Comparison of Liver Scintigraphy and the Liver-Spleen Contrast in Gd-EOB-DTPA-Enhanced MRI on Liver Function Tests

Mori, Hiroshige; Machimura, Hanaka; Iwaya, Amika; Baba, Masaru; Furuya, Ken

doi:10.21203/rs.3.rs-879858/v1

Cited by 2 publications

(5 citation statements)

References 16 publications

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“…Therefore, a 15-20-minute HBP may be suitable for evaluating the hepatic functional reserve. However, a recent investigation demonstrated the liver-spleen contrast on a 60-minute delay HBP has a strong positive correlation with the receptor index (LHL15) calculated from 99m Tc-GSA liver scintigraphy (53). Therefore, a much longer delayed acquisition time should be recommended for hepatic functional reserve evaluation than that for hepatic lesion detection.…”

Section: The Delay Time Of Hbp Acquisition For the Evaluation Of The ...mentioning

confidence: 99%

Optimization of hepatobiliary phase imaging in gadoxetic acid-enhanced magnetic resonance imaging: a narrative review

Wang¹,

Yuan²,

Wu³

et al. 2023

Quant Imaging Med Surg

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Background and Objective: Gadolinium ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) is widely used in clinical practice. Its unique hepatobiliary phase (HBP) has been used to improve the detection and identification of hepatic lesions and has also been used to evaluate hepatic function and fibrosis. At the early stage of its clinical practice, the HBP was typically collected empirically with a delay of 20 minutes after intravenous administration to image the liver with sufficient enhancement for diagnosis. However, numerous methods and consensus statements for optimizing HBP acquisition have been proposed. This review details the methods and consensus statements on optimizing HBP collection.Methods: The electronic literature search was performed using the databases PubMed, MEDLINE, Cochrane, and Embase without limit on publication period to identify published reports on optimizing HBP imaging in Gd-EOB-DTPA-enhanced MRI. Articles with low relevance to the topics were excluded.Key Content and Findings: Recently, an increasing number of investigations suggest that collecting HBP after 20 min is too drawn-out for patients with normal liver function but is too short for patients with cirrhosis. Previous studies demonstrated that liver enhancement is closely related to liver function in Gd-EOB-DTPA-enhanced MRI. Therefore several reports have proposed various HBP delay times at different liver function levels. These delay times could be evaluated by laboratory indicators, such as prothrombin (PT) activity, total bilirubin, direct bilirubin, and the model for end-stage liver disease. Other investigations have found that the initial visualization time of the intrahepatic bile duct (IHD) in Gd-EOB-DTPA-enhanced MRI to also be related to liver enhancement and function. Therefore, initial visualization of the IHD is considered necessary for adequate HBP and has been employed in HBP acquisition in recent reports. Conclusions:Optimizing HBP acquisition according to individual hepatic function is a good strategy and was followed in most of the investigations included in our review. Obtaining adequate HBP in the shortest possible time is the target condition in Gd-EOB-DTPA-enhanced MRI. However, a more concise and efficient HBP acquisition strategy is still expected to be developed in the future.

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Section: The Delay Time Of Hbp Acquisition For the Evaluation Of The ...mentioning

confidence: 99%

Optimization of hepatobiliary phase imaging in gadoxetic acid-enhanced magnetic resonance imaging: a narrative review

Wang¹,

Yuan²,

Wu³

et al. 2023

Quant Imaging Med Surg

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“…In the SENSE-PAC with CLEAR, these ROIs are not aligned (Figure 1D). Contrasts were calculated using the following Michelson contrast formulas (13,22):…”

Section: Image Analysismentioning

confidence: 99%

“…Moderate correlations have also observed between the LSC and other liver function indexes, such as ALBI score, Child-Push class, and indocyanine green retention rate at 15 min (6,13,15). The LSC levels are also associated with severity of chronic liver diseases (13).…”

Section: Introductionmentioning

confidence: 98%

“…ROIs may be set at an arbitrary placement and adequate size (2,7). Moreover, LSC can be used to separate normal cases from the Grade 1 group of the albumin-bilirubin (ALBI) Grades (13). Therefore, LSC is the simplest and most common technique among these four methods (2).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, Gd-EOB-DTPA-enhanced MRI can evaluate the future remnant liver functional reserve after hepatectomy by adding the liver volume to the LSC because the volume data can be obtained (15). Moderate correlations have also observed between the LSC and other liver function indexes, such as ALBI score, Child-Push class, and indocyanine green retention rate at 15 min (6,13,15). The LSC levels are also associated with severity of chronic liver diseases (13).…”

Section: Introductionmentioning

confidence: 99%

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Liver-spleen contrast standardization of gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced magnetic resonance imaging based on cross-calibration

Mori¹,

Akimoto²

2022

Quant Imaging Med Surg

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Background: Liver-spleen contrast in the hepatobiliary phase highly depends on the devices used for liver function tests. This study aimed to develop and validate a method to convert liver-spleen contrast data acquired with another device to reference liver-spleen contrast data, using the regression line of phantom contrasts (i.e., cross-calibration).Methods: As cohort studies, two-dimensional gradient echo images of T1-weighted fat-suppression in the hepatobiliary phase were retrospectively obtained and analyzed for a total of 126 patients who underwent gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced magnetic resonance imaging using four different magnetic resonance imaging scanner-coil combinations. The liver-spleen contrast measured from these images was converted into reference liver-spleen contrast using cross-calibration with purified water and gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid phantoms of 0.06, 0.14, 0.27, 0.63, 1.37, and 2.82 mM/L. At this point, the error of the regression lines with phantom contrasts was assessed and corrected. Lastly, the liver-spleen and converted liver-spleen contrasts, which are the values before and after cross-calibration respectively, were compared with reference liver-spleen contrast in three cases using different coils and magnetic resonance imaging scanners from a reference device.Results: Regarding the regression lines with phantom contrasts, the coefficient of determination was 0.99.Although regression lines with phantom contrasts tended to be 0.0105 lower in logarithmic contrasts than those with liver-spleen contrast, no significant difference was observed between the two lines (P=0.0612) by analysis of covariance. In the case of different coils, there was a significant difference between liver-spleen and reference liver-spleen contrasts (P<0.00001), but there was no significant difference between converted liver-spleen and reference liver-spleen contrasts (P=0.492). Moreover, the regression equation between converted liver-spleen and reference liver-spleen contrasts corresponded with an identity line. Likewise, in the two cases of different magnetic resonance imaging scanners, there was a significant difference between liver-spleen and reference liver-spleen contrast (both P<0.00001), but there was no significant difference between converted liver-spleen and reference liver-spleen contrast (P=0.923 and P=0.541).Conclusions: Cross-calibration using the precision and valid regression lines with phantom contrasts had high accuracy and utility.^ ORCDI: 0000-0003-1378-5970.

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Comparison of Liver Scintigraphy and the Liver-Spleen Contrast in Gd-EOB-DTPA-Enhanced MRI on Liver Function Tests

Cited by 2 publications

References 16 publications

Optimization of hepatobiliary phase imaging in gadoxetic acid-enhanced magnetic resonance imaging: a narrative review

Optimization of hepatobiliary phase imaging in gadoxetic acid-enhanced magnetic resonance imaging: a narrative review

Liver-spleen contrast standardization of gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid-enhanced magnetic resonance imaging based on cross-calibration

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