Comparison of MRI (including SS SE-EPI and SPIO-enhanced MRI) and FDG-PET/CT for the detection of colorectal liver metastases

Coenegrachts, Kenneth; Geeter, Frank De; Beek, Léon ter; Walgraeve, Natascha; Bipat, Shandra; Stoker, Jaap; Rigauts, H

doi:10.1007/s00330-008-1163-y

Cited by 58 publications

(54 citation statements)

References 27 publications

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“…the entire body (12,(14)(15)(16)(17)(18). However, DWI at lower b-values may also be of use; several studies (19)(20)(21) have shown that this approach is very effective in suppressing liver vessels and improving sensitivity for the detection of liver lesions. Low b-value DWI in the liver exploits the difference in diffusion and perfusion between lesions (which generally have an impeded diffusion) and flowing blood (high diffusion and perfusion due to high flow and turbulence) (19)(20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

“…However, DWI at lower b-values may also be of use; several studies (19)(20)(21) have shown that this approach is very effective in suppressing liver vessels and improving sensitivity for the detection of liver lesions. Low b-value DWI in the liver exploits the difference in diffusion and perfusion between lesions (which generally have an impeded diffusion) and flowing blood (high diffusion and perfusion due to high flow and turbulence) (19)(20)(21)(22). Translating this concept to the small bowel in (strangulated) SBO may explain the findings of the present study; strangulated SBO is characterized by an incarcerated loop which lacks peristalsis, whereas peristalsis is still present in the prestenotic loop(s) (7,8).…”

Section: Discussionmentioning

confidence: 99%

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Low b‐value diffusion‐weighted imaging for diagnosing strangulated small bowel obstruction: A feasibility study

Takahara

Kwee

Sadahiro

et al. 2011

Magnetic Resonance Imaging

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Purpose: To assess the feasibility of low b-value diffusion-weighted imaging (DWI) for diagnosing strangulated small bowel obstruction (SBO). Apparent diffusion coefficients (ADCs) and signal preservation ratios (SPRs) were measured in the distal jejunum in the volunteers before and after butylscopolamine administration, and in the (strangulated) closed loop, near the obstructive site, and far from the obstructive site in the patients. Low b-value diffusion-weighted images in the patients were quantitatively evaluated for diagnosing strangulation.Results: In the volunteers, mean ADC (10 À3 mm 2 /s) and SPR (%) before butylscopolamine administration (18.3 6 5.9 and 41.4 6 11.5) were significantly different (P < 0.05) from those after butylscopolamine administration (6.4 6 3.6 and 73.7 6 12.9). In the patients, mean ADCs and SPRs among the strangulated closed loop (3.8 6 2.2 and 83.3 6 9.3), near the obstructive site (12.1 6 6.9 and 57.3 6 18.5), and far from the obstructive site (26.8 6 10.7 and 29.9 6 16.4) were significantly different (P < 0.05). Areas under the receiver operating characteristic curve for the diagnosis of strangulation varied between 0.937 and 1.000.Conclusion: Low b-value DWI is a feasible technique to distinguish the strangulated closed loop from nonstrangulated loops in SBO, and show promise for diagnosing strangulated SBO.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Low b‐value diffusion‐weighted imaging for diagnosing strangulated small bowel obstruction: A feasibility study

Takahara

Kwee

Sadahiro

et al. 2011

Magnetic Resonance Imaging

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“…Therefore, high-quality imaging of the liver and abdomen is needed shortly before surgery to avoid false-negative results. High-quality imaging means contrast-enhanced dynamic scanning using CT and/or MRI and, in the case of MRI, DWI besides the standard sequences [34,35]. For both CT and MRI these prerequisites for liver imaging are compatible with pancreatic imaging optimized for resectability assessment.…”

Section: Livermentioning

confidence: 99%

“…For both CT and MRI these prerequisites for liver imaging are compatible with pancreatic imaging optimized for resectability assessment. FDG-PET has the strength of a high specificity but a striking lack of sensitivity is reported regarding small liver metastases [35]. Therefore, FDG-PET is currently not the method of choice for resectability assessment of pancreatic cancer [13,36].…”

