Comparison of Ocular Hypotensive Effect and Safety of Brinzolamide and Timolol Added to Latanoprost

Abstract

Brinzolamide and timolol added to latanoprost have similar ocular hypotensive effects and safety in primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension.

Systematic Review of Intraocular Pressure-Lowering Effects of Adjunctive Medications Added to Latanoprost

“…Of these, 65 had to be excluded for reasons summarized in table 2 . After the completed selection process, 9 randomized clinical trials which met our inclusion criteria were included in the systematic review [15][16][17][18][19][20][21][22][23] .…”

Efficacy of Single Glaucoma Drug in Combined Timolol XE, Latanoprost and Brinzolamide Therapy: A Discontinuation Study

“…Several investigations have compared hypotensive effects of latanoprost, timolol, and carbonic anhydrase inhibitors as adjunctive therapy. [20][21][22][23][24][25][26][27] Latanoprost produced a significantly greater reduction compared with b-blockers and carbonic anhydrase inhibitors in all available data except one, in which Alm et al showed that adding latanoprost to the eyes treated with timolol provide a reduction of 2.6 -1.1 mmHg (13%), whereas adding timolol to the eyes receiving latanoprost resulted in a reduction of 2.6 -2.2 mmHg (14%). 20,21 There were several studies comparing the efficacy of b-blockers and topical carbonic anhydrase inhibitors in multiple drug treatment.…”

Timolol versus brinzolamide added to travoprost in glaucoma or ocular hypertension

“…Miura et al [12] investigated the ocular hypotensive effect of brinzolamide and timolol when added to latanoprost in 32 patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension, over a 12-week period. The results of their study showed a The table shows the number of adverse events (N) registered in each of the study groups, as well as the number (n) and percentage (%) of patients reporting them within these groups.…”