Comparison of Long-Term Therapeutic Effect of an ACE Inhibitor, Temocapril, with That of a Diuretic on Microalbuminuria in Non-Diabetic Essential Hypertension.

Shionoiri, Hiroshi; Kosaka, T.; Kita, Eiko; Takizawa, Toshikazu; Takasaki, Izumi

doi:10.1291/hypres.23.593

Cited by 6 publications

(3 citation statements)

References 43 publications

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“…Both antihypertensive treatments in the present study reduced the levels of proteinuria, in agreement with previous studies (20,21). The mechanism of the effects on reducing proteinuria of antihypertensives (ACE inhibitors, CCBs, and α-blocker) (6,22) were explained mainly by reducing blood pressure, but both ACE inhibitors and CCBs are reported that they have the effects which are not due to lowering the blood pressure (2,3).…”

Section: Discussionsupporting

confidence: 92%

The Effects of Antihypertensive Agents on the Survival Rate of Polycystic Kideney Disease in Han: SPRD Rats.

et al. 2002

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Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disorder in humans. Hypertension is one of the major complications, and its control might affect the renal survival and disease mortality. Suitable antihypertensive agents have been discussed based on clinical and animal studies, but no definitive conclusion has been reached. Generally, therefore, all antihypertensives are indiscriminately treated as if providing the same level of blood pressure control. In this study, the blood pressure control of two antihypertensives was investigated using a rat model of ADPKD in humans. Twenty-four male Hannover-Sprague Dawley (Han:SPRD) rats were divided into three groups: a group receiving amlodipine (6 mg/day), a group receiving benazepril (6 mg/day) and an untreated control group. Blood pressure, body weight, and urinary protein excretion were regularly measured up to week 52. Amlodipine and benazepril significantly decreased blood pressure and urinary protein excretion to the same degree. Moreover, a remarkably prolonged survival rate was observed in both groups (at week 52, the survival rate was 25% in controls, 50% in the amlodipine group, and 50% in the benazepril group). Examination at autopsy revealed that enlarged cysts were prevalent in the renal tissue of both experimental all three groups, suggesting that the cystic disease had reached the end-stage in all the animals. In conclusion, both amlodipine and benazepril significantly improved blood pressure control, urinary protein excretion, and survival rate, possibly due to their enhancement of renal survival.

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Section: Discussionsupporting

confidence: 92%

The Effects of Antihypertensive Agents on the Survival Rate of Polycystic Kideney Disease in Han: SPRD Rats.

et al. 2002

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“…Hypertension prevalent in the Japanese population is a significant predictor of renal disease (25), and some antihypertensive medications are reported to exert favorable effects on renal function (26,27). In addition to medical therapies, cardiologists can play an important role in renal artery revascularization treatment (28) because CAD is often associated with RAS, the skills necessary to perform coronary intervention are transferable to the peripheral vasculature (29), and the revascularization of renal arteries may improve hypertension and reduce volume overload.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Predictors of Renal Artery Stenosis in Patients Undergoing Cardiac Catheterization.

et al. 2002

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Renal artery stenosis (RAS) is recognized as a major co-morbid condition for patients with cardiovascular disease. Although the prevalence of RAS in Western countries has been reported as 13.5-18% in patients with suspected coronary artery disease (CAD) undergoing coronary angiography, there is little information available about the prevalence of RAS in Asian populations, which are less susceptible to atherosclerosis. To evaluate the prevalence of RAS in Japanese patients suspected of cardiovascular disease and the relationships among RAS and vascular risk factors, especially hypertension, renal artery angiography was performed in a total of 289 consecutive patients receiving diagnostic cardiac catheterization. RAS with a stenosis diameter greater than 50% was considered significant. The prevalence of RAS was 21/289 (7%) including 18 (6%) cases of unilateral stenosis and 3 (1%) of bilateral stenosis. RAS accompanied 14/220 (6%) cases of CAD, 4/34 (12%) cases of valvular heart disease and 1/14 (7%) cases of cardiomyopathy. In the subgroups of CAD, the prevalence of RAS was 5%, 10%, 9%, and 19% in cases of 0, 1, 2 and 3-vessel disease, respectively. Hypertension was more frequent among patients with than among those without RAS (86% vs. 45%, p=0.0003). The prevalence of RAS was 13% in hypertensives and 2% in normotensives (p = 0.004). Thus RAS was frequent in patients with established CAD, and particularly in those with 3-vessel disease. Together, the results showed that hypertension was closely associated with RAS, appearing as both a risk factor and a possible clinical manifestation of the disease. We conclude that more attention should be paid to RAS in Japanese patients with hypertension and cardiovascular disease.

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“…‡ p < 0.01, as compared with values between the groups at the same times. ***Abnormal UAE was considered to be any value higher than 3.34 mg albumin/mmol Cr, which was the normal value (1.03 mg albumin/mmol Cr) + 3SD (2.31 mg albumin/mmol Cr) of UAE(12). S-Cr, serum creatinine; S-UA, serum uric acid; UAE, urinary albumin excretion rate.…”

mentioning

confidence: 99%

Pharmacological and Clinical Studies with Temocapril, an Angiotensin Converting Enzyme Inhibitor that is Excreted in the Bile

Yasunari

Maeda

Nakamura

et al. 2004

Cardiovascular Drug Reviews

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Temocapril is an angiotensin converting enzyme inhibitor (ACEI), a prodrug with a thiazepine ring. Its active form, temocaprilat, is slightly more potent than enalaprilat in inhibiting ACE isolated from rabbit lung. The inhibitory potency of temocaprilat on isolated rat aorta is 3 times that of enalaprilat. Temocapril is excreted in the bile and urine and can be used in patients with renal insufficiency. It reduces blood pressure without causing any significant change in heart rate or cardiac output. Temocapril has been reported to improve endothelial dysfunction in vitro by suppressing increased oxidative stress. In vivo it improves reactive hyperemia in patients with essential hypertension. It has been reported to prevent coronary vascular remodeling in vivo by suppressing local ACE and increased oxidative stress. In humans temocapril has been found to improve insulin resistance partly by increasing adiponectin levels. Cardiac remodeling was improved by temocapril not only in experiment animals but also in humans. It improves renal function and decreases urinary albumin excretion in diabetics as well as in hypertensive patients. Temocapril is currently marketed only in Japan. Considering its beneficial effects and unique pharmacokinetics, temocapril, is likely to be introduced in other countries as well.

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Comparison of Long-Term Therapeutic Effect of an ACE Inhibitor, Temocapril, with That of a Diuretic on Microalbuminuria in Non-Diabetic Essential Hypertension.

Cited by 6 publications

References 43 publications

The Effects of Antihypertensive Agents on the Survival Rate of Polycystic Kideney Disease in Han: SPRD Rats.

The Effects of Antihypertensive Agents on the Survival Rate of Polycystic Kideney Disease in Han: SPRD Rats.

Prevalence and Predictors of Renal Artery Stenosis in Patients Undergoing Cardiac Catheterization.

Pharmacological and Clinical Studies with Temocapril, an Angiotensin Converting Enzyme Inhibitor that is Excreted in the Bile

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