Comparison of method-specific vancomycin minimum inhibitory concentration values and their predictability for treatment outcome of meticillin-resistant Staphylococcus aureus (MRSA) infections

Hsu, Donald I.; Hidayat, Levita; Quist, Ryan; Hindler, Janet F.; Karlsson, Åsa; Yusof, Anne; Wong-Beringer, Annie

doi:10.1016/j.ijantimicag.2008.05.007

Cited by 159 publications

(116 citation statements)

References 22 publications

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“…Some of workers postulated that the higher vancomycin MIC results provided by the E test appear to be more reliable in predicting vancomycin treatment responses. 22 CDC has adopted E test vancomycin MICs of !4 mg/ml as one of the method in screening of VISA. 12 We found, E test is more convenient method compared to agar dilution method and can be undertaken for routine clinical use.…”

Section: Resultsmentioning

confidence: 99%

In vitro vancomycin susceptibility amongst methicillin resistant Staphylococcus aureus

Chaudhari

Tandel²,

Grover

et al. 2014

Medical Journal Armed Forces India

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Methods: A prospective study was undertaken at tertiary care hospital; 232 clinical MRSA isolates were included. Vancomycin MIC was undertaken by agar dilution method and E test.Results: All isolates were sensitive to Linezolid. Two MRSA isolates had vancomycin MIC !4 mg/ml; vancomycin MIC50 and MIC90 of MRSA isolates was 0.5 and 0.2 mg/ml respectively by agar dilution method. There was agreement over 93.5% isolates in vancomycin susceptibility by agar dilution and E test. E test had sensitivity and positive predictive value of 1.0 (CI e 0.34e1.0) and 0.5 (CI e 0.17e0.83) respectively compare to agar dilution method.

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Section: Resultsmentioning

confidence: 99%

In vitro vancomycin susceptibility amongst methicillin resistant Staphylococcus aureus

Chaudhari

Tandel²,

Grover

et al. 2014

Medical Journal Armed Forces India

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“…Recent reports describe discrepancies in the ability of automated systems to accurately determine the MIC of vancomycin against MRSA compared with Etest or reference BMD methods [8,24]. A recent study comparing four commercial MIC testing systems (MicroScan, VITEK 1 2, Phoenix and Etest) against the Clinical and Laboratory Standards Institute (CSLI) reference BMD method showed 61.8%, 54.3%, 66.2% and 36.7% absolute agreement (0 AE dilution) with the BMD method, respectively [8].…”

Section: Methodology For Determination Of the Vancomycin Minimum Inhimentioning

confidence: 99%

Treatment options for methicillin-resistant Staphylococcus aureus (MRSA) infection: Where are we now?

Edwards

Andini

Esposito

et al. 2014

Journal of Global Antimicrobial Resistance

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“…[27][28][29] Several authors have postulated that higher MIC values provided by the E-Test is more reliable in predicting vancomycin treatment response. 30 CDC has approved Etest for detection of vancomycin resistance. 29 As routine use of agar dilution is cumbersome and labour intensive.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, increased vancomycin MIC has been correlated with adverse clinical outcomes in some studies. 30,39 Therefore alternative therapies should be employed where vancomycin MIC is >1 μgm/ml to avoid treatment failure. Antimicrobial agents effective against VISA and VRSA includes linezolid, daptomycin, tigecycline, quinupristin/dalfopristin, and also in vitro activity against VISA and VRSA have been demonstrated by dalbavancin, telavancin, oritavancin, ceftobiprole, and iclaprim.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic susceptibility pattern of Staphylococcus aureus in tertiary care hospital, SRMSIMS, Bareilly, U.P.

Gupta¹,

Pachori²,

Goyal

2017

Int J Community Med Public Health

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Background: S. aureus has been recognized as continuously challenging the clinicians despite the availability of antibiotics from nearly 70 yrs and emergence of various types of antibiotic resistance mechanisms especially to methicillin and vancomycin, which was the theme of this study. The study was to determine the antibiotic susceptibility of Staphylococcus aureus in Tertiary Care Hospital, SRMSIMS, Bareilly and also to determine the current status of Vancomycin susceptibility in our Hospital setup considering E-Test as gold standard.Methods: This study was prospective in design from 1st January 2014 to 31st December 2014 and conducted in the Department of Microbiology, SRMSIMS, Bareilly. All S. aureus strains were screened for vancomycin resistance by Dual strip E- test.Results: Out of 505 Staphylococcus aureus isolates, we found that MRSA, VISA, and VRSA as 80.8%, 0.6% and 0.0% respectively. In cases of MRSA, antibiogram showed sensitivity in the range of 99.4 -100% for glycopeptides, and sensitivity to levofloxacin, chloramphenicol was 77.5% and 65.2% respectively.Conclusions: On evaluation of MIC by E-strips, we found that 17% of MRSA were showing MIC values quite near to the MIC value of VISA. So, these strains may convert to VISA, if the injudicious use of vancomycin antibiotics is not stopped.

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Comparison of method-specific vancomycin minimum inhibitory concentration values and their predictability for treatment outcome of meticillin-resistant Staphylococcus aureus (MRSA) infections

Cited by 159 publications

References 22 publications

In vitro vancomycin susceptibility amongst methicillin resistant Staphylococcus aureus

In vitro vancomycin susceptibility amongst methicillin resistant Staphylococcus aureus

Treatment options for methicillin-resistant Staphylococcus aureus (MRSA) infection: Where are we now?

Antibiotic susceptibility pattern of Staphylococcus aureus in tertiary care hospital, SRMSIMS, Bareilly, U.P.

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