Comparison of mitomycin-c and heparin affects in experimental corrosive esophagitis on rats

Şentürk, Ekrem; Pabuşçu, Engin; Sen, Sayan; Ünsal, Cengiz

doi:10.1016/j.ijporl.2011.03.007

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…In the literature, various substances have been used in order to promote recovery in caustic oesophagitis (heparin [17], vitamin E [18], caffeic acid phenethyl ester [19], F mitomycin C [20], etc.) We examined the effectiveness of TQ, zeolite, and PRP whose effectiveness in oesophagitis has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats

et al. 2017

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PurposeThe effectiveness of platelet-rich plasma (PRP), thymoquinone, and zeolite in corrosive esophageal burns was investigated in a rat model.MethodsFour groups were comprised as containing 10 rats in each group. For group I, oesophagitis was induced and no other procedure was performed (control group). For group II, oesophagitis was induced and thymoquinone was administered for 1 week via oral gavage once a day (thymoquinone group). For group III, oesophagitis was induced for 1 week via oral gavage once a day (PRP group). For group IV, oesophagitis was induced and zeolite was administered for 1 week via oral gavage once a day (zeolite group). On the 10th day, the rats were sacrificed under anaesthesia and venous blood sampling was performed from the vena portae. The oesophaguses were totally excised. Biochemically, interleukin (IL)-1B, IL-6, TNF-α, and MCP-1 were examined from venous blood. Inflammation score was evaluated histopathologically in oesophageal tissue that was collected.ResultsThere was a statistically significant difference among groups in terms of IL-1, IL-6, MCP levels, compared to the control group; median IL-1, IL-6, MCP levels of thymoquinone, PRP, and zeolite groups were statistically significantly lower. There was a statistically significant difference among groups in terms of inflammation scores, compared to group I; median inflammation scores of groups II, III and IV were statistically significantly lower thymoquinone.ConclusionPRP, and zeolite exhibited positive effect on recovery in oesophagitis by reducing inflammation in the involved segment.

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Section: Introductionmentioning

confidence: 99%

Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats

et al. 2017

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“…Application of Mitomycin C resulted in significantly less scar tissue formation compared with placebo treatment in a rodent model of caustic esophageal injury (►Table 1). [33][34][35] In this article, we report the results of a systematic analysis of all published pediatric cases regarding the therapeutic application of Mitomycin C in esophageal stricture and stenosis.…”

Section: Introductionmentioning

confidence: 99%

Mitomycin C in the Therapy of Recurrent Esophageal Strictures: Hype or Hope?

2012

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“…Fibrous tissue is the cause of the formation of the esophageal stricture in the chronic pe-riod [5,26,27]. To prevent stricture formation and treat corrosive esophageal burn (CEB) injury, ketotifen [33], tamoxifen [34], Ankaferd Blood Stopper [35], carvacrol [36], hypericum perforatum oil [37], contractubex [30], ethyl pyruvate, N-acetyl cysteine [38], platelet-rich plasma [39], alpha lipoic [40], bromelain [41], hesperidin [42] and mitomycin C [43] were studied. Due to its antioxidant, anti-inflammatory, antifibrotic [44], antitumoral [45], antiviral [46] and antidiabetic [47] effects, this study investigated the efficacy of Ellagic acid (EA) for the treatment of CEB injury, as previous experimental studies explored various therapeutic agents.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury

Keşim,

Aşır,

Ayaz

et al. 2024

CIMB

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This study aimed to investigate the antioxidant effect of Ellagic acid (EA) on wound healing in sodium hydroxide (NaOH)-induced corrosive esophageal burn injury. The interaction networks and functional annotations were conducted using Cytoscape software. A total of 24 Wistar albino rats were divided into control, corrosive esophageal burn (CEB) and CEB + EA groups. Burn injury was created by 20% NaOH and 30 mg/kg EA was per oral administered to rats. At the end of the 28-day experimental period, Malondialdehyde (MDA) content was measured. Esophageal tissue samples were processed for histological staining. The EA–target interaction network was revealed to be involved in regulating crucial cellular mechanisms for burn wound healing, with epidermal growth factor (EGF) identified as a central mediator. An increase in animal weight in the CEB + EA group was observed in the EA-treated group after CEB injury. Burn injury increased MDA content, but EA treatment decreased its level after CEB injury. Stenosis index, collagen degeneration, inflammation, fibrosis and necrosis levels were increased after CEB injury. EA treatment improved histopathology in the CEB + EA group compared to the CEB group. The expression of EGF was decreased in the CEB group but upregulated in the EA-treated group, suggesting a potential involvement of EA in cellular processes and tissue regeneration. EA, through its antioxidative and tissue regenerative properties, significantly contributes to alleviating the adverse effects of CEB injury, promoting wound healing.

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Comparison of mitomycin-c and heparin affects in experimental corrosive esophagitis on rats

Cited by 8 publications

References 21 publications

Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats

Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats

Mitomycin C in the Therapy of Recurrent Esophageal Strictures: Hype or Hope?

The Effects of Ellagic Acid on Experimental Corrosive Esophageal Burn Injury

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