Comparison of olive leaf, olive oil, palm oil, and omega-3 oil in acute kidney injury induced by sepsis in rats

Ramos, Maria Fátima de Paula; Oliveira, Olvania Basso; Barros, Alceni do Carmo Morais Monteiro de; Razvickas, Clara Versolato; Pessoa, Edson de Andrade; Silva, Rinaldo Florêncio da; Pereira, Ana Maria Soares; Convento, Márcia Bastos; Borges, Fernanda Teixeira; Schor, Nestor

doi:10.7717/peerj.7219

Cited by 6 publications

(3 citation statements)

References 59 publications

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“…Overall, this work strengthens the already existing data on the beneficial effects of olive leaf extract intake as an anti-oxidant, anti-bacterial and anti-inflammatory agent [ 14 , 60 , 61 , 62 ], also in upper respiratory illnesses [ 63 ]. In addition, it suggests its use to modulate the cytokine storm occurring during several forms of viral infections, especially in aged individuals.…”

Section: Discussionsupporting

confidence: 85%

Anti-Inflammatory Effects of Olive Leaf Extract and Its Bioactive Compounds Oleacin and Oleuropein-Aglycone on Senescent Endothelial and Small Airway Epithelial Cells

et al. 2023

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Olive tree by-products have been deeply studied as an invaluable source of bioactive compounds. Several in vitro and in vivo studies showed that olive leaf extract (OLE) has anti-inflammatory and antioxidant properties. Here, we wanted to assess the valuable benefits of two less-studied OLE components—3,4-DHPEA-EDA (Oleacin, OC) and 3,4-DHPEA-EA (Oleuropein-Aglycone, OA)—directly purified from OLE using a cost-effective and environmentally sustainable method, in line with the principles of circular economy. OLE, OC and OA were then tested in human cellular models involved in acute and chronic inflammation and in the pathogenesis of viral infections, i.e., lipopolysaccharide (LPS)-treated monocyte/macrophages (THP-1) and endothelial cells (HUVECs), senescent HUVECs and Poly(I:C)-treated small airway epithelial cells (hSAECs). Results showed that OC and OA are efficient in ameliorating almost all of the pro-inflammatory readouts (IL-1β, TNF-α, IL-8, ICAM, VCAM) and reducing the release of IL-6 in all the cellular models. In hSAECs, they also modulate the expression of SOD2, NF-kB and also ACE2 and TMPRSS2, whose expression is required for SARS-CoV-2 virus entry. Overall, these data suggest the usefulness of OLE, OC and OA in controlling or preventing inflammatory responses, in particular those associated with viral respiratory infections and aging.

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Section: Discussionsupporting

confidence: 85%

Anti-Inflammatory Effects of Olive Leaf Extract and Its Bioactive Compounds Oleacin and Oleuropein-Aglycone on Senescent Endothelial and Small Airway Epithelial Cells

et al. 2023

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“…In this paper, we report for the first time the beneficial effects of an olive leaf extract rich in flavonoids and secoiridoids, administered at a dose of 100 mg/kg/day for three weeks, on sarcopenia and insulin sensitivity in skeletal muscle and adipose tissue of aged rats. This dose is considerably lower than the one used by other authors in an experimental model of aging in rats (100 mg/kg vs 500 and 1000 mg/kg) [ 41 ] and was selected based on its positive effects for the alleviation of several inflammatory conditions in rodents such as sepsis [ 42 ], arthritis [ 43 ] or gastritis [ 44 ]. In addition, the same dose of OLE is reported to reduce the LDL/HDL ratio [ 45 ] and exert protective effects in experimental models of cerebral ischemia [ 45 , 46 ], as well as to prevent type-2 diabetes in rats by decreasing the total antioxidant capacity in the plasma and the expression superoxide dismutase in the liver [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Olive Leaf Extract Supplementation to Old Wistar Rats Attenuates Aging-Induced Sarcopenia and Increases Insulin Sensitivity in Adipose Tissue and Skeletal Muscle

et al. 2021

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Aging is associated with increased visceral adiposity and a decrease in the amount of brown adipose tissue and muscle mass, known as sarcopenia, which results in the development of metabolic alterations such as insulin resistance. In this study, we aimed to analyze whether 3-week supplementation with a phenolic-rich olive leaf extract (OLE) to 24 months-old male Wistar rats orally (100 mg/kg) attenuated the aging-induced alterations in body composition and insulin resistance. OLE treatment increased brown adipose tissue and attenuated the aging-induced decrease in protein content and gastrocnemius weight. Treatment with OLE prevented the aging-induced increase in the expression of PPAR-γ in visceral and brown adipose tissues, while it significantly increased the expression of PPAR-α in the gastrocnemius of old rats and reduced various markers related to sarcopenia such as myostatin, HDAC-4, myogenin and MyoD. OLE supplementation increased insulin sensitivity in explants of gastrocnemius and epididymal visceral adipose tissue from aged rats through a greater activation of the PI3K/Akt pathway, probably through the attenuation of inflammation in both tissues. In conclusion, supplementation with OLE prevents the loss of muscle mass associated with aging and exerts anti-inflammatory and insulin-sensitizing effects on adipose tissue and skeletal muscle.

