Comparison of plasma nucleotide metabolites and amino acids pattern in patients with binge eating disorder and obesity

Abstract

Binge eating disorder (BED) increasingly affects population, but the mechanisms of the disease and its biomarkers are not well characterized. Recently, plasma purines, pyrimidines, amino acid and nicotinamide metabolites profiling attracted attention in studies on pathology and biomarkers of mental disorders but has not been adequately studied in BED. Blood and plasma samples were taken from patients with adult obese with BED (n ¼ 20) and control adult obese without BED (n ¼ 17). Plasma samples were analyzed for nucleotides and amino acid concentrations with high-performance liquid chromatography-mass spectrometry. BED had a significantly (p < 0.05) lower uridine and hypoxanthine to creatinine ratio compared to the control group. Among the amino acids BED patients had significantly (p < 0.05) lower concentrations of glutamic acid, leucine, isoleucine and the whole branchedchain amino acids group, while the concentration of citrulline was increased. Among nicotinamide metabolites, 1-methylnicotinamide levels were significantly (p < 0.05) lower. This study highlights potential use of profiling nucleotide metabolite and amino acid pattern in BED patients that may provide information on mechanisms and potential biomarkers. However, further investigation in larger population is necessary to identify clinical correlates of the observed changes.

Sodium Butyrate Attenuates AGEs-Induced Oxidative Stress and Inflammation by Inhibiting Autophagy and Affecting Cellular Metabolism in THP-1 Cells

“…Glutamic acid is the most abundant amino acid in the human body, which provides energy for cell metabolism. It is also the hub of the transformation of purine, pyrimidine, amino sugar, and other amino acids in the body [47,48]. In addition to this, glutamine also participates in the immune response [49,50].…”

Salivary Metabolomic Signatures and Body Mass Index in Italian Adolescents: A Pilot Study

“…Our results aligned with previous studies showing associations between plasma and serum metabolomics data and metabolic outcomes. Epidemiological studies have suggested that levels of nucleotide metabolites are altered in obese adult populations [ 61 , 62 ] and could play a role in adipocyte functioning [ 63-65 ]. Plasma levels of nucleosides—pyrimidines and purines—were also found to be dysregulated in relation to obesity in children [ 44 ].…”

Au Nanoparticles on 4-Thiophenol-Electrodeposited Carbon Surfaces for the Simultaneous Detection of 8-Hydroxyguanine and Guanine

“…The information which pertains to the proper transcription of proteins is stored in the form of nitrogenous bases, the four most recognized being adenine, thymine, cytosine, and guanine (G). In addition to these nucleobases functioning as the genetic code of organisms, they also have several metabolic functions in extracellular signaling pathways [4,5]. Any changes made to the arrangement of the four nitrogenous bases or harm caused to them can potentially modify the sequence of the protein it transcribes, and hence, it may change the structure of the organism as well as trigger the emergence of specific illnesses [6].…”