Comparison of low level laser, ultrasonic therapy and association in joint pain in Wistar rats

Coradini, Josinéia Gresele; Mattjie, Thiago Fernando; Bernardino, Giovanni Ribeiro; Peretti, Ana Luiza; Kakihata, Camila Mayumi Martin; Errero, Tatiane Kamada; Escher, Assis Roberto; Bertolini, Gladson Ricardo Flor

doi:10.1016/j.rbre.2013.06.003

Cited by 5 publications

(6 citation statements)

References 25 publications

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“…It is also stressed that with parameters used, similar to the continuous group in our study, thermal ultrasound effects may be discarded, that is, the so called non-thermal effects were responsible for changes in pain threshold in both studies. A different study, with evaluation, injury and ultrasound treatment similar to our study, aiming at evaluating cumulative effects of low-level laser, has observed that isolated application of this resource was better than laser or the association of techniques 15 . In a previous study comparing pulsed and continuous ultrasound, in animals submitted to experimental sciatica model, ultrasound was effective to decrease pain evaluated by clinching time and, similarly to our study, pulsed ultrasound had faster analgesic results 10 .…”

Section: Discussionsupporting

confidence: 66%

Comparison of continuous and pulsed ultrasound therapy in knee hyperalgesia of Wistar rats

Bertolini¹,

Coradini²,

Kunz³

et al. 2014

Revista Dor

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BACKGROUND AND OBJECTIVES:Among electro agents ultrasound is one of the most common, however, there is insufficient evidence of the beneficial effects with the parameters currently used. The aim of this study was to compare the effect of continuous and pulsed ultrasound therapy on experimental hyperalgesia and edema in knees of Wistar rats. METHODS: 18 rats were divided into three groups: CG-control group; GUP -treated with pulsed ultrasound 50%; and GUC -continuous ultrasound. To accomplish the lesion, animals were manually restrained and 100µL of 5% formalin solution were injected into the right tibiofemoral space. For assessment of nociception digital Von Frey filament was used on the medial side of the joint, until clinching. Edema was evaluated with mid-lateral knee caliper. Assessments occurred in the preinjury (EV1), after 15 (EV2), 30 (EV3) and 60 (EV4) minutes of the injury. After EV2, treatment was initiated with ultrasound with 0.4W/cm 2 (SATA), pulsed or continuous. RESULTS:The CG had hypernociception, with no return to baseline. GUP has returned to baseline as from EV3 and for continuous ultrasound in EV4. All three groups showed similar behavior for edema, with onset in EV2, without reduction. CONCLUSION: Therapeutic ultrasound was effective to decrease nociception, and the pulsed form showed early results, however, both forms of application had no effect on the formation and maintenance of acute edema. Keywords: Edema, Pain measurement, Ultrasound therapy. Comparison of continuous and pulsed ultrasound therapy in knee hyperalgesia of Wistar rats* RESUMO JUSTIFICATIVA E OBJETIVOS:Dentre os agentes eletrotér-micos o ultrassom é um dos mais comuns, contudo, há insuficiente evidência dos efeitos benéficos com os parâmetros correntemente utilizados. Assim, o objetivo deste estudo foi comparar o efeito do ultrassom terapêutico contínuo e pulsado sobre hiperalgesia e edema experimentais em joelhos de ratos Wistar. MÉTODOS: Foram utilizados 18 ratos, divididos em três grupos: GC -grupo controle; GUP -tratado com ultrassom pulsado 50%; e, GUC -ultrassom contínuo. Para realizar a lesão, os animais foram contidos manualmente e 100µL de solução de formalina a 5% foram injetados no espaço tíbio-femoral direito. Para avaliação da nocicepção foi utilizado o filamento de Von Frey digital, na face medial da articulação, até a retirada do membro. A avaliação do edema foi realizada com paquimetria médio-lateral ao joelho. As avaliações ocorreram no momento pré-lesão (AV1), após 15 (AV2), 30 (AV3) e 60 (AV4) minutos da lesão. Após AV2, foi iniciado o tratamento com ultrassom com 0,4W/ cm² (SATA), de forma pulsada ou contínua. RESULTADOS: Para GC, houve a presença de hipernocicepção, sem retorno aos valores basais. Para GUP houve retorno aos valores basais a partir de AV3 e para o ultrassom contínuo em AV4. Para o edema, os três grupos apresentaram comportamento semelhante, com formação em AV2, sem redução posterior. CONCLUSÃO: O ultrassom terapêutico mostrou-se eficaz para redução do quadro nociceptivo, sen...

