Comparison of Long Term Lipogenic Effects of Two Different Medium-Chain Triglycerides (TRI C₈: 0 and TRI C₁₂: 0) in the Growing Rat

Abstract

During the growth (35 g-340 g), and as compared to results obtained with a lipid-free diet or a diet containing long-chain fatty acids, high levels of Tri C8 : O or Tri C12 : O did not change the quantitative aspects of proteinogenesis and lipogenesis balances. The incorporation of Tri C8 : O into the diet did not change the fatty acid composition of body lipid stores while the incorporation of Tri C12 : O induced a lipogenesis characterized by the disappearance of about 50% of the n-9 and n-7 unsaturated fatty acids, the emergence of an equivalent amount of saturated fatty acids in C12 and C14, and the decrease of hexadecanoic or palmitic acid concentration. Titers of saturated fatty acids with a melting point higher than 40 degrees C increased from 34% to 64%. Results suggested an efficient inhibition of fatty acid biosynthesis de novo by C12 : O, associated with an impossibility for microsomal enzymes to assume the elongation of a sufficient amount of C12 : O to maintain C16 : O concentration and to furnish an important amount of substrate (C18 : O) to delta-9-stearoyl coenzyme A desaturase for oleic acid synthesis. Introducing dodecanoic acid into the diet of growing animals appears to be the most efficient method for increasing the degree of saturation of body lipids without changing the concentrations of long-chain saturated fatty acids.

Effects of Maternal Dodecanoic or Laurie Acid (C12:0) Feeding on Milk Fatty Acid Secretion and Lipogenesis in the Suckling Rat

“…Exogenous fatty acids represent ed a higher percentage of total fatty acids in female rats after parturition than in male rats with a corresponding body weight. Higher con centrations recorded for linoleic acid in group A, and especially for lauric acid in group B, corresponded to values generally ob served in older male rats weighing more than 300 g (7). This intensive esterification of exoge nous fatty acid in the pregnant female rat expressed the high level of lipogenesis during gestation (14) As reported in table 11 milk triglyceride fatty to C 14:0), octanoic or caprylic acid (C8:0) and acid compositions were markedly modified by decanoic or capric acid (C l0:0) concentrations maternal nutritional status.…”

“…In earlier reports (7,9) we studied the long-term effects of lauric acid (C l2:0) feeding on the quantitative and/or qualitative aspects of body lipogenesis in weaned growing male rat and pig. MCFA biosynthesis in the active mam mary gland provides a unique opportunity for studying interactions between dietary MCFA and de novo biosynthesis of these molecules.…”

“…Nevertheless, adipose tissue possesses the enzymes necessary to esterify these types of molecules since exogenous fatty acids with 10, 11, 12 or 14 carbon atoms may directly participate in triglyceride biosyn thesis (3,5,18,23). In some nutritional condi tions, dodecanoic or lauric acid (C l2:0) and tetradecanoic or myristic acid (C14:0) may represent more than 30% of total fatty acid triglycerides in the body (7).…”

Influence du remplacement d'une partie du suif d'un aliment d'allaitement par de la tricaproïne ou de la tricapryline en association à de l'huile de coprah sur la croissance du jeune veau préruminant

“…Ces propriétés leur confèrent une excellente digestibilité (N IESAR , 1964 ;T OULLEC & M ATHIEU , 1969 ;V EEN , 1970). De plus, la fixation de protéines corporelles (V EEN , 1970) (A UROUSSEAU et al, 1978 ;D EMARNE et al, 1978 (table 3). The increase in energy efficiency was even larger : -!-30 p. 100 after 3 weeks.…”

Relations entre l'ingestion d'acides gras à chaîne moyenne par la ratte et la lipogénèse du jeune raton avant le sevrage

“…This would indicate that the growth of the lipid compartment was unchanged. The (Demarne et al, 1977b(Demarne et al, , 1978a (Demarne, 1978, …”