Comparison of local metronidazole and a local antiseptic in the treatment of bacterial vaginosis

Mikić, Aleksandra Novakov; D, Budakov

doi:10.1007/s00404-009-1241-7

Cited by 25 publications

(13 citation statements)

References 17 publications

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“…The topical application of systemic antibiotics for skin, mucous membrane and wound infections is obsolete with only one exception: The same antibiotic is given orally or parenterally in case of metastatic infection [132], [133]. Antiseptics are more effective than antibiotics in vitro [134], [135], equally effective in vivo [136], [137] and, administered topically, as compatible as antibiotic eye drops [138]. In contrast to antiseptics with a microbiostatic specific mode of action (chlorhexidine, triclosane, QAC, silver ions [cf.…”

Section: Principal Treatment Optionsmentioning

confidence: 99%

Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?

Exner

Bhattacharya

Christiansen

et al. 2017

GMS Hygiene and Infection Control; 12:Doc05

191

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Section: Principal Treatment Optionsmentioning

confidence: 99%

Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?

Exner

Bhattacharya

Christiansen

et al. 2017

GMS Hygiene and Infection Control; 12:Doc05

191

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“…A recent study evaluated the efficacy of octenidine hydrochloride/ phenoxyethanol, a local antiseptic spray, applied for 7 or 14 days compared with 7 days of metronidazole vaginal tablets for BV therapy 72. The local antiseptic spray was as effective as the standard therapy with cure rates of 58% and 71% at 7 days and 14 days, respectively, compared with 61% at 7 days with metronidazole.…”

Section: Emerging Therapiesmentioning

confidence: 99%

Antibacterial treatment of bacterial vaginosis: current and emerging therapies

Ménard¹

2011

IJWH

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Bacterial vaginosis is a common cause of malodorous vaginal discharge. It is also associated with sexually transmitted infections and adverse pregnancy outcomes. The magnitude of the gynecological and obstetrical consequences has stimulated therapeutic research and led to the testing of several therapies. The objective of this work is to present the currently available therapeutic strategies for the treatment of bacterial vaginosis and associated recommendations, and discuss the emerging therapies.

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“…In a large Serbian RCT, the efficacy of an octenidine hydrochloride/phenoxyethanol spray as compared to standard treatment with 500 mg metronidazole vaginal tablets for 7 days was assessed among 450 patients enrolled in an outpatient gynecology clinic and diagnosed with BV according to Amsel’s criteria [18]. Unfortunately, the authors did not specify how cure was defined.…”

Section: Resultsmentioning

confidence: 99%

“…Unfortunately, the authors did not specify how cure was defined. In particular, the authors state that study participants were “ examined gynecologically” and that “control smears were taken for further bacteriologic analysis” [18]. We therefore repeatedly tried to contact the authors with a request for more detailed information; however we did not get any response.…”

Section: Resultsmentioning

confidence: 99%

Antiseptics and disinfectants for the treatment of bacterial vaginosis: A systematic review

et al. 2012

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Background The study objective was to assess the available data on efficacy and tolerability of antiseptics and disinfectants in treating bacterial vaginosis (BV). Methods A systematic search was conducted by consulting PubMed (1966-2010), CINAHL (1982-2010), IPA (1970-2010), and the Cochrane CENTRAL databases. Clinical trials were searched for by the generic names of all antiseptics and disinfectants listed in the Anatomical Therapeutic Chemical (ATC) Classification System under the code D08A. Clinical trials were considered eligible if the efficacy of antiseptics and disinfectants in the treatment of BV was assessed in comparison to placebo or standard antibiotic treatment with metronidazole or clindamycin and if diagnosis of BV relied on standard criteria such as Amsel’s and Nugent’s criteria. Results A total of 262 articles were found, of which 15 reports on clinical trials were assessed. Of these, four randomised controlled trials (RCTs) were withheld from analysis. Reasons for exclusion were primarily the lack of standard criteria to diagnose BV or to assess cure, and control treatment not involving placebo or standard antibiotic treatment. Risk of bias for the included studies was assessed with the Cochrane Collaboration’s tool for assessing risk of bias. Three studies showed non-inferiority of chlorhexidine and polyhexamethylene biguanide compared to metronidazole or clindamycin. One RCT found that a single vaginal douche with hydrogen peroxide was slightly, though significantly less effective than a single oral dose of metronidazole. Conclusion The use of antiseptics and disinfectants for the treatment of BV has been poorly studied and most studies are somehow methodologically flawed. There is insufficient evidence at present to advocate the use of these agents, although some studies suggest that some antiseptics may have equal efficacy compared to clindamycin or metronidazole. Further study is warranted with special regard to the long-term efficacy and safety of antiseptics and disinfectants for vaginal use.

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Comparison of local metronidazole and a local antiseptic in the treatment of bacterial vaginosis

Abstract: Octenidine hydrochloride/phenoxyethanol spray was as effective as the standard therapy with metronidazole. Patients stated that OHP was more comfortable, easier to apply, and side effects were lesser.

Cited by 25 publications

References 17 publications

Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?

Antibiotic resistance: What is so special about multidrug-resistant Gram-negative bacteria?

Antibacterial treatment of bacterial vaginosis: current and emerging therapies

Antiseptics and disinfectants for the treatment of bacterial vaginosis: A systematic review

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