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Section: Discussionsupporting

confidence: 66%

Comparison of continuous and pulsed ultrasound therapy in knee hyperalgesia of Wistar rats

Bertolini¹,

Coradini²,

Kunz³

et al. 2014

Revista Dor

Self Cite

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“…Some studies have reported an improvement in allodynia and hyperalgesia with the use of LLLT. These studies have already demonstrated an improvement in the peripheral nociception of the inferior alveolar nerve (904 nm, 9500 Hz—pulsed, 6 J/cm 2 ) [ 31 ]; in transcranial application (810 nm, 7.2 J/cm 2 ) [ 32 ]; in oxaliplatin-induced acute peripheral neuropathy (7.5 J/cm 2 , GaAlAs, 780 nm) [ 33 ]; in peripheral nerve damage in streptozotocin-induced type 1 diabetes (GaAr, 9500 Hz-pulsed, 6.23 J/cm 2 ) [ 34 ]; and in the case of hyperesthesia induced through the injection of 5% formalin (830 nm, 8 J/cm 2 ) [ 23 ]. No studies have evaluated mechanical allodynia and hyperalgesia after the application of the F1 protein to nerve injuries.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown positive results both in the use of low-level laser therapy and natural latex ( Hevea brasiliensis ) in the recovery of various types of tissues, including peripheral nerves; however, the literature is weak on this subject, presenting contradictory results and reports on the possible effects of combinations of techniques for the treatment of peripheral nerve injuries [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Low-Level Laser Therapy and Purified Natural Latex (Hevea brasiliensis) Protein on Injured Sciatic Nerve in Rodents: Morpho-Functional Analysis

Dias,

Cury,

Dias

et al. 2023

IJMS

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The present study analyzed the effects of low-level laser therapy (LLLT) and the purified natural latex protein (Hevea brasiliensis, F1 protein) on the morpho-function of sciatic nerve crush injuries in rats. One-hundred and eight male Wistar rats were randomly allocated to six groups (n = 18): 1. Control; 2. Exposed (nerve exposed); 3. Injury (injured nerve without treatment); 4. LLLT (injured nerve irradiated with LLLT (15 J/cm2, 780 nm)); 5. F1 (injured nerve treated with F1 protein (0.1%)); and 6. LLLT + F1 (injured nerve treated with LLLT and F1). On the 1st, 7th, 14th, and 56th days after injury, a functional sensory analysis of mechanical allodynia and mechanical hyperalgesia and a motor analysis of grip strength and gait were performed. After 3, 15, and 57 days, the animals were euthanized for morphometric/ultrastructural analyses. The treatments applied revealed improvements in morphometric/ultrastructural parameters compared to the injured group. Sensory analyses suggested that the improvements observed were associated with time progression and not influenced by the treatments. Motor analyses revealed significant improvements in grip strength from the 7th day in the LLLT group and in gait from the 56th day in all treated groups. We concluded that even though the morphological analyses showed improvements with the treatments, they did not influence sensory recovery, and LLLT improved motor recovery.

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“…44 Estudios preclínicos muestran la eficacia del ultrasonido en el tratamiento de inflamación muscular. 45,46 Sin embargo, en estudios clínicos se observa el uso del ultrasonido en combinación con otras terapias para la rehabilitación. [47][48][49] Un reciente meta-análisis reportado en la literatura, evidencia que el ultrasonido falla al disminuir el dolor.…”

Section: Discussionunclassified

Eficacia del ultrasonido terapéutico en el dolor musculoesquelético de espalda baja: una revisión comprensiva

Aguilar-Velázquez

Ávila

López‐Narváez

et al. 2017

Rev Col Med Fis Reh

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RESUMENEl dolor musculoesquelético de espalda baja es quizás el más frecuente. Debido a su impacto físico, emocional y socioeconómico es considerado un problema de salud pública. La Etiología del dolor musculoesquelético de espalda baja se descubre en muy pocas ocasiones, incluso con la tecnología que existe en la actualidad. En la mayor parte de los casos, el dolor de espalda puede ser un síntoma con diversas causas, entre otras: el uso excesivo de actividades agotadoras, posturas incorrectas, degeneración de las vértebras, tensión o espasmos musculares. Los posibles tratamientos que se aplican para disminuir el dolor son los siguientes: ultrasonido terapéutico, ondas de choque y farmacológico. El objetivo de esta revisión es proporcionar la información sobre evidencias acerca de la eficacia del ultrasonido terapéutico en la disminución del dolor musculo esquelético en espalda baja. Palabras clave: ultrasonido terapéutico, dolor, espalda baja. DOI: 10.28957/rcmfr.v27n2a3 ABSTRACTThe muscle-skeletal pain in the lower back area is perhaps the most frequent back-pain. Due to its physical, emotional and socioeconomic impact, it is considered a public health problem. The etiology of the lower back pain is rarely discovered, even using the most advanced technology. In the majority of cases, the lower back pain is a symptom caused by diverse causes, such as excessive tiring-activities, incorrect posture, vertebra degeneration, tension or muscle spasms, among others. The possible treatments to decrease this pain are: therapeutic ultrasound, shock waves and pharmacology treatment. The objective of this review is to determine how effective is the ultrasound therapy to decrease the muscle-skeletal pain of the lower back area.

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Comparison of low level laser, ultrasonic therapy and association in joint pain in Wistar rats

Cited by 5 publications

References 25 publications

Comparison of continuous and pulsed ultrasound therapy in knee hyperalgesia of Wistar rats

Comparison of continuous and pulsed ultrasound therapy in knee hyperalgesia of Wistar rats

Effects of Low-Level Laser Therapy and Purified Natural Latex (Hevea brasiliensis) Protein on Injured Sciatic Nerve in Rodents: Morpho-Functional Analysis

Eficacia del ultrasonido terapéutico en el dolor musculoesquelético de espalda baja: una revisión comprensiva

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