Comparison of oxidant/antioxidant balance in COPD and non-COPD smokers

Aydemir, Yusuf; Aydemir, Özlem; Şengül, Aysun; Güngen, Adil Can; Çoban, Hikmet; Taşdemir, Canatan; Düzenli, Hasan; Şehitoğulları, Abidin

doi:10.1016/j.hrtlng.2019.07.005

Cited by 19 publications

(14 citation statements)

References 17 publications

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“…It is known that smokers have significantly reduced levels of antioxidants in the body [103]. Cigarettes are a source of several thousand different chemical compounds, of which the vast majority can damage DNA, proteins, and other cellular structures directly or by generating massive free radicals and thus extremely increases the level of oxidative stress [104][105][106]. Moller et al have shown that supplementation with vitamin C through antioxidant-rich vegetables and fruit intake (250 g/day of broccoli, containing 146 mg of vitamin C) can be particularly beneficial for smokers.…”

Section: Vitamin C and Oxidative Dna Damagementioning

confidence: 99%

Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent

et al. 2020

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Vitamin C has been known for decades. It is common in everyday use as an element of the diet, supplementation, and a preservative. For years, research has been conducted to precisely determine the mechanism of action of ascorbate in the cell. Available results indicate its multi-directional cellular effects. Vitamin C, which belongs to antioxidants scavenging free radicals, also has a ‘second face’—as a pro-oxidative factor. However, whether is the latter nature a defect harmful to the cell, or whether a virtue that is a source of benefit? In this review, we discuss the effects of vitamin C treatment in cancer prevention and the role of ascorbate in maintaining redox balance in the central nervous system (CNS). Finally, we discuss the effect of vitamin C supplementation on biomarkers of oxidative DNA damage and review the evidence that vitamin C has radioprotective properties.

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Section: Vitamin C and Oxidative Dna Damagementioning

confidence: 99%

Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent

et al. 2020

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“…Although the baseline levels of oxidants are higher when compared to healthy subjects due to the inflammation maintained in the pathology, among other factors described above. The lipid peroxidation products, such as MDA and 8isoprostanes, decrease significantly throughout rehabilitation, but in comparison to the increase in antioxidant capacity and antioxidant enzymes as of training session 10, the concept of maintaining antioxidant characteristics as a long-time effect against oxidative injury is reinforced [23].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress Markers in COPD Patients Admitted to Pulmonary Rehabilitation

Romero-Dapueto¹,

Castillo²

2021

TORMJ

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Background: Chronic obstructive pulmonary disease (COPD) is a pathology, which leads to an irreversible and progressive reduction of the airflow, usually caused by smoking, but only present in 25% of smokers. Some mechanisms involved in the onset and progression of the disease are local and systemic factors such as inflammation, exacerbated immune response and the appearance of oxidative stress. For all these reasons, the use of oxidative stress parameters as progression markers or even as a way to monitor the response of any kind of non-pharmacological interventions, like the use of pulmonary rehabilitation (PR), is feasible. Aims: The study aims to determine markers of oxidative stress levels in plasma and erythrocytes in patients with COPD through the application of a PR protocol. Methods: The study included 25 patients diagnosed with COPD according to the GOLD criteria with a medical indication of PR and attendance at the gym in San José Hospital, Santiago, Chile. Blood samples were obtained before the start of the protocol, in the 10th session, and at the end of the protocol (20th session). These samples were stored for oxidative stress determinations: FRAP (ferric reducing ability of plasma), F2-isoprostanes, reduced (GSH)/oxidized (GSSG) ratio and antioxidant enzyme activity in the erythrocyte. In all stages, associations between events and clinical parameters in patients have been observed. The clinical parameters assessed were the six-minute walking test (6MWT), maximal inspiratory and expiratory pressure, the BODE index and Saint George’s respiratory questionnaire, which includes quality of life. Results: The intracellular and extracellular capacity (GSH/GSSG and FRAP) in patients in PR at the 10th session were 53.1 and 34% higher than basal values, respectively. Only the GSH/GSSG ratio was 38.2% lower at the 20th session, related in part with higher plasma and erythrocyte lipid peroxidation at baseline. This could be due to the high concentration of reactive oxygen species in the first sessions, which has been reported in the literature as the acute effect of controlled exercise. Blood lipid peroxidation was 43.34 and 58.34% lower at the 10th and 20th sessions, respectively, demonstrating the improvements in the oxidative parameters with long-term exercise. With respect to oxidative enzyme activity, superoxide dismutase and catalase showed higher values of activity at the 10th and 20th sessions compared to the baseline. In the clinical parameters of the PR, significant changes were found in the BODE index and Saint George’s questionnaire, with these results being associated with a less predictive mortality score and a better understanding of the disease. This may be because the patients achieved longer distances in the 6MWT and better understood the disease at the end of the PR. Conclusion: The goal of this study was to contribute to the pathophysiological basis for further research on COPD patients, a disease of high prevalence in Chile. This study could support the basis for non-pharmacological strategies such a PR.

