Comparison of moxalactam (LY127935) and cefotaxime against anaerobic bacteria

Jorgensen, J. H.; Crawford, S. A.; Alexander, G A

doi:10.1128/aac.17.5.901

Cited by 41 publications

(19 citation statements)

References 7 publications

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“…Our results with moxalactam were similar to those reported by Jorgensen, Crawford andAlexander (1980) andBrown et al (1981) except that several strains of Bacteroides in our series had MICs > 64 pg/ml. Most strains of Fusobacteriurn spp.…”

Section: Discussionsupporting

confidence: 81%

Susceptibility of anaerobic bacteria to beta-lactam antibiotics and beta-lactamase production

Aldridge

Sanders

Lewis

et al. 1983

Journal of Medical Microbiology

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Section: Discussionsupporting

confidence: 81%

Susceptibility of anaerobic bacteria to beta-lactam antibiotics and beta-lactamase production

Aldridge

Sanders

Lewis

et al. 1983

Journal of Medical Microbiology

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“…Cefoperazone, cefotaxime, ceftizoxime, and ceftazidime are recently introduced cephalosporins which differ from their predecessors, such as cefoxitin, by alterations of the basic cephalosporin nucleus and its substituent groups. These new cephalosporins have been reported to have broader spectrum of activity than older agents and relative resistance to hydrolysis by beta-lactamases (10,16,20,26). In this investigation, cefoxitin, a beta-lactamase-resistant cephamycin, was level.…”

Section: Resultsmentioning

confidence: 99%

Comparative In Vitro Activity of New Beta-Lactam Antibiotics Against Anaerobic Bacteria

Rolfe

Finegold

1981

Antimicrob Agents Chemother

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Several new beta-lactam antimicrobial agents have been introduced in the last few years. In this investigation, the in vitro activities of several recently introduced cephalosporins (cefoperazone, cefotaxime, ceftazidime, and ceftizoxime), moxalactam, and N-formimidoyl thienamycin were compared with those of cefoxitin, clindamycin, and metronidazole against 203 strains of anaerobic bacteria. At achievable serum levels, all of the antimicrobial agents were active against essentially 100% of the strains of anaerobic gram-positive cocci, Clostridium perfringens, Leptotrichia buccalis, and species of Selenomonas, Veillonella, and Eubacterium. Clindamycin, metronidazole, and N-formimidoyl thienamycin were the most active agents against the Bacteroides fragilis group, inhibiting all strains at concentrations which can be achieved in serum. Of the remaining agents tested against the B. fragilis group, cefoxitin (which required 64 ,tg/ml to inhibit 90% of the strains) was the most active, followed by cefoperazone (128 ,ug/ml), cefotaxime (128 ,tg/ml), moxalactam (128 ,ug/ml), ceftizoxime (256 ,ug/mi), and ceftazidime (>256 pg/ml). Important differences in cephalosporin susceptibility among species of the B. fragilis group were observed. Metronidazole and N-formimidoyl thienamycin were the most active drugs against species of clostridia other than C. perfringens; the other antibiotics displayed poor activity, although this is partly due to inclusion of a relatively large number of strains of Clostridium difficile which were very resistant to several of the cephalosporins. Only metronidazole was active against all species of Fusobacterium. Clindamycin and N-formimidoyl thienamycin displayed excellent activity against gram-positive, non-spore-forming bacilli, requiring c8 ytg/ml to inhibit 100% of the strains. Ceftazidime, cefoperazone, and moxalactam were bactericidal for 25 strains of B. fragilis at concentrations equal or close to those required for inhibition. On the basis of its activity in vitro, N-formimidoyl thienamycin appears to be the most promising of the new beta-lactam antibiotics for the treatment of infections involving anaerobic bacteria.Several new beta-lactam antibiotics have been introduced in the last few years. Several recently introduced cephalosporins, including ceftizoxime, cefoperazone, cefotaxime, and ceftazidime, are distinguished from earlier cephalosporins by increased resistance to beta-lactamase degradation and extended antibacterial spectrum. N-formimidoyl thienamycin, a stable derivative of thienamycin, and moxalactam are beta-lactam antibiotics with potent and broad-spectrum activities.The purpose of the present study was to examine the in vitro activity of these new compounds against various strains of anaerobic bacteria. Using an agar dilution technique, the act Present address:

