Aero‐disk is a key component of aero‐engine. Due to its complex working conditions, aero‐disk is prone to structural failures. Therefore, it is essential to analyze the reliability and importance input variables of aero‐disk. In this paper, a framework of aero‐disk reliability analysis and global sensitivity analysis (GSA) was established. First, the hazardous regions of aero‐disk were determined by finite element analysis, and the limit state function of aero‐disk was defined by the life interference model. Then D‐Vine model was utilized to establish the correlation model for aero‐disk hazardous regions to evaluate the reliability of aero‐disk. In addition, two GSA methods based on Copula and space partition were proposed to identify important input random variables considering underlying correlation, and the accuracy of the proposed method was verified by two examples. Finally, the proposed method was applied to the GSA of aero‐disk. The results show that the established framework fills in the gap of uncertainty analysis of aero‐disk, which can be extended to other engineering fields. The proposed GSA methods have both high efficiency and accuracy and can realize multi‐dimensional GSA when the correlation of input variables is considered.