Comparison of physicochemical properties of suppositories containing starch hydrolysates

Belniak, Piotr; Świąder, Katarzyna; Szumiło, Michał; Hyla, Aleksandra; Poleszak, Ewa

doi:10.1016/j.jsps.2016.09.004

Cited by 15 publications

(8 citation statements)

References 11 publications

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“…Moreover, percent total reflux time, the number of refluxes and the number of refluxes lasting for more than 5 min all were significantly low in the research group, p<0.05. This fully indicates the effectiveness of domperidone in the treatment of reflux gastritis, which is consistent with previously reported studies [10][11][12][13][14][15][16] .…”

supporting

confidence: 93%

The Clinical Effect of Domperidone on Reflux Gastritis

Sui¹,

Deng²,

Jin³

et al. 2020

pharmaceutical-sciences

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Sui et al.: Domperidone on Reflux GastritisThe present clinical study observed the effect of domperidone on reflux gastritis. In this study, 200 patients with reflux gastritis were divided into the control group accepting routine drug therapy and the research group accepting domperidone treatment, each group contained 100 patients. The overall treatment efficiency, clinical symptom score before and after treatment and bile reflux monitoring indicators 24 h after treatment were compared between the two groups. On comparing the overall treatment efficiency of patients in both groups, the results showed that the research group was 96.00 % and the control group was 80.00 %. The score of clinical symptoms of the two groups of patients showed that the degree of improvement in the research group was significantly better than that in the control group after treatment, p<0.05. By comparing the monitoring indexes of bile reflux 24 h after treatment between the two groups, the research group had significant advantages in terms of the percent total reflux time, the number of refluxes and the number of refluxes lasting for more than 5 min. The application of domperidone in the treatment of reflux gastritis can significantly improve the therapeutic effect, improve the clinical symptoms and promote the recovery of patients as soon as possible.

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supporting

confidence: 93%

The Clinical Effect of Domperidone on Reflux Gastritis

Sui¹,

Deng²,

Jin³

et al. 2020

pharmaceutical-sciences

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“…Daugelis mokslinių tyrimų įrodo ir teigia, kad labai svarbu parinkti tokį pagrindą ir pagalbines medžiagas, kurios suformuotų geriausias biofarmacines savybes ir nepakeistų veikliosios medžiagos fizikinių ir cheminių savybių [4,5]. Pagalbinių medžiagų savybės gali turėti įtakos ne tik vaistinių medžiagų kiekio atpalaidavimui iš žvakučių, bet ir atpalaidavimo greičiui [6][7][8].…”

Section: įVadasunclassified

Pagalbinių Medžiagų Poveikio Vaistinių Medžiagų Atpalaidavimui Iš Skirtingų Žvakučių Pagrindų Tyrimas

