient. In the study done by Das and his team, 23 however, only rise of TG was found in the preeclampsia patients (PET group) as compared to normal patient (NT group) (p = <0.002) and no difference in other parameters of lipid profile were observed. The rise in only the TG value have found in many other studies as well.…”

Section: Nmcjmentioning

confidence: 80%

“…10 There were many studies done to see the level of dyslipidemia in PET patients but the findings were inconsistent. [11][12][13][14][15][16][17][18][19] A large systematic meta-analysis was done to see the association of dyslipidemia in PET patients with the inclusion of 74 studies (from 1950 -July 2013) in which they found that TC, TG LDL and VLDL was significantly increased and HDL was decreased. 11 Similar findings were observed in studies done by Anuradha and her team 12 and Despande et al 13 whereas in some studies significant rise of only TG was found as compared to NT group.…”

Section: Introductionmentioning

confidence: 99%

“…11 Similar findings were observed in studies done by Anuradha and her team 12 and Despande et al 13 whereas in some studies significant rise of only TG was found as compared to NT group. [14][15][16] Many studies observed that PET preceded by dyslipidaemia in first and second trimester particularly hypertriglyceridemia and elevated lipoprotein which indicates that they may be etiologic and pathophysiologic mechanism responsible for PET. [17][18][19] In paper describes the association of dyslipidemia in PET group as compared to NT group of pregnancy at a tertiary care center in Nepal.…”

Section: Introductionmentioning

confidence: 99%

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Lipid Profile in Preeclampsia Patients as Compared to Normal Patient

2020

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The main objective of the study was to see the association of dyslipidemia in preeclampsia (PET) as compare to normotensive (NT) patients. It was a descriptive study done in Nepal Medical College Teaching Hospital Department of Obstetrics and Gynecology from April 2019 from April 2020. A total of 75 PET (test group) and 75 NT (control group) in their third trimester were included. Their fasting lipid profile was studied. It was found that triglyceride (TG) and very low density lipoprotein (VLDL) was significantly high among PET group as compared to that of NT patients. The mean TG of PET group was 266.11± 98.61 and the NT group was 187±58.56 (p=0.00) and the mean VLDL of PET group was 46.00±15.31 and NT group was 37.88±12.85 (p=0.001). On the other hand, the total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) were not significantly different in both the groups. It was also found that with the severity of the disease (Preeclampsia), the level of TG and VLDL increased significantly. Therefore, among the investigation done for PET, we should include lipid profile, especially the TG and VLDL. Furthermore, TG and VLDL should be measured serially (at least once a week) so as to predict the progress of PET and manage the patient accordingly.

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Section: Nmcjmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lipid Profile in Preeclampsia Patients as Compared to Normal Patient

2020

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“…The increased levels of triglyceride are related with hyper coagulability [24]. Altered lipid synthesis leading to decreased in Prostaglandin I2 (PGI2): Thromboxane A2 (TXA2) ratio is also supposed to be an important way of pathogenesis in pre-eclampsia [25].…”

Section: Original Research Articlementioning

confidence: 99%

Pre–eclampsia and dyslipidaemia a case control study: an experience of tertiary healthcare centre in central India

Yadav

Jain

Toppo

et al. 2018

Trop J Pathol Microbiol

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Introduction: Pre-eclampsia is a multisystem disorder of pregnancy which is characterized by hypertension with proteinuria after 20 weeks of gestation in previously normotensive and non proteinuric pregnant women. Pre-eclampsia associated with intrauterine growth retardation, preterm birth, maternal and perinatal death. Dyslipidaemia has been shown to play a significant role in the pathogenesis of the disease and often precede linical manifestations. Objective: To compare the serum lipid profile in pre-eclampsia case and normal pregnant women and to assess its role in pre-eclampsia. Material and Method: 158 patients of which 79 pre-eclampsia (cases) and 79 (controls) were selected randomly and were matched with their gestational age in patient who Attending ANC clinic at Department of obstetrics and genecology in March 2016 to August 2017. Lipid profile was estimated by the Randoximola is a compact fully automated clinical chemistry analyser. Result: We observed that pre-eclampsia is more common in young age pregnant women with low socioeconomic status with strenuous activities. The mean age was 24.51±3.707 years. The mean cholesterol, triglyceride, LDL,VLDL, value is analysed with control group showing significantly increase (p<0.0001) and HDL value significantly decreasedin pre-eclampsia patient in comparison to the normal control group (p<0.0001). Conclusion: Young age, nulliparity, low socioeconomic status specially labour occupation, dyslipidaemic pregnant women were found to be more prone to develop pre-eclampsia. Proper history tacking, examination and estimation of lipid profile may be helpful forearly diagnosis and management of pre-eclampsia in order to prevent fetal and maternal complications especially in nulliparous women.

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“…Significantly elevated plasma concentration of triglycerides (TG), phospholipids and total lipids and decreased high density lipoprotein -cholesterol (HDL-C) concentrations were found in women with eclampsia in comparison to normal pregnancy. 5,6,7,8…”

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confidence: 99%

Study of Lipid Profile in Eclampsia

Patel¹,

Pradhan²,

Jena³

et al. 2017

jemds

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BACKGROUND Eclampsia occurs in about 1.56% of pregnancies in our country and is an important cause of foetal and maternal morbidity and mortality. Altered lipid synthesis leading to decrease in PGI2:TxA2 ratio is also supposed to be an important way of pathogenesis in pregnancy-induced hypertension leading to eclampsia. The aim of this study was to determine and compare the serum lipid levels among women with eclampsia and women having normal pregnancy without hypertension. MATERIALS AND METHODS This is a descriptive comparative study where lipid profile of 100 normal pregnant women was compared with 100 eclamptic women. RESULTS Serum cholesterol, LDL & VLDL showed a steady rise with an increase in systolic and diastolic blood pressure. The range of serum HDL showed a steady fall with an increase in systolic & diastolic blood pressure. CONCLUSION There was an increase in the level of serum cholesterol, serum triglycerides, HDL, LDL and VLDL in the eclamptic subjects but not in the control group of normal pregnant women, thus eclamptic women had deranged lipid profile due to abnormal lipid metabolism.

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Comparison of Lipid Profiles in Normal Pregnancy and in PreEclampsia: A Case Control Study

Cited by 7 publications

References 12 publications

Lipid Profile in Preeclampsia Patients as Compared to Normal Patient

Lipid Profile in Preeclampsia Patients as Compared to Normal Patient

Pre–eclampsia and dyslipidaemia a case control study: an experience of tertiary healthcare centre in central India

Study of Lipid Profile in Eclampsia

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