Section: Livermentioning

confidence: 99%

Radiologic Resectability Assessment in Pancreatic Cancer

Denecke

Grieser

Bahra

2013

Fortschr Röntgenstr

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Complete tumor resection is still the only potentially curative therapy option for patients with ductal adenocarcinoma of the pancreas. Surgical exploration is the gold standard for the determination of tumor resectability. Radiological resectability assessment is of great importance because many clearly unresectable cases can be identified preoperatively and it became essential for surgical planning. The evolving surgical and radiological techniques demand a continuous reappraisal of radiological criteria in resectability assessment. In the following, the criteria for resection planning are described along with surgical management and the role of radiology in some innovative surgical concepts is explained. Citation Format:

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“…For example, colorectal liver metastases, the presence of which can significantly alter clinical management, can be difficult to detect on PET/CT due to high background FDG uptake. Liver MRI including diffusion-weighted imaging (DWI) has already been shown to be more sensitive than PET/CT for hepatic metastases and consequently is routinely ordered in this setting to achieve accurate staging [2]. Likewise, while PET/CT is often obtained to evaluate for distant metastases from cervical cancer, pelvic MRI, with its high soft tissue contrast, provides superior accuracy for local staging [3].…”

Section: Introductionmentioning

confidence: 99%

Indeterminate Findings on Oncologic PET/CT: What Difference Does PET/MRI Make?

Fraum

Fowler

McConathy

et al. 2016

Nucl Med Mol Imaging

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Background Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[ 18 F]fluoro-D-glucose (FDG) has become the standard of care for the initial staging and subsequent treatment response assessment of many different malignancies. Despite this success, PET/CT is often supplemented by MRI to improve assessment of local tumor invasion and to facilitate detection of lesions in organs with high background FDG uptake. Consequently, PET/MRI has the potential to expand the clinical value of PET examinations by increasing reader certainty and reducing the need for subsequent imaging. This study evaluates the ability of FDG-PET/MRI to clarify findings initially deemed indeterminate on clinical FDG-PET/CT studies. Methods A total of 190 oncology patients underwent whole-body PET/CT, immediately followed by PET/MRI utilizing the same FDG administration. Each PET/CT was interpreted by our institution's nuclear medicine service as a standard-of-care clinical examination. Review of these PET/CT reports identified 31 patients (16 %) with indeterminate findings. Two readers evaluated all 31 PET/CT studies, followed by the corresponding PET/MRI studies. A consensus was reached for each case, and changes in interpretation directly resulting from PET/MRI review were recorded. Interpretations were then correlated with follow-up imaging, pathology results, and other diagnostic studies.Results In 18 of 31 cases with indeterminate findings on PET/CT, PET/MRI resulted in a more definitive interpretation by facilitating the differentiation of infection/inflammation from malignancy (15/18), the accurate localization of FDGavid lesions (2/18), and the characterization of incidental non-FDG-avid solid organ lesions (1/18). Explanations for improved reader certainty with PET/MRI included the superior soft tissue contrast of MRI and the ability to assess cellular density with diffusion-weighted imaging. The majority (12/18) of such cases had an appropriate standard of reference; in all 12 cases, the definitive PET/MRI interpretation proved correct. These 12 patients underwent six additional diagnostic studies to clarify the initial indeterminate PET/ CT findings. In the remaining 13 of 31 cases with indeterminate findings on both PET/CT and PET/MRI, common reasons for uncertainty included the inability to distinguish reactive from malignant lymphadenopathy (4/13) and local recurrence from treatment effect (2/13). Conclusions Indeterminate PET/CT findings can result in equivocal reads and additional diagnostic studies. PET/MRI may reduce the rate of indeterminate findings by facilitating better tumor staging, FDG activity localization, and lesion characterization. In our study, PET/ MRI resulted in more definitive imaging interpretations with high accuracy. PET/MRI also showed potential in reducing the number of additional diagnostic studies prompted by PET/CT findings. Our results suggest that whole-body PET/MRI provides certain diagnostic advantages over PET/CT, promotes more definitive imaging interpretations, and m...

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Comparison of MRI (including SS SE-EPI and SPIO-enhanced MRI) and FDG-PET/CT for the detection of colorectal liver metastases

Cited by 58 publications

References 27 publications

Low b‐value diffusion‐weighted imaging for diagnosing strangulated small bowel obstruction: A feasibility study

Low b‐value diffusion‐weighted imaging for diagnosing strangulated small bowel obstruction: A feasibility study

Radiologic Resectability Assessment in Pancreatic Cancer

Indeterminate Findings on Oncologic PET/CT: What Difference Does PET/MRI Make?

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