Comparison of metabolic syndrome prevalence using eight different definitions: a critical approach

Reinehr, Thomas; Sousa, Gideon de; Toschke, André Michael; Andler, Werner

doi:10.1136/adc.2006.104588

Cited by 161 publications

(169 citation statements)

References 35 publications

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“…Multiple sets of criteria have been proposed and used. 32,33 We elected to use the adolescent adaptation of the ATP-III criteria because these are based on the NCEP ATP-III definition of MetS in adults. 1 MetS was defined as having at least 3 of the following: BMI z score ≥1.645, fasting glucose ≥100 mg/dL, fasting triglycerides ≥110 mg/dL, HDL ≤40 mg/dL, and systolic or diastolic BP exceeding the 90th percentile for height, age, and gender.…”

Section: Methodsmentioning

confidence: 99%

Trends in Metabolic Syndrome Severity and Lifestyle Factors Among Adolescents

2016

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Section: Methodsmentioning

confidence: 99%

Trends in Metabolic Syndrome Severity and Lifestyle Factors Among Adolescents

2016

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“…6,23,24 Most of these criteria stem from criteria used for adults; thus, abnormal results that have a low frequency in children and adolescents, such as abnormal glucose levels, may be included in the requirements for this diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…5 The prevalence of MS varies widely across several studies, and that is due to the different diagnostic criteria used. Reinehr et al 6 compared the prevalence of MS in children and adolescents using eight different definitions.…”

Section: Metabolic Syndrome: Comparison Of Diagnosis Criteriamentioning

confidence: 99%

Síndrome metabólica: comparação de critérios diagnósticos

Cavali¹,

Escrivão²,

Brasileiro³

et al. 2010

J. Pediatr. (Rio J.)

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Objective: To propose a new criterion for the diagnosis of metabolic syndrome (MS) in adolescents and to check its consistency with those proposed by Jolliffe and Janssen and by the International Diabetes Federation (IDF).Method: This is a cross-sectional study of 80 obese adolescents aged 14 to 19 years. Anthropometric (weight, height, and waist circumference) and laboratory (fasting triglycerides, HDLc, glucose, and insulin) parameters, as well as blood pressure were evaluated. The HOMA-IR index was used to characterize insulin resistance, and the presence of steatosis was assessed by hepatic ultrasound. Agreement analyses across the three criteria were made using the kappa coefficient. Results:The prevalence of MS was 13.5, 15, and 25% for IDF and Jolliffe and Janssen's criteria and the proposed method, respectively. A nearly perfect agreement between Jolliffe and Janssen's and IDF (kappa = 0.94) criteria and a moderate agreement between the new criteria and the previous two (kappa = 0.46 and 0.41, respectively) were observed. Conclusions:The highest prevalence of MS was observed with the criterion proposed in this study, which included steatosis and insulin resistance as parameters, thus being able to diagnose a larger number of adolescents at metabolic risk.J Pediatr (Rio J). 2010;86(4):325-330: Insulin resistance, hepatic steatosis, adolescents, metabolic syndrome.

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“…The metabolic syndrome (MetS) is a clustering of risk factors for CVD and T2DM (7), however, a 56 major limitation is that there is no globally accepted definition for use in paediatric populations and prevalence 57 values ranged between 6 and 39% in overweight youths according to eight different definitions (8). It is 58 hypothesised that insulin resistance may be the underlying cause of MetS (7) and viscerally located fat has a 59 3 proatherogenic function due to its metabolic and anatomical characteristics that favour insulin resistance and 60 proinflammatory and procoagulant states (7).…”

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confidence: 99%