Comparison of nalbuphine and sufentanil for colonoscopy: A randomized controlled trial

Deng, Chaoyi; Xiao, Wang; Zhu, Qianmei; Kang, Yanming; Yang, Jinlin; Wang, Heng

doi:10.1371/journal.pone.0188901

Cited by 29 publications

(27 citation statements)

References 25 publications

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“…Jeleazcov, C et al found that PCA with hydromorphone offered satisfactory postoperative analgesic with respiratory insufficiency in 5% of the patients [11]. Correspondingly, Deng, C et al had reported that the risks of respiratory depression in patients undergoing colonoscopy was 33% by using sufentanil as a perioperative analgesia [30]. As mentioned above, hydromorphone also had a quicker therapeutic and better anti-inflammatory effect comparing with sufentanil.…”

Section: Discussionmentioning

confidence: 99%

Effects of patient-controlled analgesia with hydromorphone or sufentanil on postoperative pulmonary complications in patients undergoing thoracic surgery: a quasi-experimental study

et al. 2018

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ObjectiveTo compare the analgesic effects of patient-controlled intravenous analgesia (PCA) with hydromorphone and sufentanil after thoracic surgery on postoperative pulmonary complications (PPCs).MethodsA total of 142 patients who were scheduled for thoracic surgery were randomly allocated to receive PCA with hydromorphone (group A: experimental group): hydromorphone 0.2 mg/kg + dezocine 0.5 mg/kg + ramosetron 0.6 mg diluted with normal saline to 200 mL; or with sufentanil (group B: control group): sufentanil 3.0μg/kg + dezocine 0.5 mg/kg + ramosetron 0.6 mg diluted with normal saline to 200 mL. The parameters of intravenous analgesia pump were set as background dose 4 ml/h, PCA dose 1 mL, locking time 15 min. Pain NRS (numerical rating scale), Ramsay sedation score, nausea or vomiting score were evaluated at 0 h, 6 h, 12 h, 24 h, 48 h after operation. The cases of PPCs (atelectasis, pulmonary infection, respiratory failure), CRP (C-reaction protein) and inflammatory cells (white cell count and percentage of neutrophils) and blood gas analysis at 12 h after operation, length of ICU and postoperative stay were recorded for each patient.ResultsData of 136 patients were analyzed. Compared with group B (4[IQR:2,2]), the pain NRS in group A (2[IQR:4,4]) was significantly lower at 6 h after operation (P = 0.000). The CRP in group A (69.79 ± 32.13 mg/L) were lower than group B (76.76 ± 43.42 mg/L) after operation, but the difference was not significant (P = 0.427). No difference of nausea or vomiting was found between group A (7.3%) and group B (5.8%) postoperatively (P = 0.999). The PPCs were happened in 11 patients in group A (16.2%) and 22 patients in group B (32.4%) and the difference between two groups was significant (P = 0.027). Seven patients in group A (10.3%) and eighteen patients in group B (26.5%) had clinical evidence of pneumonia and the difference between two groups was significant (P = 0.014). The length of ICU and postoperative stay in group A were 2.73 h and 1.82 days less than group B respectively but the differences were not significant (P = 0.234, P = 0.186 respectively).ConclusionCompared with sufentanil, hydromorphone may provide better postoperative analgesic effect with less pulmonary complications for patients undergoing thoracic surgery, and it may accelerate patients’ rehabilitation.Trial registrationRandomized Controlled Trials ChiCTR1800014282c. Registered 3 January 2018.

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Section: Discussionmentioning

confidence: 99%

Effects of patient-controlled analgesia with hydromorphone or sufentanil on postoperative pulmonary complications in patients undergoing thoracic surgery: a quasi-experimental study

et al. 2018

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“…In the pilot experiment, we found patients with 2 mg•kg -1 of nalbuphine in 100 ml of saline for PICA had increased dizziness, and after the dosage of nalbuphine was reduced to 1 mg•kg -1 , the analgesic effect was equal, while dizziness was significantly reduced. Therefore, we used 1 mg•kg -1 of nalbuphine in 100 ml of saline for PICA for postoperative analgesia in Group N. However, despite using a lower dosage of nalbuphine for PCIA (the converted morphine dosage of Group N: the dosage of Group S=1:2), the VAS scores were lower in Group N than in Group S at postoperative 6 h, 12 h, and 24 h. This result is different from the study of Deng (10) and Gong(9) and similar to the study of Chen(14). This may be explained by a sex difference.…”

Section: Discussionmentioning

confidence: 76%

“…Nalbuphine can agitate the κ-opioid receptor to achieve an analgesic effect and antagonize the μopioid receptor to reduce the incidence of adverse reactions. It can be considered as a reasonable alternative to sufentanil, the μ-opioid receptor agonist, for varied surgical procedures (9,10,14). A study on the difference of the effects on the GI tract between them is still absent.…”

Section: Discussionmentioning

confidence: 99%

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Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynaecological malignancies: A randomized controlled trial

