Comparison of Nutrient Intake and Diet Quality Between Hyperuricemia Subjects and Controls in Korea

Abstract

Hyperuricemia is associated with metabolic syndrome as well as gout, and the prevalence of hyperuricemia is increasing in Korea. This study aimed to compare the nutrient intake and diet quality between hyperuricemia subjects and controls. Of the 28,589 people who participated in a health examination between 2008 and 2011, 9,010 subjects were selected whose 3-day food records were available. Clinical and laboratory data were collected from electronic medical records. Diet quality was evaluated using the food habit score (FHS), nutrient adequacy ratio (NAR), and mean adequacy ratio (MAR). The prevalence of hyperuricemia was 13.8% (27.1%, men; 5.2%, women). Body mass index, waist circumference, triglycerides, total cholesterol, and low-density lipoprotein cholesterol were significantly higher (p < 0.0001), while high-density cholesterol (p < 0.001) was significantly lower in the hyperuricemia subjects than in the controls. The hyperuricemia subjects had a lower intake of vitamin A (p < 0.004), vitamin C, folate, fiber, and calcium than the controls (p < 0.0001). Intake of vegetables and dairy products was significantly lower, whereas alcohol intake was significantly higher in the hyperuricemia subjects than in the controls ( p < 0.0001). The FHS (p < 0.0001), MAR (p < 0.0001), and NARs for vitamin A (p = 0.01), vitamin B2, vitamin C, folate, and calcium (p < 0.0001) were significantly lower in the hyperuricemia subjects than in the controls. In conclusion, the hyperuricemia subjects reported poorer diet quality than the controls, including higher alcohol intake and lower vegetable and dairy product intake.

Gout

“…Prospective data on incident gout showed that males in the highest quintile of dairy intake had a RR of 0.56 (95 % CI, 0.42-0.74) when compared to the lowest quintile (76). This inverse correlation of dairy and uric acid has been observed in the Scottish and Korean populations as well (94, 96). A randomized controlled trial (RCT) found that milk consumption lead to an acute 10% decrease in serum uric acid (p<0.0001) and an increase in FEUA (97).…”

New association of bone morphogenetic protein 4 concentrations with fat distribution in obesity and Exenatide intervention on it

“…Hyperuricemia was defined as serum UA ≥ 7 mg/dl (≥417 umol/L) in males, and ≥ 6 mg/dl (≥357 umol/L) in females [15]. Mild increased TSH was defined in this study as a TSH level ranged from 2.5 to 5.5 mU/l and a normal free-thyroxine level [16, 17].…”

L’effet de la prise de vitamine C sur le risque d’hyperuricémie et sur l’uricémie chez les Coréens. Cohorte multi-rurale

“…Le fait que la vitamine C réduise l'uricémie a été prouvée sur deux précédentes populations, la cohorte prospective HPFS [8] et une étude transversale [17]. Cependant, cet effet a été inconnu si l'on considérait les deux sexes à part.…”