Inkėnienė¹,

Ramanauskienė²,

Borkertaitė³

et al. 2021

Health Sciences

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Žvakučių pagrindas turi didelę įtaką vaisto biologiniam pasisavinimui rektaliniu ir vaginaliniu vartojimo būdu, terapiniam aktyvumui ir pasiskirstymui. Daugelis mokslinių tyrimų įrodė, kad labai svarbu parinkti tokį pagrindą ir pagalbines medžiagas, kurios suformuotų geriausiasbiofarmacines savybes, nepakeisdamos veikliosios medžiagos fizikinių ir cheminių savybių. Pagalbinių medžiagų savybės gali turėti įtakos ne tik vaistinių medžiagų kiekio atpalaidavimui iš žvakučių, bet ir atpalaidavimo greičiui. Vaistinė medžiaga gali būti absorbuojama po pavartojimo, kai atpalaiduojama iš pagrindo. Biologinis vaistinių medžiagų pasisavinimas iš žvakučių priklauso nuo pagrindo ir pagalbinių medžiagų, jų koncentracijos. Aktualu tirti medžiagų atpalaidavimo priklausomybę nuo žvakučių pagrindo, gamybos būdo ir pagalbinių medžiagų. Tyrimo problema: kaip šie veiksniai paveikia vaistinės medžiagos atpalaidavimą iš žvakučių? Tyrimo objektas − pagalbinių medžiagų įtaka vaistinių medžiagų atpalaidavimui iš skirtingų pagrindų žvakučių. Tyrimo tikslas − biofarmaciniu tyrimu in vitro atskleisti pagrindo, pagalbinių medžiagų, gamybos būdo įtaką vaistinių medžiagų atpalaidavimui iš hidrofobinių (kakavos sviesto), ir hidrofilinių (želatinos – glicerolio ir polietilenglikolio) žvakučių pagrindų. Žvakučių suirimo testu nustatyta, kad pagalbinių medžiagų − plastifikatorių, tirštiklių (lanolino, bičių vaško, koloidinio silicio dioksido) įterpimas prailgina suirimo laiką. Tiek hidrofobinio, tiek hidrofilinio pagrindo žvakučių suirimo laikas neviršijo Europos Farmakopėjoje reglamentuojamo suirimo laiko ribų. Lipofilinio pagrindo žvakutės suiro greičiau, nei hidrofilinio. Biofarmacinis tirpimo tyrimas in vitro parodė, kad žvakučių pagrindas turi reikšmės vaistinių medžiagų atpalaidavimui iš žvakučių. Daugiausiai ir greičiausiai tirtos vaistinės medžiagos atsipalaidavo iš hidrofilinių želatinos-glicerolio pagrindų, lyginant su lipofiliniais kakavos sviesto pagrindais, polietilenglikolio pagrindas pailgino žvakučių surimo laiką ir sulėtino fenolinių junginių atpalaidavimą iš pagrindo. Pastebėta, kad lipofilinių pagrindų gamybos būdas yra svarbus veiksnys – ritinimo būdu pagamintos žvakutės atpalaidavo vaistinės medžiagos daugiau ir greičiau, nei tos pačios sudėties liejimo būdu pagamintas pagrindas.

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“…The disintegration time was recorded as soon as the suppositories placed in the basket were completely dissolved. (Loyd et al, 2013;Belniak et al, 2017;Onyeji et al, 1999;Hargoli et al, 2013).…”

Section: Determination Of the Disintegration Timementioning

confidence: 99%

Application of design mixture and desirability function in the optimization of pharmaco-technical parameters of macrogols-based suppositories

Benomar

Yanisse

Charkaoui

et al. 2020

ijrps

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The objective of this work is to (i) study the effect of variations in the proportions of four Macrogols on the pharmaco-technical characteristics of suppositories, (ii) define the optimal formula for a suppository with immediate effect; maximum disintegration and a minimum of hardness as defined in the European Pharmacopoeia. The lattice design mixture has been proposed as an optimization technique, the formulation factors are presented by the proportions of PEG 400 (X1), PEG 600 (X2), PEG 4000 (X3) and PEG 6000 (X4) and the response variables are (i) the disintegration time (Y1) (ii) the hardness (Y2). The second-degree empirical model was postulated to model the variations of the two response variables using the least-squares method. The selected model explained about 67% and 84% of the variation for Y1 and Y2, respectively. All four factors had significant effects on the properties of the suppository. Interactions negatively affected both responses. The numerical desirability method gave the following optimal formula: PEG400 (28.71334 %); PEG600 (24.23773%), PEG4000 (35.00944%) and PEG6000 (12.03949%) for a disintegration of 25.839 (+/-2.3) min and hardness =2147.321 (+/- 50) g.

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Comparison of physicochemical properties of suppositories containing starch hydrolysates

Cited by 15 publications

References 11 publications

The Clinical Effect of Domperidone on Reflux Gastritis

The Clinical Effect of Domperidone on Reflux Gastritis

Pagalbinių Medžiagų Poveikio Vaistinių Medžiagų Atpalaidavimui Iš Skirtingų Žvakučių Pagrindų Tyrimas

Application of design mixture and desirability function in the optimization of pharmaco-technical parameters of macrogols-based suppositories

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