Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats

Abstract

PurposeThe effectiveness of platelet-rich plasma (PRP), thymoquinone, and zeolite in corrosive esophageal burns was investigated in a rat model.MethodsFour groups were comprised as containing 10 rats in each group. For group I, oesophagitis was induced and no other procedure was performed (control group). For group II, oesophagitis was induced and thymoquinone was administered for 1 week via oral gavage once a day (thymoquinone group). For group III, oesophagitis was induced for 1 week via oral gavage once a day (PRP group). For group IV, oesophagitis was induced and zeolite was administered for 1 week via oral gavage once a day (zeolite group). On the 10th day, the rats were sacrificed under anaesthesia and venous blood sampling was performed from the vena portae. The oesophaguses were totally excised. Biochemically, interleukin (IL)-1B, IL-6, TNF-α, and MCP-1 were examined from venous blood. Inflammation score was evaluated histopathologically in oesophageal tissue that was collected.ResultsThere was a statistically significant difference among groups in terms of IL-1, IL-6, MCP levels, compared to the control group; median IL-1, IL-6, MCP levels of thymoquinone, PRP, and zeolite groups were statistically significantly lower. There was a statistically significant difference among groups in terms of inflammation scores, compared to group I; median inflammation scores of groups II, III and IV were statistically significantly lower thymoquinone.ConclusionPRP, and zeolite exhibited positive effect on recovery in oesophagitis by reducing inflammation in the involved segment.

Thymoquinone Attenuates Cardiomyopathy in Streptozotocin‐Treated Diabetic Rats

“…On the contrary, TQ lowered the plasma levels of E-selectin, CRP, and IL-6. This result agreed with Karaca et al [ 33 ], who noticed a significant reduction in interleukin-1 beta (IL-1 β ), IL-6, tumor necrosis factor-alpha (TNF- α ), and monocyte chemoattractant protein-1 (MCP-1) in rats subjected to experimental induction of esophagitis. Also, it was found that TQ has a role against inflammatory progression in the hippocampal tissues due to lipopolysaccharide-induced inflammation in rats [ 34 ].…”

Evaluation of prophylactic and therapeutic effects of ruscogenin on acute radiation proctitis: an experimental rat model

“…ARP is an inducible inflammation. Macroscopical, histopathological, and immunohistochemical analyses have been performed to determine this inflammation [ 15 16 17 18 19 20 21 22 ]. In this study, to show the inflammation, markers of IL-1β, TNF-α, and HIF1α cytokines were investigated; to show fibrosis in the rectal tissue, FGF2 was used as a marker and VEGF marker was used to show angiogenesis.…”

“…In addition, it activates the vascular endothelial cells [ 19 ]. TNF has an effect of oxidative damage on endothelial cells and increases the number of adhesion molecules; it also induces angiogenesis and arranges hematopoiesis [ 20 ]. Moreover, angiogenesis and endothelial cell proliferation can also be induced by FGF or VEGF [ 21 23 ].…”

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“…TQ and PRP composites with zeolite showed positive outputs on recovery in esophagitis by lessoning inflammation in the contacted area. 109 Moreover, proper oxygen supply to cells is a challenging issue in tissue engineering scaffolds. Ninan et al fabricate scaffold based on gelatin/copper‐faujasites (CAF) as a wound dressing.…”