Comparison of oral human papilloma virus detection methods among Hispanic adults

Castañeda‐Avila, Maira A.; Pérez, Cynthia M.; Vivaldi-Oliver, José; Díaz‐Toro, Elba C.; Ortiz, Ana P.

doi:10.1002/cre2.522

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Thus, the collection method may be an important source of variation in prevalence studies. [29][30][31] As for risk factors, frequenting gay meeting places and living in a large city (for hrHPV) were associated with HPV detection. HPV detection was also significantly associated with intercurrent anal CT/ NG infection.…”

Section: Discussionmentioning

confidence: 99%

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Anal and oropharyngeal HPV distribution in HIV‐negative multipartner MSM using self‐sampling kits for HIV and sexually transmitted infection screening

Prétet,

Baraquin,

Barret

et al. 2023

Journal of Medical Virology

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Men who have sex with men (MSM) are at high risk of sexually transmitted infections, among which HPV infections are particularly prominent. We took advantage of the MémoDépistages study to evaluate HPV distribution at anal and oropharyngeal sites in HIV‐negative multipartner MSM. HPV DNA was detected in 82% (n = 344) of anal and 11% (n = 45) of oropharyngeal self‐collected samples taken from 421 participants. Multiple HPV types were detected in 70% of anal samples, and single HPV types in 91% of oropharyngeal samples. HPV16 was the most frequent type detected in the anus, followed by HPV6, HPV51, and HPV52. HPV6, HPV16, and HPV11 were the most prevalent types in the oropharynx. HPV targeted by the nonavalent vaccine was detected in 71% and 50% of HPV‐positive anal and oropharyngeal samples, respectively. The main risk factor associated with HPV detection was frequenting gay meeting places, living in large cities, and having an anal Chlamydia trachomatis/Neisseria gonorrhoeae infection. In this cohort of highly sexually active MSM, HPV detection was highly frequent and rendered them at high risk of precancerous and cancerous lesions. Universal vaccination against HPV before sexual debut is an important public health strategy to prevent HPV‐associated cancers in this highly vulnerable population of HIV‐negative MSM.

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Section: Discussionmentioning

confidence: 99%

“…Swabbing the oropharynx is also more difficult to perform than swabbing the oral cavity, particularly in self‐sampling. Thus, the collection method may be an important source of variation in prevalence studies 29–31 …”

Section: Discussionmentioning

confidence: 99%

Anal and oropharyngeal HPV distribution in HIV‐negative multipartner MSM using self‐sampling kits for HIV and sexually transmitted infection screening

Prétet,

Baraquin,

Barret

et al. 2023

Journal of Medical Virology

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Comparison of oral human papilloma virus detection methods among Hispanic adults

Castañeda‐Avila

Pérez

Vivaldi-Oliver

et al. 2021

Clinical & Exp Dental Res

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Objectives: Oral human papilloma virus (HPV) infection is associated with nearly three-quarters of all oropharyngeal cancers in the United States. Research also suggests its association with periodontal disease. There are limited studies evaluating differences in HPV detection methods; however, oral rinse is considered the most sensitive detection method. We compared HPV detection by self-collected oral rinse versus self-collected cytobrush and assessed whether the strength of association between periodontitis and HPV is modified by the collection method.Materials and Methods: Data from a cross-sectional study of Hispanic adults in Puerto Rico (n = 346) who provided oral rinse and cytobrush samples for oral HPV detection and were clinically evaluated for periodontitis. The agreement between the oral mouthwash and cytobrush methods was assessed using the Kappa (κ) statistic. Logistic regression models were used to determine if the association between HPV infection and other risk factors varied by oral sample collection method.Results: HPV prevalence was slightly higher using cytobrush than oral rinse (5.8% vs. 4.3%). The sensitivity of cytobrush to detect oral HPV was 64.7%, and the specificity was 97.4%. We observed a κ of 0.61 (95% confidence interval [CI]: 0.45-0.78), indicative of fair to good agreement between the two collection methods. The association between oral HPV infection and periodontitis severity was stronger when using the oral rinse collection method (odds ratio [OR] = 3.23, 95% CI:1.06-9.84); the association was not statistically significant for cytobrush (OR = 1.96, 95% CI: 0.68-5.65).Conclusions: These findings support the significance of choosing the most suitable collection method in oral HPV-related studies. Selecting the most appropriate collection method is an essential criterion in oral HPV-related studies.

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Human Papilloma Virus (HPV) Detection in Oral Rinse vs. Oral Sponge: A Preliminary Accuracy Report in Oral Cancer Patients

Panzarella,

Buttà,

Buttacavoli

et al. 2024

Cancers

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Background/Objectives: Human Papillomavirus (HPV) is a significant etiological factor in the development of oropharyngeal carcinogenesis. The detection of HPV in oral squamous cell carcinoma (OSCC) could be also crucial for diagnosis, prognosis, and treatment planning. This study compares the efficacy and accuracy of two non-invasive sampling methods, oral rinse, and oral sponge, in detecting HPV DNA in patients with OSCC. Methods: Twenty-six patients with histologically confirmed OSCCs were recruited (M/F = 15/11; mean age 68.6). From each patient, two self-collected oral specimens, in the form of an oral rinse and a salivary sponge (i.e., LolliSponge), were collected, and subsequently processed, utilizing INNO-LiPA HPV Genotyping Extra II for HPV DNA detection; Results: Oral sponge detection showed high specificity (100%), sensitivity (85.7%), and accuracy (96.2%) compared to the oral rinse sampling, also demonstrating an area AUC for its diagnostic performance significantly greater than 0.5 (0.93 vs. 0.5, p < 0.0001). Conclusions: This study supports that oral sponge sampling offers valuable non-invasive alternatives for HPV detection in patients with OSCC, with the potentiality to facilitate saliva sampling in patients that may exhibit functional deficit due to OSCC. Further research is recommended to validate these findings in larger cohorts and to explore the integration of these methods into routine clinical practice for the management of HPV-related OSCC.

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Comparison of oral human papilloma virus detection methods among Hispanic adults

Cited by 3 publications

References 26 publications

Anal and oropharyngeal HPV distribution in HIV‐negative multipartner MSM using self‐sampling kits for HIV and sexually transmitted infection screening

Anal and oropharyngeal HPV distribution in HIV‐negative multipartner MSM using self‐sampling kits for HIV and sexually transmitted infection screening

Comparison of oral human papilloma virus detection methods among Hispanic adults

Human Papilloma Virus (HPV) Detection in Oral Rinse vs. Oral Sponge: A Preliminary Accuracy Report in Oral Cancer Patients

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