Comparison of Persistent Organic Pollutant Residues in Serum and Adipose Tissue in a Female Population in Belgium, 1996-1998

Abstract

This study was performed to determine and compare persistent organic pollutant (POP) levels in different matrices in a female population. A total of 96 serum and 46 adipose tissue samples were collected from infertile women (n = 101) attending Centers for Reproductive Medicine in Belgium from 1996 to 1998. Gas chromatography with electron-capture detection was used to quantify residue levels on a lipid basis of seven organochlorine pesticides (OCPs) and seven polychlorinated biphenyls (PCBs). There was a strong association between adipose tissue and serum residues. The adipose tissue levels of CB-138, 153, 180 and p,p'-DDE were explained by the serum residues. Besides, the accumulation pattern for CB-153 and CB-180 in serum and adipose tissue are mirror images of each other.

Hydroxy-PCBs, PBDEs, and HBCDDs in Serum from an Elderly Population of Swedish Fishermen's Wives and Associations with Bone Density

“…Σ3OH-PCBs as presented in this study are on a level similar to that of CB-153, and within the previously mentioned range. Both CB-153 and Σ3OH-PCB are considerably higher than reported serum levels in general populations in Europe at the same time period (40,(42)(43)(44), but comparable with CB-153 concentrations in an elderly population of Swedish women (54-75 years old) (45). The PCB levels and hydroxylated metabolites are also comparable with a hot-spot exposure area in Slovakia (46), and in the Faeroe Islands (47), as well as with high and low fish consumers in Sweden, Latvia (23), and Finland (48).…”

The Use and Fate of Pesticides in Vegetable-Based Agro-Ecosystems in Ghana

“…The eluent was concentrated by a stream of nitrogen gas to 1 mL and then, quantification and confirmation of results were made using gas chromatography-electron capture detection (GC-ECD) and gas chromatography-mass spectrometer (GC-MS). Complete details of the gravimetric measurement of the lipid percentage of blood serum are described elsewhere (Pauwels et al, 2000).…”

“…The different modes of origin and the different lipid contents probably lead to selective accumulation. The lipids of blood serum consist of phospholipids and two simple lipids, fatty acid esters of glycerol and cholesterol and free cholesterol and those of breast milk are mainly the simple glycerides (Pauwels et al, 2000). Among the OCs analysed, dieldrin was found at highest levels in all the samples (milk and blood) up to 1265.4 ng/g (data not shown), followed by other compounds in the order of DDTs > HCHs > HCB with mean concentrations 1-4 orders of magnitude less than those of dieldrin.…”

“…Collection of adipose tissue involves invasive surgical removal of tissues. Therefore, a biological matrix, such as blood and breast milk or their components, that can be obtained with a less invasive procedure than adipose tissue is highly desirable (Pauwels et al, 2000) and they have become common tissues for measuring OC levels in humans (Cerrillo et al, 2005;Kunisue et al, 2004aKunisue et al, , 2004bMinh et al, 2004;Sudaryanto et al, 2005;Sun et al, 2005;Waliszewski et al, 2001). However, serum is usually preferred over whole blood due to the minor complexity of the matrix and because it is a more homogenous material (Lino and Silveira, 2006).…”

“…However, serum is usually preferred over whole blood due to the minor complexity of the matrix and because it is a more homogenous material (Lino and Silveira, 2006). While several reports on organochlorine contaminants in human tissues (adipose tissue, milk or serum) have been published for other countries Cerrilo et al, 2005;Jaraczewska et al, 2006;Kunisue et al, 2004aKunisue et al, , 2004bLino and da Silveira, 2006;Muñoz-de-Toro et al, 2006;Pauwels et al, 2000;Poon et al, 2005;Sun et al, 2005;Waliszewski et al, 2001), there is insufficient documentation for Ghana, especially for recent years.…”