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“…The fact that many of the new antibiotics are effective against a wider range of bacteria than most of the currently used antibiotics suggests that one or more of these may be useful in a single-agent regimen. However, although many in vitro studies have shown that these antibiotics inhibit the aerobic organisms common to obstetric and gynecological infections (1,(12)(13)(14), there are few and only limited studies (6,7,9) of the effectiveness of these antibiotics against species of anaerobic bacteria, such as Bacteroides bivius and anaerobic gram-positive cocci, commonly isolated from pelvic infections (3,4 In an effort to expand on the above experience, we determined the minimal inhibitory concentrations (MICs) of cefoperazone, cefotaxime, cefoxitin, chloramphenicol, clindamycin, N-formimidoyl thienamycin, metronidazole, moxalactam, penicillin G, and piperacillin for 158 anaerobic bacteria isolated from endometrial wash cultures of 56 women admitted to San Francisco General Hospital with untreated pelvic infections (mostly salpingitis and endometritis). The organisms, identified through the use of gas-liquid chromatography and prereduced anaerobically sterilized media (5), were either recent isolates maintained in chopped meat broth or subcultures of isolates frozen in 10% skim milk at -70°C.…”

mentioning

confidence: 99%

In vitro activity of new beta-lactam antibiotics and other antimicrobial drugs against anaerobic isolates from obstetric and gynecological infections

Ohm‐Smith¹,

Hadley²,

Sweet³

1982

Antimicrob Agents Chemother

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The in vitro activities of N-formimidoyl thienamycin, clindamycin, chloramphenicol, metronidazole, cefoperazone, cefotaxime, cefoxitin, moxalactam, penicillin G, and piperacillin were determined against 158 anaerobic bacteria isolated from endometrial wash cultures of women with pelvic infections. In general, Nformimidoyl thienamycin was the most active, with all organisms inhibited by cO.5 jig/ml. Chloramphenicol, clindamycin, and metronidazole inhibited all organisms by c8 ,ug/ml. The penicillins and cephalosporins exhibited variable activity of lesser degrees.Infections of the female genital tract are often of mixed aerobic/anaerobic bacterial etiology (2-4, 11). Thus, it is frequently necessary to use a combination of antibiotics to inhibit the variety of bacteria present, although treatment with a single antibiotic would be preferable. The fact that many of the new antibiotics are effective against a wider range of bacteria than most of the currently used antibiotics suggests that one or more of these may be useful in a single-agent regimen. However, although many in vitro studies have shown that these antibiotics inhibit the aerobic organisms common to obstetric and gynecological infections (1,(12)(13)(14), there are few and only limited studies (6, 7, 9) of the effectiveness of these antibiotics against species of anaerobic bacteria, such as Bacteroides bivius and anaerobic gram-positive cocci, commonly isolated from pelvic infections (3,4 no. 107, 1981).In an effort to expand on the above experience, we determined the minimal inhibitory concentrations (MICs) of cefoperazone, cefotaxime, cefoxitin, chloramphenicol, clindamycin, N-formimidoyl thienamycin, metronidazole, moxalactam, penicillin G, and piperacillin for 158 anaerobic bacteria isolated from endometrial wash cultures of 56 women admitted to San Francisco General Hospital with untreated pelvic infections (mostly salpingitis and endometritis). The organisms, identified through the use of gas-liquid chromatography and prereduced anaerobically sterilized media (5)

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Comparison of moxalactam (LY127935) and cefotaxime against anaerobic bacteria

Cited by 41 publications

References 7 publications

Susceptibility of anaerobic bacteria to beta-lactam antibiotics and beta-lactamase production

Susceptibility of anaerobic bacteria to beta-lactam antibiotics and beta-lactamase production

Comparative In Vitro Activity of New Beta-Lactam Antibiotics Against Anaerobic Bacteria

In vitro activity of new beta-lactam antibiotics and other antimicrobial drugs against anaerobic isolates from obstetric and gynecological infections

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