Comparison of modern marker proteins in serum and synovial fluid in patients with advanced osteoarthrosis and rheumatoid arthritis

Abstract

Numerous studies have focused on the significance of modern marker proteins in the synovial fluid of the knee joint and in the serum both, for osteoarthritis (OA) and rheumatoid arthritis (RA). The relationship between the serum concentrations and the concentrations in the synovial fluid is still unclear. Synovial fluid and serum samples were obtained from 13 patients with advanced OA and from 8 patients with severe RA and concentrations of MMP-1, MMP-3, MMP-13, TIMP-1, COMP and MIA/CD-RAP were determined. All values were normalized against the total protein concentrations. Serum concentrations of MMP-13 in the RA-group were statistically higher than the synovial values (P<0.05). MMP-13 was the only marker protein that revealed distinct higher levels in the serum than in the synovial fluid. The study design allows only conclusions about advanced stages of RA and OA. Longitudinal investigations may provide further information about the value of MMP-13 as a potential marker to monitor the course of RA and OA.

Cartilage Oligomeric Matrix Protein Levels in Synovial Fluid in Patients With Primary Knee Osteoarthritis And Healthy Controls: A Preliminary Comparative Analysis With Serum Cartilage Oligomeric Matrix Protein

“…Similar results were found by El-Arman et al, 21 Gheita et al, 22 and Andereya et al, 23 suggesting that COMP is produced in the joint and associated Some studies have concluded that serum COMP levels vary between sexes and among different ethnicities. 6,24 Indeed, COMP levels may vary in biologic fluids, due to several factors.…”

Gene expression of leucocytes in vaccinated Japanese flounder (Paralichthys olivaceus) during the course of experimental infection with Edwardsiella tarda

“…Also, it has been used as a marker for the induction state in inflammation, including auto-immune diseases, cancer [20], and intra-amniotic infection [23]. MMP-13 has also been evaluated as a potential marker to monitor the cause of arthritis [24] and cancer [25]. MMPs may be a useful marker of pathological conditions in Japanese flounder as these enzymes up-regulated in the course of E. tarda infection.…”

Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers

“…We were unable to detect MMP-13 in any of the 259 RA serum samples tested, and other investigators detected MMP-13 in only 9 of 56 RA sera (14). In studies of patients with juvenile idiopathic arthritis, MMP-13 was also undetectable in serum and synovial fluid (26), while other authors have detected MMP-13 in the serum of patients with osteoarthritis (27,28). It has been suggested that levels of MMP-13 in RA patients may be low due to active removal and degradation by chondrocytes and synoviocytes via a specific surface MMP-13 receptor (29)(30)(31).…”