Chen

Tian

Zhang

et al. 2020

Clin Exp Pharma Physio

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Background The aim of this study was to compare the effects of nalbuphine and sufentanil on the gastrointestinal (GI) tract after laparoscopic surgery for gynecological malignancies. Methods A total of 100 patients aged between 18-70 years with American Society of Anesthesiologists (ASA) physical status I-II who scheduled for laparoscopic radical hysterectomy under general anaesthesia were enrolled. Patients were randomized to receive either sufentanil (Group S) or nalbuphine (Group N) to receive either sufentanil (Group S) or nalbuphine (Group N) in the intraoperative and postoperative periods. The time to the first passage of flatus, the time to the first defecation, the time to the toleration of diet, the serum gastrin and the length of hospital stay were compared between the groups. Postoperative pain by visual analogue scale (VAS), the number of PCA(patient-controlled analgesia)s, postoperative nausea and vomiting, and dizziness were compared between the groups. Results The time to the first passage of flatus(p =0.551), the time to the first defecation(p =0.310), the time to the toleration of diet(p =0.182), the serum gastrin(p =0.397), the number of postoperative nausea(p =0.920), vomit(p =0.334) and PCA events(p =0.167) and the length of hospital stay(p =0.482) were not significantly different between the two groups. VAS scores at postoperative 6 h(p=0.008), 12 h(p =0.002) and 24 h(p =0.013) were lower in Group N than in Group S. Conclusions Compared with sufentanil, nalbuphine was not associated with improved postoperative GI dysfunction after laparoscopic surgery for gynecological malignancies, but it was associated with reduced postoperative pain. Background Postoperative gastrointestinal (GI) dysfunction such as nausea, vomiting, inability to eat, deflation, prolonged bowel movements, and paralytic ileus are some of the most common complications after surgery, and the incidence is nearly 10-30%(1). The occurrence of postoperative GI dysfunction leads

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“…The primary aim of the study was to investigate the effects of doxapram on low SpO 2 . Low SpO 2 was considered significant when SpO 2 was < 90% [6]. A face mask covering the patient’s nose and mouth was applied when the SpO 2 < 90%.…”

Section: Methodsmentioning

confidence: 99%

Doxapram alleviates low SpO2 induced by the combination of propofol and fentanyl during painless gastrointestinal endoscopy

Lian

Wang

et al. 2019

BMC Anesthesiol

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BackgroundPainless gastrointestinal endoscopy under intravenous propofol anesthesia is widely applied in the clinical scenario. Despite the good sedation and elimination of anxiety that propofol provides, low SpO2 may also result. Doxapram is a respiratory stimulant with a short half-life. The primary aim of this study was to investigate the effects of doxapram on alleviating low SpO2 induced by the combination of propofol and fentanyl during painless gastrointestinal endoscopy.MethodsIn this prospective study, patients scheduled for painless gastrointestinal endoscopy were randomly assigned to group D or S with 55 patients per group. Initially, both groups received a combination of propofol and fentanyl. Patients in group D received 50 mg doxapram after propofol injection, while patients in group S received an equal volume of saline. Vital signs of the patients, propofol dose, examination duration, and incidences of low SpO2 were recorded.ResultsThere were no statistical differences in propofol consumption and examination duration between the two groups. Twenty-six patients in group S experienced low SpO2 versus 10 in group D (P = 0.001). Nineteen patients in group S underwent oxygenation with a face mask in contrast to 8 in group D (P = 0.015). Eighteen patients in group S were treated with jaw lifting compared to 5 in group D (P = 0.002). Four patients in group S underwent assisted respiration compared to 2 in group D (without statistical difference). The average oxygen saturation in group S was significantly lower than that in group D at 1, 2 and 3 min after propofol injection (P < 0.001, P = 0.001 and P = 0.020, respectively). There were no statistical differences in oxygen saturation at other time points. There were no statistical differences in MAP and HR (except for the time point of 1 min after the induction) between the two groups.ConclusionsLow dose of doxapram can effectively alleviate low SpO2 in painless gastrointestinal endoscopy with intravenous propofol, without affecting propofol consumption, examination duration, MAP, or HR.Trail registrationThe study was approved by the Institutional Ethics Committee of Clinical and New Technology of Wuxi People’s Hospital on 20th July, 2018 (KYLLH2018029) and registered in the Chinese Clinical Trial Register on 16th August, 2018 (ChiCTR1800017832).

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Comparison of nalbuphine and sufentanil for colonoscopy: A randomized controlled trial

Cited by 29 publications

References 25 publications

Effects of patient-controlled analgesia with hydromorphone or sufentanil on postoperative pulmonary complications in patients undergoing thoracic surgery: a quasi-experimental study

Effects of patient-controlled analgesia with hydromorphone or sufentanil on postoperative pulmonary complications in patients undergoing thoracic surgery: a quasi-experimental study

Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynaecological malignancies: A randomized controlled trial

Doxapram alleviates low SpO2 induced by the combination of propofol and fentanyl during painless gastrointestinal endoscopy

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