Comparison of oximes K203 and K027 based on Benchmark dose analysis of rat diaphragmal acetylcholinesterase reactivation

Antonijević, Evica; Musílek, Kamil; Kuča, Kamil; Djukic-Cosic, Danijela; Andjelković, Milena; Djordjevic, Aleksandra Buha; Antonijević, Biljana

doi:10.1016/j.cbi.2019.05.034

Cited by 5 publications

(2 citation statements)

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“…Also, for the first time, Antonijevic et al have introduced BMD to assess the effectiveness of antidote in a study in which acute i.m. dichlorvos exposure of rats was followed by the reactivation of acetylcholinesterase in erythrocytes and diaphragm by K203 and K027 oximes ( Figure 1B) (24,26,29). It can also be applied to establish health based exposure limits in risk identification in the process of manufacture of various medicinal products in shared facilities (30).…”

Section: Bmd Approach For Pod Calculationmentioning

confidence: 99%

“…The BMD approach has mostly been applied in the developmental toxicity studies (12,(15)(16)(17)(18) and neurotoxicity (12,15,18,19). In addition, recently published data indicate the other ways in which the BMD approach could be applied in toxicology (18,(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). The experience of our research group includes the use of a BMD approach in evaluating the toxic effects of decabrominated diphenyl ether BDE-209 in subacute orally exposed Wistar rats ( Figure 1A) (25,28), as well as polychlorinated biphenyls after subacute oral exposure of rats (23,27).…”

Section: Bmd Approach For Pod Calculationmentioning

confidence: 99%

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Relevance and evaluation of the benchmark dose in toxicology

Baralić¹,

Javorac²,

Antonijević³

et al. 2020

Arhiv za farmaciju

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This paper aims to present the importance of the benchmark dose (BMD) as a point of departure (the lowest dose or concentration in the experiment that deviates from the response that differs from the normal response) in toxicological risk assessment, as well as to present commonly used software for its calculation (BMDS and PROAST). Benchmark dose is defined as a statistical lower confidence limit of a dose that results in a small change in effect (5-10%) in comparison with the control value. The BMD approach is considered a substitution for the NOAEL approach, which uses the highest observed no-effect level (NOAEL) to obtain the reference dose. The BMD approach is a methodically more forward-thinking technique than the NOAEL approach because it has statistical power and provides a wide range of dose-response relationships and allows the determination of their uncertainty and variability. Moreover, the BMD approach contributes to the reduction of experimental animals in toxicity studies. Therefore, the European Food Safety Authority (EFSA) recommends the use of BMDL10 values for quantal and BMDL05 for continuous data.

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Section: Bmd Approach For Pod Calculationmentioning

confidence: 99%