An original method for time delay estimation is presented. It is based on changing input signals into cumulative ones, followed by determination of inflection points of cumulative curves, and estimation of time delay as time difference of these points’ occurrences. To determine the inflection points, a suitable algorithm is proposed. The preliminary results show that the proposed method is sufficiently efficient, especially in the case of flow measurements based on tomography technique when the cross-correlation function of the signals has no evident peak. This method has no limitations on its application for different types of input signals.