Comparison of mesenchymal stem cells derived from gingival tissue and periodontal ligament in different incubation conditions

Yang, Hao; Gao, Lina; An, Yu; Hu, Cheng-Hu; Jin, Fang; Zhou, Jun; Jin, Yan; Chen, Fa‐Ming

doi:10.1016/j.biomaterials.2013.05.025

Cited by 179 publications

(223 citation statements)

References 59 publications

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“…As expected, PDLSC express numerous markers characteristic of other MSC sources, including CD146, CD105, CD90, CD29 and STRO-1 [33] . Under certain conditions, such as culture with BMP-2 or -7, PDLSC also express MSC markers such as CD44 and CD73 [30] .…”

Section: Profiling and Identitysupporting

confidence: 80%

“…PDLSC also express cementum protein 1, which is associated with a cementoblastic phenotype and reduced osteoblastic differentiation [30] . While PDLSC show mineralization under osteoinductive culture conditions, they also show multilineage differentiation potential and undergo adipogenesis or chondrogenesis under appropriate culture conditions [33] . PDLSC differ in important ways from the previously discussed DPSC, although they are often interchanged.…”

Section: Profiling and Identitymentioning

confidence: 99%

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Craniomaxillofacial Sources of Mesenchymal Stem Cells: A Brief Review

Nguyen

James

et al. 2015

International Journal of Orthopaedics

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Tissue specific mesenchymal stem cells are of great scientific interest across diverse fields in stem cell biology and medicine. Sources of mesenchymal stem cells (MSC) in the craniomaxillofacial skeleton are numerous and are of significant interest to craniofacial and oral surgeons, among other medical and dental specialties. Mesenchymal stem cells are defined by their characteristic cell surface marker expression, multipotentiality and ability for self-renewal. Bone marrow derived MSC (BMSC) are most commonly studied, but are of low abundance in the craniomaxillofacial (CMF) skeleton. Alternative CMF sources of MSC are diverse and include dental pulpal stem cells (DPSC), periodontal ligament stem cells (PDLSC), suture-derived mesenchymal stromal cells (SMC), gingival mesenchymal stem cells (GMSC)and adipose-derived MSC (ASC). This brief review will introduce various MSC sources derived from the head and neck, along with a discussion of their identity, characteristics and results of preclinical studies in tissue engineering.

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Section: Profiling and Identitysupporting

confidence: 80%

Section: Profiling and Identitymentioning

confidence: 99%

Craniomaxillofacial Sources of Mesenchymal Stem Cells: A Brief Review

Nguyen

James

et al. 2015

International Journal of Orthopaedics

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“…Gingiva from the maxillofacial region may be considered as a favorable source of mesenchymal stem cells as the harvesting of stem cells from the mandible or maxilla can be performed easily under local anesthesia (19). Furthermore, harvesting stem cells from the gingiva may be more practical when compared with the bone marrow of the maxilla and mandible as it is less invasive and has less complications, including paresthesia and pain (20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effects of Angelicae dahuricae radix on the morphology and viability of mesenchymal stem cells

Jeong

Kim

Lee

et al. 2012

Molecular Medicine Reports

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“…These results agree with other studies devoted to gingival MMSC that reported similar phenotype characteristics, differentiation potential and stable genomic behavior. 19,39,40 Also, we determined high proliferative capacity of AMC which remained constant from primary to long-term cultures. It should be noted that the population doubling time for bone marrowderived MMSC reaches only 55 § 3 hours under similar cultivation conditions.…”

Section: Discussionmentioning

confidence: 99%

Myogenic potential of human alveolar mucosa derived cells

et al. 2017

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Difficulties related to the obtainment of stem/progenitor cells from skeletal muscle tissue make the search for new sources of myogenic cells highly relevant. Alveolar mucosa might be considered as a perspective candidate due to availability and high proliferative capacity of its cells. Human alveolar mucosa cells (AMC) were obtained from gingival biopsy samples collected from 10 healthy donors and cultured up to 10 passages. AMC matched the generally accepted multipotent mesenchymal stromal cells criteria and possess population doubling time, caryotype and immunophenotype stability during long-term cultivation. The single myogenic induction of primary cell cultures resulted in differentiation of AMC into multinucleated myotubes. The myogenic differentiation was associated with expression of skeletal muscle markers: skeletal myosin, skeletal actin, myogenin and MyoD1. Efficiency of myogenic differentiation in AMC cultures was similar to that in skeletal muscle cells. Furthermore, some of differentiated myotubes exhibited contractions in vitro. Our data confirms the sufficiently high myogenic potential and proliferative capacity of AMC and their ability to maintain in vitro proliferation-competent myogenic precursor cells regardless of the passage number.

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Comparison of mesenchymal stem cells derived from gingival tissue and periodontal ligament in different incubation conditions

Cited by 179 publications

References 59 publications

Craniomaxillofacial Sources of Mesenchymal Stem Cells: A Brief Review

Craniomaxillofacial Sources of Mesenchymal Stem Cells: A Brief Review

Evaluation of the effects of Angelicae dahuricae radix on the morphology and viability of mesenchymal stem cells

Myogenic potential of human alveolar mucosa derived cells

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