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“…Polyunsaturated Omega 3 fatty acids (ω3-PUFAs) are essential fatty acids with anti-inflammatory effects that are reported to improve cellular immune function in patients with sepsis ( 45 , 46 ) and to reduce sepsis-induced mortality ( 47 ), possibly through increased production of pro-resolvin molecules like maresins, resolvins and protectins ( 48 , 49 ). A recent study has reported that, in addition to ω3-PUFAs, olive tree derived products such as extra virgin olive oil and olive leaf extracts are also beneficial to prevent sepsis-induced inflammation and to increase the survival rate ( 50 ). Although there is some evidence about the therapeutic effect of these products, very little is known about their possible preventive effects reducing severe condition in septic patients.…”

Section: Introductionmentioning

confidence: 99%

A Nutraceutical Product Based on a Mixture of Algae and Extra Virgin Olive Oils and Olive Leaf Extract Attenuates Sepsis-Induced Cardiovascular and Muscle Alterations in Rats

et al. 2022

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Nutraceuticals are products of natural origin widely used for the treatment and/or prevention of some chronic diseases that are highly prevalent in Western countries, such as obesity or type II diabetes, among others. However, its possible use in the prevention of acute diseases that can put life at risk has been poorly studied. Sepsis is an acute condition that causes cardiovascular and skeletal muscle damage due to a systemic inflammatory state. The aim of this work was to evaluate the possible beneficial effect of a new nutraceutical based on a mixture of algae oil (AO) and extra virgin olive oil (EVOO) supplemented with an olive leaf extract (OLE) in the prevention of cardiovascular alterations and skeletal muscle disorders induced by sepsis in rats. For this purpose, male Wistar rats were treated with the nutraceutical or with water p.o. for 3 weeks and after the treatment they were injected with 1mg/kg LPS twice (12 and 4 h before sacrifice). Pretreatment with the nutraceutical prevented the LPS-induced decrease in cardiac contractility before and after the hearts were subjected to ischemia-reperfusion. At the vascular level, supplementation with the nutraceutical did not prevent hypotension in septic animals, but it attenuated endothelial dysfunction and the increased response of aortic rings to the vasoconstrictors norepinephrine and angiotensin-II induced by LPS. The beneficial effects on cardiovascular function were associated with an increased expression of the antioxidant enzymes SOD-1 and GSR in cardiac tissue and SOD-1 and Alox-5 in arterial tissue. In skeletal muscle, nutraceutical pretreatment prevented LPS-induced muscle proteolysis and autophagy and significantly increased protein synthesis as demonstrated by decreased expression of MURF-1, atrogin-1, LC3b and increased MCH-I and MCH -IIa in gastrocnemius muscle. These effects were associated with a decrease in the expression of TNFα, HDAC4 and myogenin. In conclusion, treatment with a new nutraceutical based on a mixture of AO and EVOO supplemented with OLE is useful to prevent cardiovascular and muscular changes induced by sepsis in rats. Thus, supplementation with this nutraceutical may constitute an interesting strategy to reduce the severity and mortality risk in septic patients.

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Comparison of olive leaf, olive oil, palm oil, and omega-3 oil in acute kidney injury induced by sepsis in rats

Cited by 6 publications

References 59 publications

Anti-Inflammatory Effects of Olive Leaf Extract and Its Bioactive Compounds Oleacin and Oleuropein-Aglycone on Senescent Endothelial and Small Airway Epithelial Cells

Anti-Inflammatory Effects of Olive Leaf Extract and Its Bioactive Compounds Oleacin and Oleuropein-Aglycone on Senescent Endothelial and Small Airway Epithelial Cells

Olive Leaf Extract Supplementation to Old Wistar Rats Attenuates Aging-Induced Sarcopenia and Increases Insulin Sensitivity in Adipose Tissue and Skeletal Muscle

A Nutraceutical Product Based on a Mixture of Algae and Extra Virgin Olive Oils and Olive Leaf Extract Attenuates Sepsis-Induced Cardiovascular and Muscle Alterations in Rats

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