Comparison of mandibular trabecular structures between normal and diabetic rats: evaluation of spontaneous type 2 diabetes in a rat model

Onoyama, Kazuo; Kawamata, Ryota; Kozai, Yusuke; Sakurai, Takashi; Kashima, Isamu

doi:10.1007/s11282-011-0065-x

Cited by 9 publications

(6 citation statements)

References 38 publications

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“…Similar results were achieved by Onoyama et al (33), who conducted a study addressing the effect of T2DM on mandibular bone in GK diabetic rats in comparison to nondiabetic Wistar rats (control group). GK diabetic rats showed a reduced medullary BMD in the mandibular molar area, regional morphological changes, and a reduction in bone hardness.…”

Section: Discussionsupporting

confidence: 85%

Relation of Cone Beam Computed Tomography Assessment of Mandibular Bone Density to Dual Energy X-Ray Absorptiometry in Type 2 Diabetes Mellitus Patients

Saadawy

Fahmy²,

Matrawy

et al. 2019

Alexandria Dental Journal

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INTRODUCTION:One of the complications associated with diabetes mellitus is decrease in bone mineral density (BMD). Therefore, quantification of BMD for these patients before a dental implant procedure is essential. Cone beam computed tomography (CBCT) is an important tool that can be used for qualitative and quantitative bone assessment for treatment planning of dental implants. OBJECTIVES: Evaluation of mandibular bone mineral density measured by CBCT and its correlation to T-score obtained by dual energy xray absorptiometry (DEXA) in relation to blood glycemic control as detected by glycosylated hemoglobin (HbA1c) in type 2 diabetic patients (T2DM). MATERIALS AND METHODS:The study was conducted clinically on twenty-four patients having T2DM, referred for CBCT examination as a part of implant planning. BMD was measured for each edentulous mandibular space using CBCT scan. The patients were grouped according to the level of HbA1c into 4 groups; control group, well-controlled group, moderately controlled group and poorly controlled group. Additionally, each candidate was examined radio-graphically using DEXA. Then, a statistical correlation between HbA1c values in relation to mandibular BMD values and T-score values was investigated. RESULTS: there was a statistically significant correlation between HbA1c values and BMD variables including: mandibular edentulous quad BMD and T-score values (p <0.001), and a statistically significant correlation between T-score value and Mandibular edentulous quad BMD (p <0.001). CONCLUSIONS: Osteoporosis is a commonly underestimated problem in diabetes patients. Osteoporosis can be predicted using CBCT, so it's the dentist responsibility to refer osteoporotic patients once being suspected.

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Section: Discussionsupporting

confidence: 85%

Relation of Cone Beam Computed Tomography Assessment of Mandibular Bone Density to Dual Energy X-Ray Absorptiometry in Type 2 Diabetes Mellitus Patients

Saadawy

Fahmy²,

Matrawy

et al. 2019

Alexandria Dental Journal

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“…One of the factors that determine bone quality is the micro-architecture that was significantly deteriorated in the Al group according to the aforementioned histological results. Conforming to other authors [42] , the earlier mentioned Al-associated microangiopathy and atherosclerosis contributed to the reduced cell function provoking the decrease in bone mass and quality. These findings indicated the reduction of alveolar bone strength in the Al group of this study.…”

Section: Discussionsupporting

confidence: 64%

“…The reduced BMD detected in the Al group specimens complemented the osteopontin results of the resorbing bone as well as the routine histological results which illustrated the enlarged marrow spaces as an indirect measure of bone loss along with osteopenia [41] . Onoyama et al [42] asserted that bone strength is regulated by both bone density and quality. One of the factors that determine bone quality is the micro-architecture that was significantly deteriorated in the Al group according to the aforementioned histological results.…”

Section: Discussionmentioning

confidence: 99%

The possible therapeutic role of ginger extract in the effect of chronic aluminum toxicity on rat periodontium (Histological and Immunohistochemical study)

