Comparison of Oral Sulfate Solution and Polyethylene Glycol Plus Ascorbic Acid on the Efficacy of Bowel Preparation

Abstract

Background/Aims: The quality of bowel preparation is one of the quality indicators for colonoscopy. The aim of this study was to compare the efficacy of oral sulfate solution (OSS) and polyethylene glycol plus ascorbic acid (PEG-AA) for bowel preparation. Methods: The study involved 167 patients who underwent diagnostic colonoscopies. Inadequate bowel preparation was defined as any score of ≤1 in each colon section based on the Boston Bowel Preparation Scale. Multivariate logistic regression was used to compare the efficacy of OSS and PEG-AA. Subgroup analyses were performed based on patient characteristics. Results: Overall, 106 (63.5%) patients received OSS, and 61 (36.5%) patients received PEG-AA. The rate of inadequate bowel preparation was 12.3% in patients receiving OSS and 32.8% in patients receiving PEG-AA (p=0.001). OSS (odds ratio [OR] = 0.26; p=0.003) and morning examination (OR=0.11; p=0.038) were significantly associated with efficient bowel preparation. The efficacy of OSS compared with PEG-AA was only significant in patients ≥50 years of age vs. <50 years of age (OR=0.13; p=0.001 vs. OR=0.96; p=0.959) and female vs. male patients (OR=0.06; p=0.002 vs. OR=0.58; p=0.339). Conclusions: OSS was significantly more efficient for bowel preparation than PEG-AA, especially in patients ≥50 years of age and female patients. Morning examination led to a good quality of bowel preparation, irrespective of the preparation regimen. Clin Endosc 2020 Apr 24.

Comparison of Four Bowel Cleansing Agents for Colonoscopy and the Factors Affecting their Efficacy. A Prospective, Randomized Study

“…This discrepancy among results is probably due to the heterogeneous designs of the studies. Similar to our study, two previous studies that focused on bowel preparation quality and analyzed ADRs or PDRs did not find any significant differences among cleansing solutions [20,26]. The split-dose regimen was accepted most often in the 2L-PEG/Asc group (92%).…”

“…Many studies comparing quality of bowel preparation have already been published. There is a high degree of heterogeneity among the studies because of the different study designs, including different types of compared agents, administration, and evaluation scales [17][18][19][20][21][22][23][24][25][26]. The present study was a prospective, randomized, unicentric, and investigator-blinded study.…”

Bowel Preparation Instructions for Outpatient Colonoscopy Delivered by a Specialist Endoscopy Nurse was Superior to That Delivered by an Endoscopist

“…However, adequate bowel preparation is one of the most important factors associated with the optimal visualization of bowel mucosa and detection of polyps during colonoscopy [6,12]. Unsuccessful colonoscopy or failed colonoscopy, defined as a failure to intubate the cecum, can occur in 25-40% of the subjects with inadequate bowel preparation [13][14][15]. Inadequate bowel preparation is also as-sociated with a reduced adenoma detection rate (ADR), an increased in procedure time, an increased risk of colonoscopy associated complications and reduced surveillance intervals [14][15][16].…”

Oral Sulfate Solution is as Effective as 2 L Polyethylene Glycol Plus Ascorbic Acid

“…6 However, it has been reported that the rate of inadequate bowel preparation in the patients undergoing colonoscopy in real-life clinical practice is 25%-30%. 7,8 In this issue of Clinical Endoscopy, Nam et al 9 compared the efficacy of OSS and PEG-AA and identified the patient characteristics that were favorable in certain formulations. Overall, 106 (63.5%) patients received OSS and 61 (36.5%) patients received PEG-AA.…”

“…In this issue of Clinical Endoscopy , Nam et al [ 9 ] compared the efficacy of OSS and PEG-AA and identified the patient characteristics that were favorable in certain formulations. Overall, 106 (63.5%) patients received OSS and 61 (36.5%) patients received PEG-AA.…”