Comparison of monocyte-dependent T cell inhibitory activity in GM-CSF vs G-CSF mobilized PSC products

Ageitos, AG; Varney, Michelle L.; Pj, Bierman; Vose, J. M.; Warkentin, Phyllis; Talmadge, J. E.

doi:10.1038/sj.bmt.1701524

Cited by 41 publications

(29 citation statements)

References 38 publications

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“…Apoptosis provides one mechanism for the regulation of peripheral CD4 positive T-cell homeostasis. Recent studies suggested that T-cell apoptosis is associated with T-cell activation by either CD3 positive cross-linking, phorbol myristate acetate, or phytohemagglutinin (25,26,(29)(30)(31)(32). This occurs through a MHC nonrestricted monocytedependent mechanism (33).…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies suggested that T-cell apoptosis is associated with T-cell activation by either CD3 positive cross-linking, phorbol myristate acetate, or phytohemagglutinin (25,26,(29)(30)(31)(32). This occurs through a MHC nonrestricted monocytedependent mechanism (33). The requirement for T-cell activation seems to be a common feature of monocyte-dependent apoptosis mediated by Fas-FasL interaction (30,34,35).…”

Section: Discussionmentioning

confidence: 99%

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Pleural Cryptococcosis with Idiopathic CD4 Positive T-lymphocytopenia

et al. 2004

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A 19-year-old man was admitted to our hospital because of chest pain. He was diagnosed as having pleural cryptococcosis by pleural biopsy. His CD4 positive Tlymphocyte count was low (<300 µl) and there was no evidence of human immunodeficiency virus infection. He was successfully treated with fluconazole. However, his CD4 positive lymphocyte counts remained low after the recovery and he was diagnosed as idiopathic CD4 positive T-lymphocytopenia. Pleural cryptococcosis is rare and its predisposing condition is still controversial. To our knowledge, this is the first case of pleural cryptococcosis associated with idiopathic CD4 positive T lymphocytopenia. (Internal Medicine 43: 977-981, 2004)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pleural Cryptococcosis with Idiopathic CD4 Positive T-lymphocytopenia

et al. 2004

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“…In addition, G-CSF has been shown to increase activation markers on these mobilized cells. 86 Once activated, monocytes in the graft can inhibit T-cell function 87,88 via IL-10 production. 89 Consequently, a shift toward Th2 cytokine production occurs post transplant and may be advantageous for reducing acute GVHD, 90 in which Th1-producing cytokines cause cytotoxic damage to host tissues.…”

Section: Recovery Of Adaptive Immunitymentioning

confidence: 99%

Immune restoration following hematopoietic stem cell transplantation: an evolving target

Auletta

Lazarus

2005

Bone Marrow Transplant

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Summary:Hematopoietic stem cell transplantation (HSCT) is the definitive cure for many malignant and nonmalignant diseases. However, delays in immune reconstitution (IR) following HSCT significantly limit the success of transplantation and increase the risk for infection and disease relapse in the transplant recipient. Therefore, ways to measure and to manipulate immune recovery following HSCT are emerging and their success depends directly upon an enhanced understanding for the underlying mechanisms responsible for reconstituted immunity and hematopoiesis. Recent discoveries in the activation, function, and regulation of dendritic cell (DC), natural killer (NK) cell, and T-lymphocyte subtypes have been critical in developing immunotherapies used to prevent graft-versushost disease and to enhance graft-versus-leukemia. For example, regulatory T cells that induce tolerance and NK receptor-tumor ligand disparities that result in tumor lysis are being used to minimize GVHD and tumor burden, respectively. Furthermore, expansion and modulation of immune effector cells are being used to augment hematopoietic and immune recovery and to decrease transplantrelated toxicity in the transplant recipient. Specifically, DC expansion and incorporation into antitumor and antimicrobial vaccines is fast approaching application into clinical trials. This paper will review our current understanding for IR following HSCT and the novel ways in which to restore immune function and decrease transplantrelated toxicity in the transplant recipient. Bone Marrow Transplantation (2005) 35, 835-857.

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“…6,7 In vitro human studies have demonstrated that PBSC products have high levels of T cell inhibitory activity. [8][9][10][11][12][13] This effect has been variously attributed to the high levels of IL-10 produced by monocytes, 14 to modulation of monocyte function, 15 and more recently, to a mobilisation-associated increase in certain dendritic cell (DC) subsets. 16,17 DC constitute a system of antigen-presenting cells that play a critical role in regulating immune responses.…”

mentioning

confidence: 99%

Differential effects of G-CSF mobilisation on dendritic cell subsets in normal allogeneic donors and patients undergoing autologous transplantation

Hock

Haring

Ebbett

et al. 2002

Bone Marrow Transplant

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Summary:It has been suggested that the immunological properties of cytokine primed PBSC may reflect the presence of altered levels of cellular components. In this study the changes induced in blood dendritic cell (DC) subsets following G-CSF mobilisation are analysed. Analysis of normal donors (n = 64) demonstrated considerable individual variation in the absolute numbers (؋10 6 /l) of resting blood CD11c ؊ DC (1.2-26.2) and CD11c + DC (0.9-34.7) as well as in the CD11c ؊ /CD11c + DC ratio (0.29-4.13). G-CSF therapy increased CD11c ؊ DC numbers to above the normal range in all normal donors analysed (n = 6) and the CD11c ؊ /CD11c + ratio was also increased to Ͼ2.0 in all donors. Patients undergoing autologous PBSCT showed a heterogeneous response to mobilisation and although total DC and CD11c ؊ DC numbers were increased in the majority (8/14), they remained within the normal range post mobilisation. The CD11c ؊ /CD11c + ratio decreased in 5/15 patients and only three patients had ratios Ͼ2.0 post mobilisation. Post G-CSF the DC from all normal donors and 13/14 patients had an immature phenotype. These results demonstrate that G-CSF mobilisation induces relatively consistent changes in the number and ratio of DC subsets in normal donors, but considerable variation is seen in the response of patients undergoing mobilisation for autologous PBSCT.

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Comparison of monocyte-dependent T cell inhibitory activity in GM-CSF vs G-CSF mobilized PSC products

Cited by 41 publications

References 38 publications

Pleural Cryptococcosis with Idiopathic CD4 Positive T-lymphocytopenia

Pleural Cryptococcosis with Idiopathic CD4 Positive T-lymphocytopenia

Immune restoration following hematopoietic stem cell transplantation: an evolving target

Differential effects of G-CSF mobilisation on dendritic cell subsets in normal allogeneic donors and patients undergoing autologous transplantation

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