Saad

2019

Egyptian Journal of Histology

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Background: Chronic aluminum intoxication enhanced the risk for different body tissues in human and animals. Ginger administration may minimize the harmful effects of metal ions toxicity. Objective: This study has attempted to assess and compare the effects of chronic aluminum intoxication and concomitant ginger treatment on different structures of rat periodontium. Methodology: 21 adult male albino rats were divided into three equal groups: For three months; groupI received sterile 0.9% saline/day orally, groups II and III received (20mg/kg/day) aluminum chloride orally in drinking water; then, only groupIII received (150mg/kg/day) ginger oil extract orally for 4 weeks. Some of dissected mandibular halves were used for bone mineral density (BMD) measure. Other halves were decalcified and processed for H&E and immunohistochemical (using anti-CD68+ and anti-osteopontin antibodies) examination. Results: Histopathologically, groupII showed apparently decreased periodontal fibers density, wide degenerative areas and marked inflammatory infiltrates. Likewise, CD68+ was significantly expressed in giant cells in periodontal ligament (PDL) and at resorption surfaces of cementum and bone in groupII. These changes were improved in groupIII with a significant decrease of CD68+ positive cells in PDL. Cementum and bone of groupII presented significant destructive changes that were mostly restored in groupIII. Comparing to groupI, osteopontin expression in groupII significantly increased in acellular cementum(AC)>cellular cementum(CC)>bone> PDL. In comparison, this reactivity was significantly increased in bone>CC>AC in groupIII while osteopontin expression in PDL was mild but with significant increase comparing to groupI. BMD of alveolar bone was highest in groupI>groupIII>groupII with a significant differences. Conclusion:We concluded that detrimental alterations associated with chronic Al toxicity were markedly detected in PDL>bone>CC>AC that could result in serious clinical outcomes. Ginger extract greatly ameliorated these changes in bone>CC>AC>PDL confirming its strong curative potency against aluminum associated oxidative damage thus it is indicated for use in further new therapeutic approaches.

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“…Continuity of the trabecular bone structures was evaluated by star volume analysis (Vesterby et al;Vesterby;Nakamura et al;Kumasaka et al, 2000;Onoyama et al, 2011). Here, the trabecular bone structure was defined with two measurements: the trabecular star volume (V*tr) and the marrow space star volume (V*m.space).…”

Section: Methodsmentioning

confidence: 99%

Mandibular Trabecular Structures In Alveolar Ridge Preservation Using Different Grafting Materials After Tooth Extraction

2018

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The aim was to describe the star volume analysis in ridge preservation using different grafting materials. Bilateral extraction of the first mandibular molars of sixteen male rabbits was performed, divided at random into four groups (n= 4 in each group) according to graft, using: blood clot (G1), xenograft (G2), pure phase beta-tricalcium phosphate (G3) and biphasic calcium phosphate (60 % HA / 40 % beta-TCP) (G4). Rabbits were euthanized at 4, 6, or 8 wk post-extraction; the trabecular bone structures was evaluated by star volume analysis. The Levene test was used to analyze variance, as was the independent sample t-test. A P-value of < 0.001 was used to establish a statistically significant. The star volume analysis of the mandibular trabecula shows that the marrow space star volume (V*m.space) was higher than the trabecular star volume (V*tr). At 6-week post-extraction, new trabecular bone was evident. At 8-week post-extraction V*tr increase in all groups and the V*m.space diminish, suggesting coarsening of the internal architecture. In G2, some trabecular bone was observed in the central region. In G3, most of the socket regions were occupied by newly formed and loose trabecular bone and in the G4, the sockets were almost entirely filled with trabecular bone. Star volume analysis is adequate to analysis of bone patterns formation using bone substitutes.

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Comparison of mandibular trabecular structures between normal and diabetic rats: evaluation of spontaneous type 2 diabetes in a rat model

Cited by 9 publications

References 38 publications

Relation of Cone Beam Computed Tomography Assessment of Mandibular Bone Density to Dual Energy X-Ray Absorptiometry in Type 2 Diabetes Mellitus Patients

Relation of Cone Beam Computed Tomography Assessment of Mandibular Bone Density to Dual Energy X-Ray Absorptiometry in Type 2 Diabetes Mellitus Patients

The possible therapeutic role of ginger extract in the effect of chronic aluminum toxicity on rat periodontium (Histological and Immunohistochemical study)

Mandibular Trabecular Structures In Alveolar Ridge Preservation Using Different Grafting Materials After Tooth Extraction

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