Comparison of nicotinamide adenine dinucleotide phosphate-induced immune responses against biotrophic and necrotrophic pathogens in <i>Arabidopsis thaliana</i>

Wang, Chenggang; Zhang, Xudong; Mou, Zhonglin

doi:10.1080/15592324.2016.1169358

Cited by 10 publications

(4 citation statements)

References 14 publications

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“…Many studies have correlated the phenomenon of PN accumulation and PR gene expression. Extracellular application of pyridine nucleotides induce plant resistance to pathogen (Zhang and Mou, 2009; Alferez et al, 2018; Wang et al, 2016; Sidiq et al, 2021). (Ge et al, 2007; Reducing the level of pyridine nucleotides through genetic manipulation results in the compromisation of SA pathway activation and pathogen resistance (Li et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Capsicum chinenseJacq. derived glutaredoxin (CcGRXS12) alters phytohormonal pathways and redox status of the cells to confer resistance against pepper mild mottle virus (PMMoV-I)

R.M.¹,

S.V²,

Sun³

et al. 2023

Preprint

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Glutaredoxins (Grxs) are small, ubiquitous, multi-functional proteins present in different compartments of plant cells. A chloroplast targeted class I GRX (CcGRXS12) gene was isolated from Capsicum chinense during the pepper mild mottle virus (PMMoV) infection. Functional characterization of the gene was performed in N. benthamiana transgenic plants transformed with native C. chinense GRX (Nb:GRX), GRX-fused with GFP (Nb:GRX-GFP) and GRX truncated for the chloroplast targeting sequences but fused with GFP (Nb:Δ2MGRX-GFP). Over-expression of CcGRXS12 inhibits the PMMoV-I accumulation at late stage of infection and is accompanied with the activation of SA- pathway pathogenesis related (PR) transcripts, and suppression of JA/ET- pathway transcripts. Further the reduced accumulation of auxin-induced Glutathione-S-Transferase (pCNT103) in CcGRXS12 over expressing lines indicates that the protein could able to protect the plants from the oxidative stress caused by the virus. PMMoV-I infection increases accumulation of pyridine nucleotides (PNs) mainly due to the reduced form of PNs (NAD(P)H) and it was higher in Nb:GRX-GFP lines compared to other lines where infection is limited. Apart from biotic stress, CcGRXS12 protects the plants from abiotic stress conditions caused by H2O2 and herbicide paraquat. CcGRXS12 exhibits GSH-disulphide oxidoreductase activity in vitro however devoid of complementary Fe-S cluster assembly mechanism in yeast.

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Section: Discussionmentioning

confidence: 99%

Capsicum chinenseJacq. derived glutaredoxin (CcGRXS12) alters phytohormonal pathways and redox status of the cells to confer resistance against pepper mild mottle virus (PMMoV-I)

R.M.¹,

S.V²,

Sun³

et al. 2023

Preprint

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“…Besides defense gene activation, the metabolite also controls processes required for cell wall repair (cf. [ 272 , 305 , 306 ]).…”

Section: Extracellular Pyridine Nucleotides Inform Neighboring Cellsmentioning

confidence: 99%

Signals and Their Perception for Remodelling, Adjustment and Repair of the Plant Cell Wall

Oelmüller

Tseng

Gandhi

2023

IJMS

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The integrity of the cell wall is important for plant cells. Mechanical or chemical distortions, tension, pH changes in the apoplast, disturbance of the ion homeostasis, leakage of cell compounds into the apoplastic space or breakdown of cell wall polysaccharides activate cellular responses which often occur via plasma membrane-localized receptors. Breakdown products of the cell wall polysaccharides function as damage-associated molecular patterns and derive from cellulose (cello-oligomers), hemicelluloses (mainly xyloglucans and mixed-linkage glucans as well as glucuronoarabinoglucans in Poaceae) and pectins (oligogalacturonides). In addition, several types of channels participate in mechanosensing and convert physical into chemical signals. To establish a proper response, the cell has to integrate information about apoplastic alterations and disturbance of its wall with cell-internal programs which require modifications in the wall architecture due to growth, differentiation or cell division. We summarize recent progress in pattern recognition receptors for plant-derived oligosaccharides, with a focus on malectin domain-containing receptor kinases and their crosstalk with other perception systems and intracellular signaling events.

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“…Because NAD + levels influence numerous cellular processes, the consumption of NAD + by plant TIRs during immunity could impact myriad cellular responses. For instance, extracellular NAD + (eNAD + ) is a potent immunostimulatory signal and reducing NAD + levels compromises disease resistance; conversely, eNAD + application can bolster immunity (Zhang and Mou, 2012;Wang et al, 2016;Mou, 2017;Alferez et al, 2018). Likewise, the AvrRxo1 and RipN, virulence-promoting effectors of plant pathogens, can modulate host NAD + homeostasis and defense responses (Schuebel et al, 2016;Shidore et al, 2017;Sun et al, 2019).…”

Section: How Might Plant Tir-nadases Transmit Immune Signals?mentioning

confidence: 99%

Enzymatic Functions for Toll/Interleukin-1 Receptor Domain Proteins in the Plant Immune System

Bayless

Nishimura

2020

Front. Genet.

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Rationally engineered improvements to crop plants will be needed to keep pace with increasing demands placed on agricultural systems by population growth and climate change. Engineering of plant immune systems provides an opportunity to increase yields by limiting losses to pathogens. Intracellular immune receptors are commonly used as agricultural disease resistance traits. Despite their importance, how intracellular immune receptors confer disease resistance is still unknown. One major class of immune receptors in dicots contains a Toll/Interleukin-1 Receptor (TIR) domain. The mechanisms of TIR-containing proteins during plant immunity have remained elusive. The TIR domain is an ancient module found in archaeal, bacterial and eukaryotic proteins. In animals, TIR domains serve a structural role by generating innate immune signaling complexes. The unusual animal TIR-protein, SARM1, was recently discovered to function instead as an enzyme that depletes cellular NAD + (nicotinamide adenine dinucleotide) to trigger axonal cell death. Two recent reports have found that plant TIR proteins also have the ability to cleave NAD +. This presents a new paradigm from which to consider how plant TIR immune receptors function. Here, we will review recent reports of the structure and function of TIR-domain containing proteins. Intriguingly, it appears that TIR proteins in all kingdoms may use similar enzymatic mechanisms in a variety of cell death and immune pathways. We will also discuss TIR structure-function hypotheses in light of the recent publication of the ZAR1 resistosome structure. Finally, we will explore the evolutionary context of plant TIR-containing proteins and their downstream signaling components across phylogenies and the functional implications of these findings.

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Comparison of nicotinamide adenine dinucleotide phosphate-induced immune responses against biotrophic and necrotrophic pathogens in Arabidopsis thaliana

Cited by 10 publications

References 14 publications

Capsicum chinenseJacq. derived glutaredoxin (CcGRXS12) alters phytohormonal pathways and redox status of the cells to confer resistance against pepper mild mottle virus (PMMoV-I)

Capsicum chinenseJacq. derived glutaredoxin (CcGRXS12) alters phytohormonal pathways and redox status of the cells to confer resistance against pepper mild mottle virus (PMMoV-I)

Signals and Their Perception for Remodelling, Adjustment and Repair of the Plant Cell Wall

Enzymatic Functions for Toll/Interleukin-1 Receptor Domain Proteins in the Plant Immune System

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