Comparison of methods for evaluating surface properties of lung in perinatal period.

Gandy, Gillian; Bradbrooke, J. G.; Naidoo, Bianca; Gairdner, Douglas

doi:10.1136/adc.43.227.8

Cited by 25 publications

(10 citation statements)

References 11 publications

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“…Bubble clicking occurs in lung foam (20,21) and is absent in bubbles from the lungs of babies who die from hyaline membrane disease (8). We first observed clicking in amniotic fluid bubbles (17,18) and pharyngeal aspirate (19); the results correlated with the L/S ratio and incidence o f RDS.…”

Section: Introductionmentioning

confidence: 64%

Bubble Clicking in Pharyngeal Aspirate Compared with Lecithin/Sphingomyelin Ratio

Parkinson¹,

Supramaniam²,

Harvey³

1978

Neonatology

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Tracheal fluid flows into the pharynx, so surfactant can be measured in pharyngeal aspirate. The walls of bubbles in air-free water show rhythmic movements (bubble clicking) if they contain surfactant. Babies with respiratory distress syndrome (RDS) have very little lung surfactant which can be shown by a low lecithin/sphingomyelin (L/S) ratio. To investigate surfactant in newborn babies we analysed 125 pharyngeal aspirates for the L/S ratio and bubble clicking. Both tests became more positive towards term and were related to the incidence of RDS. Babies with birth asphyxia or mild respiratory difficulties had lower L/S ratios and less clicking than normal babies. Both investigations could be used to chart the course of RDS. The L/S ratio is a chemical measurement of surfactant. Bubble clicking, which takes only a few minutes, demonstrates surface tension effects.

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Section: Introductionmentioning

confidence: 64%

Bubble Clicking in Pharyngeal Aspirate Compared with Lecithin/Sphingomyelin Ratio

Parkinson¹,

Supramaniam²,

Harvey³

1978

Neonatology

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“…

In the preceding paper (Gandy, Jacobson, and but are not found in infants dying from hyaline Gairdner, 1970) histological studies of human lung membrane disease (HMD) in the first few days of have shown that the presence of osmiophilic life. However, the role of surfactant deficiency in granules correlates well with the presence of HMD remains debatable; though such deficiency surfactant.

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mentioning

confidence: 98%

“…of a saline extract of lung homogenate was measured on a Wilhelmy balance as described previously (Gandy et al, 1968).…”

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confidence: 99%

Hyaline Membrane Disease: II: Lung Lecithin

Boughton¹,

Gandy²,

Gairdner³

1970

Archives of Disease in Childhood

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“…In addition, the stability of bubbles expressed from lung tissue was examined in 56/84 cases; the presence or absence of bubble 'clicking' was noted in all 56, the bubble stability ratio (SR) was determined in 40 cases. The methods used for these measurements were those previously described (Gandy et al, 1968).…”

mentioning

confidence: 99%