Comparison of long-acting testosterone undecanoate formulation versus testosterone enanthate on sexual function and mood in hypogonadal men

Abstract

Objective: To compare the effects of two treatment modalities of testosterone on sexual functioning and mood. Design: Forty men were randomized to receive either parenteral testosterone enanthate (TE) or longacting parenteral testosterone undecanoate (TU) over a period of 30 weeks. Thereafter, 20 men who had received TU and 16 men who had received TE continued with TU and completed another 65 weeks to study longer-term effects of TU. Methods: The following variables of sexual functioning were studied: sexual thoughts and fantasy, sexual interest and desire, satisfaction with sex life, number of erections and ejaculations per week, and number of spontaneous morning erections per week. Also variables related to mood were analyzed. Results: Improvements in these variables were significant and were of a similar magnitude in the group treated with TU and TE for 30 weeks. Improvements were maintained at the same levels over a period of another 65 weeks when all men received TU. Effects on mood were recorded for 30 weeks, but were more difficult to establish in the study population. There were significant differences in baseline values between the two groups and scores showed wide S.D. Conclusions: Both TE and TU were effective in improving sexual functions in hypogonadal men. An advantage of TU over TE is its lower frequency of administration and its better tolerability and safety profile.

Increased frequency of anxiety, depression, quality of life and sexual life in young hypogonadotropic hypogonadal males and impacts of testosterone replacement therapy on these conditions

“…1). tribution [3,4,23]. To our knowledge, there aren't any studies observing the effect of testosterone treatment on ASEX scores in young patients with hypogonadotropic hypogonadism.…”

Factors influencing time course of pain after depot oil intramuscular injection of testosterone undecanoate

“…For example, T pellets implanted at intervals of 6 months have a very high elective continuation rate relative to a cost-minimized choice of alternative T products [6]. More recently, T undecanoate (TU) was developed as an IM injectable depot using an oil vehicle with a 12-week inter-injection interval that greatly 228 npg exceeds older T ester products that typically required a 2-week inter-injection interval [7]. However, owing to limited solubility, TU is marketed in a relatively large (4 mL) castor oil vehicle.…”

Pathophysiology, evaluation and treatment of erectile dysfunction: review article

“…A utilização de reposição hormonal oral se dá principalmente pelo undecanoato de testosterona, com doses de 160 mg/dia, embora não haja relatos de que sua administração melhore a função sexual do paciente 95 . O undecanoato de testosterona também foi administrado via intramuscular tendo melhora parcial em alguns estudos e nenhuma melhora em outros [96][97][98][99] . A administração de dehidroepiandrosterona (DHEA) 50 mg, 2 vezes ao dia, pode ser feita, contudo não há estudos que documentem sua eficácia.…”