Comparison of oral ketamine and oral midazolam as sedative agents in pediatric dentistry

Sg, Damle; Gandhi, Mauli K.; Laheri, Vandana

doi:10.4103/0970-4388.43186

Cited by 32 publications

(3 citation statements)

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“…In a study by Damle et al comparing oral ketamine and oral midazolam as sedative agents in pediatric dentistry in India, the sedative drugs used as premedication for the study were oral ketamine 5 mg/kg and oral midazolam 0.5 mg/kg [15]. The oral route was chosen in this study as it was the most acceptable and familiar mode of drug administration [16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Use of oral ketamine for analgesia during reduction/manipulation of fracture/dislocation in the Emergency Room: An initial experience in a low-resource setting

Ogboli-Nwasor¹,

Amaefule²,

Audu³

2014

PST

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Section: Discussionmentioning

confidence: 99%

Use of oral ketamine for analgesia during reduction/manipulation of fracture/dislocation in the Emergency Room: An initial experience in a low-resource setting

Ogboli-Nwasor¹,

Amaefule²,

Audu³

2014

PST

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“…[7] Various preclinical and clinical studies have reported that clonidine produces antinociception regardless of the route of administration (central or peripheral). [8] Topical administration of clonidine elicits antinociception by blocking the emerging pain signals at peripheral terminals through alpha 2 adrenoceptors without producing the undesirable central side effect observed after systemic administration. [9] The present study was conducted to assess the role of betamethasone gel applied over the endotracheal tube cuff for attenuation of POST in patients undergoing surgeries under GA with endotracheal intubation and compare it with ketamine nebulization.…”

Section: Discussionmentioning

confidence: 99%

Betamethasone Versus Ketamine for Attenuation of POST in Patients Undergoing Surgeries Under GA with Endotracheal Intubation- A Clinical Study

Sankardevar¹,

Arjun²,

Hegde³

2020

AAN

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Background: Postoperative sore throat is one of the most common complications after endotracheal intubation. The present study was conducted to assess the role of betamethasone gel applied over the endotracheal tube cuff for attenuation of POST in patients undergoing surgeries under GA with endotracheal intubation and compare it with ketamine nebulization. Subjects and Methods : This is a randomized controlled prospective study conducted in 90 patients of either sex between 18-70 years of age divided into three groups. Group I patients received ketamine 50 mg, group II received 3 ml of water soluble 0.05% betamethasone gel, group III received 3 ml of water soluble 2% lignocaine. POST was graded on a four-point scale (0–3); 0 = no sore throat; 1 = mild sore throat (complains of sore throat only on questioning); 2 = moderate sore throat (complains of sore throat on his/her own); 3 = severe sore throat (change of voice or hoarseness, associated with severe throat pain). Results: The mean duration of surgery in group I was 128.5 minutes, in group II was 131 minutes and in group III was 134.5 minutes. There were 6 (20%), 7 (23.3) and 14 (46.6%) cases in group I, II and III respectively. The difference was significant (P< 0.05). At 0 hour there were 3 cases in group I, II and 10 in group III, at 2 hours was 3, 5 and 12 in group I, II and III respectively, at 6 hours was 5,4 and 14 cases in group I, II and III respectively, at 12 hours was 3, 3 and 12 cases in group I, II and III respectively and at 24 hours was 2, 2 and 12 cases in group I, II and III respectively. Conclusion: Authors found that POST can be equally managed with nebulisation with ketamine preoperatively and application of betamethasone gel over endotracheal tube cuff.

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“…Like midazolam, ketamine has the ability to promote anterograde amnesia 25 . In addition to amnesia, ketamine is expected to reduce pain perception and improve a child's comfort level during invasive procedures 26,27 .…”

Section: Discussionmentioning

confidence: 99%

Moderate sedation helps improve future behavior in pediatric dental patients – a prospective study

et al. 2016

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There is little evidence on the long-term effects of pharmacological management in children undergoing dental treatment. This study aimed to assess children's behavior in consecutive dental sessions following oral rehabilitation using different pharmacological regimens for behavioral control. Participants were preschoolers who were previously treated for caries under one of the following: no sedative, oral sedation with midazolam, oral sedation with midazolam/ketamine, or general anesthesia. The children's behavior in the follow-up sessions was assessed using the Ohio State University Behavioral Rating Scale (OSUBRS); higher scores represented less cooperative behavior (range 5-20). Follow-up assessments were conducted on 50 children under four years old for up to 29 months. Data were analyzed by the Friedman/Wilcoxon tests and Cox regression model. OSUBRS mean (standard deviation) scores for the whole sample decreased from 11.9 (5.4) before treatment to 6.8 (3.2) at the final recall session (p < 0.001). Moderate sedation with midazolam (OR 2.9, 95%CI 1.2-6.9) or midazolam/ketamine (OR 4.3, 95%CI 1.6-11.4) improved children's future behavior. The general anesthesia group (n = 4) had a small sample size and the results should be considered with caution. Although invasive dental treatment negatively affected the child's behavior in the dental chair, they became more cooperative over time. Moderately sedated children showed better prospective behavior than those in the non-sedation group.

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Comparison of oral ketamine and oral midazolam as sedative agents in pediatric dentistry

Cited by 32 publications

References 0 publications

Use of oral ketamine for analgesia during reduction/manipulation of fracture/dislocation in the Emergency Room: An initial experience in a low-resource setting

Use of oral ketamine for analgesia during reduction/manipulation of fracture/dislocation in the Emergency Room: An initial experience in a low-resource setting

Betamethasone Versus Ketamine for Attenuation of POST in Patients Undergoing Surgeries Under GA with Endotracheal Intubation- A Clinical Study

Moderate sedation helps improve future behavior in pediatric dental patients – a prospective study

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