Comparison of neutrophils/lymphocytes ratio between idiopathic epiretinal membrane and macular hole

The Diagnostic Value of Neutrophil to Lymphocyte Ratio as an Effective Biomarker for Eye Disorders: A Meta-Analysis

“…Concerning document language, 31 studies were in English [ 3 – 31 , 37 , 38 ], and one study in Turkish [ 35 ]. In terms of study design, there were 11 prospective [ 4 – 6 , 11 , 13 , 16 , 21 , 24 , 27 , 28 , 30 ] and 21 retrospective studies [ 3 , 7 – 10 , 12 , 14 , 15 , 17 – 20 , 22 , 23 , 25 , 26 , 29 , 31 , 35 , 37 , 38 ]. Overall, 3242 healthy controls and 3378 patients with eye diseases were enrolled in the selected studies.…”

“…The general characteristics of the selected studies and their quality score are presented in Table 1 . We found six studies on KC [ 5 , 11 , 13 , 15 , 23 , 27 ], six studies on pterygium [ 12 , 16 , 17 , 19 , 22 , 35 ], four studies on DED [ 6 , 21 , 24 , 28 ], and four studies on iERM [ 7 , 8 , 10 , 30 ]. Also, the association between NLR and glaucoma was investigated in 12 studies [ 3 , 4 , 9 , 14 , 18 , 20 , 25 , 26 , 29 , 31 , 37 , 38 ], of which four were conducted among East Asian patients [ 20 , 29 , 31 , 38 ] and eight among Caucasian patients [ 3 , 4 , 9 , 14 , 18 , 25 , 26 , 37 ].…”

“…Of 32 studies, 23 studies [ 4 , 6 , 7 , 10 – 13 , 15 – 17 , 19 , 21 – 24 , 26 – 30 , 35 , 38 ] excluded the patients who were smoking, using alcohol, or receiving medications that could affect the ocular surface of the eye and blood parameters. These include systemic or ocular medications including topical steroids, anti-inflammatory medications, iron preparations, vitamins, and chemotherapeutic agents.…”

“…In four studies [ 7 , 8 , 10 , 30 ], iERM patients' NLR levels were compared with those of healthy controls including 178 patients and 176 controls. Compared to healthy individuals, patients with iERM had significantly higher levels of NLR (SMD =0.14; 95% CI =0.01-0.26, P < 0.001) ( Figure 6 ).…”

“…It may cause decreased visual acuity, metamorphopsia, monocular diplopia, macropsia, and micropsia [ 40 ]. Several researchers have reported that NLR levels were higher in iERM patients than healthy controls [ 7 , 8 , 10 , 30 ].…”