Comparison of M-mode and two-dimensional echocardiographic algorithms used to estimate left ventricular mass: The Coronary Artery Risk Development in Young Adults Study

Paczek, Anna; Gardin, Julius M.; Hardin, J. Michael; Anton‐Culver, Hoda; Kurosaki, Tom; Hsu, Chuanchieh; Bild, Diane E.

doi:10.1016/s0894-7317(05)80002-1

Cited by 16 publications

(12 citation statements)

References 33 publications

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“…The data from the present study show that LV mass calculated by 2D and M-mode yielded comparable values which is in agreement with observations by our group and others [8, 27]. Pacezk, et al showed an adequate correlation for LV mass calculated using M-mode, although with a few technical caveats: 1) Pacezk determined LVM-2D using the truncated ellipsoid formula, which differs slightly from the area-length method used in the present study; and 2) the 2D imaging technology available in our study (“harmonic imaging”) provides improved endocardial definition, which should result in higher accuracy of LV mass assessment compared to “fundamental” imaging as in Pacezk’s study [28].…”

Section: Discussionsupporting

confidence: 94%

“…Although the two imaging modalities are supposed to measure the same anatomic characteristic and have been found to be comparable in some studies [6, 7], others have reported that M-mode overestimates LV mass by approximately 23 g compared to 2D-derived methods [8]. Furthermore, because LV mass is inherently determined by body size, it is common practice to “index” LV mass by some metric representing body size [9].…”

Section: Introductionmentioning

confidence: 99%

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Genetic association of left ventricular mass assessed by M-mode and two-dimensional echocardiography

Barve

Gu²,

Yang³

et al. 2016

Journal of Hypertension

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Background Left ventricular (LV) mass offers prognostic information for assessing cardiovascular disease (CVD) risk. M-mode and two-dimensional (2D) echocardiographically-derived LV mass values have shown high accuracy and reproducibility; however, no studies to date have compared LV mass genetic association findings based on both methods. The aim of this study was to compare associations of single nucleotide polymorphisms (SNPs) from genome-wide association study (GWAS) analyses of LV mass using both methods in the same cohort. Methods and Results LV mass was determined using 2D and M-mode echocardiography in 711 subjects (390 women); SNP genotype data was obtained using the Genome-wide Human SNP Array 6.0. GWAS analyses were performed to obtain panels of SNPs associated with LV mass and LV mass index. The un-indexed LV mass showed excellent agreement (M-mode: 170±47g vs. 2D: 178±56g, Intraclass Correlation Coefficient 0.929 [95% confidence interval: 0.932, 0.909]). The presence of LVH based on M-mode and 2D-derived LV mass index values showed moderate agreement (kappa=0.49). Eleven SNPs showed suggestive association in at least two of four LV mass traits, with one SNP in CDH13 common to all four derived traits. Conclusions M-mode and 2D echocardiography LV mass measurements in the same cohort identified suggestive genetic associations, both shared and unshared, suggesting common LV mass biology underlying the two measures of LV mass. The combined use of M-mode and 2D echo is a novel approach that may increase the yield of genetic association with LV mass.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Genetic association of left ventricular mass assessed by M-mode and two-dimensional echocardiography

Barve

Gu²,

Yang³

et al. 2016

Journal of Hypertension

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“…There is also prognostic value in patients with myocardial infarction or cardiac amyloidosis. 23,24 However, there is little research on the risk factors for new-onset diabetes in the absence of coronary artery disease. In our study, the MPI value was increased in diabetic with a normal ejection fraction.…”

Section: T a B L E 2 Factors Associated With Prediabetesmentioning

confidence: 99%

Left ventricular myocardial performance index in prediabetic patients without coronary artery disease

et al. 2018

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“…Preference for M-mode is based on its technical feasibility and availability at the time when most studies were performed. However, despite adequate correlation with two-dimensional measurements [9], M-mode has been suggested to averagely underestimate LV mass in about 20 g [10]. Theoretically, two-dimensional imaging would be more adequate in samples of patients with cardiovascular disease, where LV shape assumptions play a critical role in LV mass estimation.…”

Section: Left Ventricular Measurementmentioning

confidence: 99%

Echocardiography-based left ventricular mass estimation. How should we define hypertrophy?

Foppa

Duncan

Rohde

2005

Cardiovasc Ultrasound

222

161

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Left ventricular hypertrophy is an important risk factor in cardiovascular disease and echocardiography has been widely used for diagnosis. Although an adequate methodologic standardization exists currently, differences in measurement and interpreting data is present in most of the older clinical studies. Variability in border limits criteria, left ventricular mass formulas, body size indexing and other adjustments affects the comparability among these studies and may influence both the clinical and epidemiologic use of echocardiography in the investigation of the left ventricular structure. We are going to review the most common measures that have been employed in left ventricular hypertrophy evaluation in the light of some recent population based echocardiographic studies, intending to show that echocardiography will remain a relatively inexpensive and accurate tool diagnostic tool.

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Comparison of M-mode and two-dimensional echocardiographic algorithms used to estimate left ventricular mass: The Coronary Artery Risk Development in Young Adults Study

Cited by 16 publications

References 33 publications

Genetic association of left ventricular mass assessed by M-mode and two-dimensional echocardiography

Genetic association of left ventricular mass assessed by M-mode and two-dimensional echocardiography

Left ventricular myocardial performance index in prediabetic patients without coronary artery disease

Echocardiography-based left ventricular mass estimation. How should we define hypertrophy?

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