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“…However, the antioxidant capacity values had not returned to normal levels 5-10 days after admission. 16 Previous studies that detected decreased TAS values defined stable COPD as those with 1 month 14,19 or 2 months 11 of period after last exacerbation. They did not state neither took in account precise time from the last exacerbation like we did in our study.…”

Section: Discussionmentioning

confidence: 99%

“…11 In stable COPD, there were reports of no significant differences of TAS, 12,13 as well as a significant decrease of TAS compared to controls. 11,14 In a study without the characteristics of disease activity, findings suggested a lower TAS in patients compared to healthy controls, confirming a presence of systematically oxidantantioxidant imbalance in COPD patients. 15 Some authors found a significant reduction in TAS only in exacerbation of COPD.…”

Section: Introductionmentioning

confidence: 90%

<p>Total Antioxidant Status in Stable Chronic Obstructive Pulmonary Disease</p>

Hlavati¹,

Tomić

Buljan

et al. 2020

COPD

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This study evaluates the total antioxidant status (TAS) in plasma of stable chronic obstructive pulmonary disease (COPD) patients. Earlier studies of their relationship showed inconsistent findings. Patients and Methods: We compared TAS between 90 COPD patients and 30 age-and sex-matched controls (mean age 67 ± 7.9, 87 males and 33 females) according to airway obstruction severity, gender, smoking status (current/ former/ non-smoker), smoking-dose, the number of exacerbations in the previous year, nutritional status and hypercapnia. Results: There were no differences in pack-years between COPD and controls, neither in COPD groups. The median time from the last exacerbation was 5 months (interquartile range 3−8.3). TAS was significant higher in COPD than controls (1.68 [1.55−1.80] versus 1.59 [1.54−1.68], respectively; P = 0.03). TAS was significantly higher in COPD men than women (1.7 [1.6−1.8] versus 1.57 [1.5−1.7], respectively; P = 0.001). In COPD groups, there were no significant differences between the severity of airway obstruction and TAS. We found significant positive correlation between pack-years and TAS in all participants (Rho = 0.429, P = 0.004) and COPD patients (Rho = 0.359, P = 0.02), but not in controls. TAS was a significant predictor of COPD (β = 3.26; P = 0.04; OR = 26.01; 95% CI: 1.20 to 570.8). We failed to find significant differences between TAS and smoking status, frequency of exacerbations in the previous year, nutritional status and hypercapnia. Conclusion: TAS was a significant predictor of COPD. TAS was a significantly higher in stable COPD than controls, higher in COPD men than women, but there was no significant correlation between TAS and the airway obstruction severity. Our results suggest that it could be appropriate to include the time from the last exacerbation in the oxidant-antioxidant balance analysis of COPD patients.

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Comparison of oxidant/antioxidant balance in COPD and non-COPD smokers

Cited by 19 publications

References 17 publications

Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent

Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent

Oxidative Stress Markers in COPD Patients Admitted to Pulmonary Rehabilitation

<p>Total Antioxidant Status in Stable Chronic Obstructive Pulmonary Disease</p>

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