Comparison of MicroRNA Expression in Tears of Normal Subjects and Sjögren Syndrome Patients

Kim, Yu Jeong; Yeon, Yeji; Lee, Won June; Shin, Yong Un; Cho, Heeyoon; Sung, Yoon‐Kyoung; Kim, Du Roo; Lim, Han Woong; Kang, Min Ho

doi:10.1167/iovs.19-27062

Cited by 46 publications

(32 citation statements)

References 54 publications

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“…SS dry eye is a multifactorial disease, including genetic predisposition, environmental and epigenetic factors [12]. Recently, accumulating evidences have revealed that miRs are dysregulated in tears, PBMCs, and salivary gland of patients with SS [15,17,24]. Nevertheless, the miRs profiling in LGs of SS dry eye remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…International Publisher patients and experimental animal models have shown that the dysregulation of miRs was closely related to the development of autoimmune diseases, including SS dry eye [11,12]. miRs have been shown to be differentially expressed in the tears, peripheral blood mononuclear cells (PBMCs) and salivary glands from SS patients [13][14][15]. For example, Shi et al demonstrated that the expression of miR-146a is upregulated and miR-155 is downregulated in PBMCs of patients with SS, and the expression levels of these miRs are correlated with the visual analog scale scores for dry eye [16].…”

Section: Ivyspringmentioning

confidence: 99%

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MicroRNA expression profile of Lacrimal Glands in rabbit autoimmune dacryoadenitis model

et al. 2020

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Purpose: To identify the differential expression of microRNAs (miRs) and the related gene networks and signal pathways in lacrimal glands (LGs) of rabbit autoimmune dacryoadenitis. Methods: Autoimmune dacryoadenitis in rabbits was induced by transferring activated peripheral blood lymphocytes (PBLs). The LGs of normal and model group rabbits were collected for small RNA sequencing. The most differentially expressed miRs were validated by quantitative real time-polymerase chain reaction (qRT-PCR). Further, bioinformatics analysis including target gene prediction, Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Results: A total of 15 miRs were differentially expressed in the LGs of rabbit autoimmune dacryoadenitis relative to normal controls. GO and KEGG analysis revealed that most target genes of these dysregulated miRs were implicated in MAPK signaling pathway. Conclusion: Our results showed for the first time the differentially expressed miRs and the related pathways involved in the pathogenesis of rabbit autoimmune dacryoadenitis. These results may contribute to elucidating molecular pathogenesis of Sjögren's syndrome (SS) dry eye.

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Section: Discussionmentioning

confidence: 99%

Section: Ivyspringmentioning

confidence: 99%

MicroRNA expression profile of Lacrimal Glands in rabbit autoimmune dacryoadenitis model

et al. 2020

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“…Less invasive samples, such as saliva or sputum are often preferred over blood or sera. Indeed, miRNAs have been found in almost all biofluids, including saliva (Min et al, 2018), urine (Ben-Dov et al, 2014, breast milk (Kelleher et al, 2019), and tears (Kim et al, 2019), however, the use of these less invasive sample types would depend on the underlying disease. For example, salivary miRNAs may be useful for the diagnosis of mouth infections (Min et al, 2018) but may not be useful for infections in other areas of the body.…”

Section: Validation and Translation Of Mirna Diagnosticsmentioning

confidence: 99%

MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing

et al. 2020

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In the pursuit of improved diagnostic tests for infectious diseases, several classes of molecules have been scrutinized as prospective biomarkers. Small (18-22 nucleotide), non-coding RNA transcripts called microRNAs (miRNAs) have emerged as promising candidates with extensive diagnostic potential, due to their role in numerous diseases, previously established methods for quantitation and their stability within biofluids. Despite efforts to identify, characterize and apply miRNA signatures as diagnostic markers in a range of non-infectious diseases, their application in infectious disease has advanced relatively slowly. Here, we outline the benefits that miRNA biomarkers offer to the diagnosis, management, and treatment of infectious diseases. Investigation of these novel biomarkers could advance the use of personalized medicine in infectious disease treatment, which raises important considerations for validating their use as diagnostic or prognostic markers. Finally, we discuss new and emerging miRNA detection platforms, with a focus on rapid, point-of-care testing, to evaluate the benefits and obstacles of miRNA biomarkers for infectious disease.

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“…In addition to serum, tear is also applicable as a source for circulating miRNAs. Recently, Kim et al (2019) revealed four miRNAs being upregulated and 10 miRNAs being downregulated in tear samples of SS patients, indicating that tear miRNAs may provide clues to the pathogenesis of lacrimal gland dysfunction in SS patients. Hence, it seems that finding of new circulating miRNAs shows significant promise for the diagnosis or understanding of biology processes in autoimmunemediated eye diseases.…”

Section: Circulating Micrornas As Biomarkers For Autoimmune-mediated mentioning

confidence: 99%

MicroRNAs and Autoimmune-Mediated Eye Diseases

Wei

Zhao

et al. 2020

Front. Cell Dev. Biol.

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MicroRNAs (miRNAs) are evolutionarily conserved short non-coding RNAs that act at post-transcriptional regulation of gene expression by destroying target messenger RNA or inhibiting its translation. Recently, miRNAs have been identified as important regulators in autoimmunity. Aberrant expression and function of miRNAs can lead to dysfunction of immune system and mediate autoimmune disorders. Here, we summarize the roles of miRNAs that have been implicated in three representative ocular autoimmune disorders, including autoimmune uveitis, Grave's ophthalmopathy, and Sjögren's syndrome dry eye, and discuss the potential of miRNAs as biomarkers and therapeutic targets for the diagnosis and treatment of these diseases.

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Comparison of MicroRNA Expression in Tears of Normal Subjects and Sjögren Syndrome Patients

Cited by 46 publications

References 54 publications

MicroRNA expression profile of Lacrimal Glands in rabbit autoimmune dacryoadenitis model

MicroRNA expression profile of Lacrimal Glands in rabbit autoimmune dacryoadenitis model

MicroRNA Biomarkers for Infectious Diseases: From Basic Research to Biosensing

MicroRNAs and Autoimmune-Mediated Eye Diseases

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