Comparison of Nanocomposite Film and Electrospun Nanocomposite Fibers Based on Poly (2-Hydroxy Ethyl Methacrylate) and Microcrystalline Cellulose as Anticancer Implants

Rao, Sowmya; Rajiv, Sheeja

doi:10.1080/03602559.2014.919654

Cited by 5 publications

(2 citation statements)

References 53 publications

(52 reference statements)

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“…The release of water-insoluble drugs from HpC films was examined by different study groups and the release profile was shown to be completed within approximately 10 h [71–73]. In another study regarding the release of paclitaxel (which is another member of taxane class, such as docetaxel, released from nanocomposite film) the initial release was observed within 7 h due to the rapid release of drugs from surface of the film [74]. Our studies proved that the DOC-encapsulated PCL-nanoparticle-loaded film formulation is quite suitable to provide a drug reservoir after surgical removal of glioma to avoid progression recurrence during the first 2 days.…”

Section: Resultsmentioning

confidence: 99%

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

Varan¹,

Bilensoy²

2017

Beilstein J. Nanotechnol.

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Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For this reason, the development of drug delivery systems is important to treat brain tumors and prevent tumor recurrence. The aim of this study was to develop core–shell polymeric nanoparticles with positive charge by employing a chitosan coating. Additionally, an implantable formulation for the chemotherapeutic nanoparticles was developed as a bioadhesive film to be applied at the tumor site following surgical operation for brain glioma treatment. To obtain positively charged, implantable nanoparticles, the effects of preparation technique, chitosan coating concentration and presence of surfactants were evaluated to obtain optimal nanoparticles with a diameter of less than 100 nm and a net positive surface charge to facilitate cellular internalization of drug-loaded nanoparticles. Hydroxypropyl cellulose films were prepared to incorporate these nanoparticle dispersions to complete the implantable drug delivery system. Results: The diameter of core–shell nanoparticles were in the range of 70–270 nm, depending on the preparation technique, polymer type and coating. Moreover, the chitosan coating significantly altered the surface charge of the nanoparticles to net positive values of +30 to +50 mV. The model drug docetaxel was successfully loaded into all particles, and the drug release rate from the nanoparticles was slowed down to 48 h by dispersing the nanoparticles in a hydroxypropyl cellulose film. Cell culture studies revealed that docetaxel-loaded nanoparticles cause higher cytotoxicity compared to the free docetaxel solution in DMSO. Conclusion: Docetaxel-loaded nanoparticles dispersed in a bioadhesive film were shown to be suitable for application of chemotherapeutics directly to the action site during surgical operation. The system was found to release chemotherapeutics for several days at the tumor site and neighboring tissue. This can be suggested to result in a more effective brain tumor treatment when compared to chemotherapeutics administered as an intravenous bolus infusion.

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Section: Resultsmentioning

confidence: 99%

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

Varan¹,

Bilensoy²

2017

Beilstein J. Nanotechnol.

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“…The composite coating reduced the biodegradation rate of the magnesium implants, known to promote bone healing and exhibit adequate mechanical strength during their biodegradation in the bone-healing process [101]. Another study on Mg-Ca-Zn biodegradable alloys used as orthopedic implants demonstrated high biocompatibility and excellent mechanical properties, making them suitable for small bones of the feet and hands, ankles, or small joints [102,103].…”

Section: • Biodegradable Medical Implantsmentioning

confidence: 99%

Advancements in Hybrid Cellulose-Based Films: Innovations and Applications in 2D Nano-Delivery Systems

Ramezani,

Stiharu,

van de Ven

et al. 2024

JFB

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This review paper delves into the realm of hybrid cellulose-based materials and their applications in 2D nano-delivery systems. Cellulose, recognized for its biocompatibility, versatility, and renewability, serves as the core matrix for these nanomaterials. The paper offers a comprehensive overview of the latest advancements in the creation, analysis, and application of these materials, emphasizing their significance in nanotechnology and biomedical domains. It further illuminates the integration of nanomaterials and advanced synthesis techniques that have significantly improved the mechanical, chemical, and biological properties of hybrid cellulose-based materials.

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Synthesis and characterization of biodegradable pHEMA-starch composites for immobilization of L-asparaginase

2015

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Comparison of Nanocomposite Film and Electrospun Nanocomposite Fibers Based on Poly (2-Hydroxy Ethyl Methacrylate) and Microcrystalline Cellulose as Anticancer Implants

Cited by 5 publications

References 53 publications

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

Advancements in Hybrid Cellulose-Based Films: Innovations and Applications in 2D Nano-Delivery Systems

Synthesis and characterization of biodegradable pHEMA-starch composites for immobilization of L-asparaginase

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