Comparison of Planned Dose Distributions Calculated by Monte Carlo and Ray-Trace Algorithms for the Treatment of Lung Tumors With CyberKnife: A Preliminary Study in 33 Patients

Wilcox, Ellen E.; Daskalov, George M.; Lincoln, Holly; Shumway, Richard; Kaplan, Bruce M.; Colasanto, Joseph M.

doi:10.1016/j.ijrobp.2009.08.001

Cited by 62 publications

(44 citation statements)

References 31 publications

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“…For small fields in highly inhomogeneous areas, for example, lung tumors, mean differences of 20% have been observed for individual beam dose calculation for ray-tracing vs Monte Carlo 27,28 (Fig. 4).…”

Section: Iid Treatment Planning Software-qa and Safetymentioning

confidence: 98%

Report of AAPM TG 135: Quality assurance for robotic radiosurgery

et al. 2011

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The task group (TG) for quality assurance for robotic radiosurgery was formed by the American Association of Physicists in Medicine's Science Council under the direction of the Radiation Therapy Committee and the Quality Assurance (QA) Subcommittee. The task group (TG-135) had three main charges: (1) To make recommendations on a code of practice for Robotic Radiosurgery QA; (2) To make recommendations on quality assurance and dosimetric verification techniques, especially in regard to real-time respiratory motion tracking software; (3) To make recommendations on issues which require further research and development. This report provides a general functional overview of the only clinically implemented robotic radiosurgery device, the CyberKnife V R . This report includes sections on device components and their individual component QA recommendations, followed by a section on the QA requirements for integrated systems. Examples of checklists for daily, monthly, annual, and upgrade QA are given as guidance for medical physicists. Areas in which QA procedures are still under development are discussed.

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Section: Iid Treatment Planning Software-qa and Safetymentioning

confidence: 98%

Report of AAPM TG 135: Quality assurance for robotic radiosurgery

et al. 2011

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“…On the other hand, we based our study only on geometrical uncertainties and not on CTV coverage; the E2E accuracy is a mixture of both terms, as radiation is delivered. We used a purely geometrical approach because we believe that the PTV margin definition used by van Herk et al (37) is not directly applicable at this time in the CyberKnife system (“The PTV is a geometrical concept … taking into consideration the net effect of all the possible geometrical variations and inaccuracies in order to ensure that the prescribed dose is actually absorbed in the CTV”), as the treatment planning algorithm used to date has a much more significant impact on the correct dose for tumor coverage 38 , 39 , 40 and real optimal dose prescription (41) . Therefore, the clinical implication of the margin selected is unclear.…”

Section: Discussionmentioning

confidence: 99%

Retrospective evaluation of CTV to PTV margins using CyberKnife in patients with thoracic tumors

Floriano

García²,

Moreno³

et al. 2014

J Applied Clin Med Phys

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The objectives of this study were to estimate global uncertainty for patients with thoracic tumors treated in our center using the CyberKnife VSI after placement of fiducial markers and to compare our findings with the standard CTV to PTV margins used to date. Datasets for 16 patients (54 fractions) treated with the CyberKnife and the Synchrony Respiratory Tracking System were analyzed retrospectively based on CT planning, tracking information, and movement data generated and saved in the logs files by the system. For each patient, we analyzed all the main uncertainty sources and assigned a value. We also calculated an expanded global uncertainty to ensure a robust estimation of global uncertainty and to enable us to determine the position of 95% of the CTV points with a 95% confidence level during treatment. Based on our estimation of global uncertainty and compared with our general margin criterion (5 mm in all three directions: superior/inferior [SI], anterior/posterior [AP], and lateral [LAT]), 100% were adequately covered in the LAT direction, as were 94% and 94% in the SI and AP directions. We retrospectively analyzed the main sources of uncertainty in the CyberKnife process patient by patient. This individualized approach enabled us to estimate margins for patients with thoracic tumors treated in our unit and compare the results with our standard 5 mm margin.PACS number: 87.55‐x

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“…Two authors compared dose distributions calculated with EPL and MC for CyberKnife treatment. Wilcox et al reported that the maximum doses calculated by the EPL to target PTV were uniformly larger (up to a factor of 1.63) than the MC ones, depending on the target size and location [19]. She demonstrated that the degree of underdosing significantly varied from patient to patient and that a quantitative estimate of the differences could be achieved only after a complete analysis of each individual plan.…”

Section: Treatment Planningmentioning

confidence: 99%

The CyberKnife radiosurgery system for lung cancer

Nuyttens¹,

Pol

2012

Expert Review of Medical Devices

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The CyberKnife is a frameless image-guided radiotherapy system involving a 6-MV linear accelerator mounted on a robotic arm. The imaging system consists of two diagnostic x-ray sources mounted to the ceiling paired with amorphous silicon detectors to acquire live digital radiographic images of the tumor or tumor surrogates including bony anatomy or implanted fiducial markers. The Synchrony system enables 4D real-time tracking of tumors that move with respiration. Owing to this complex system, moving tumors can be treated with an accuracy of 2 mm or less while patients breathe normally. Clinical results of inoperable patients with peripheral early-stage lung cancer are excellent. The toxicity is low and the treatment does not result in a loss in quality of life.

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Comparison of Planned Dose Distributions Calculated by Monte Carlo and Ray-Trace Algorithms for the Treatment of Lung Tumors With CyberKnife: A Preliminary Study in 33 Patients

Cited by 62 publications

References 31 publications

Report of AAPM TG 135: Quality assurance for robotic radiosurgery

Report of AAPM TG 135: Quality assurance for robotic radiosurgery

Retrospective evaluation of CTV to PTV margins using CyberKnife in patients with thoracic tumors

The CyberKnife radiosurgery system for lung cancer

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