Comparison of plateletpheresis on the Fenwal Amicus, Fresenius COM.TEC, and Trima Accel Cell separators

Abstract

Blood component donations by apheresis have become more common in modern blood transfusion practices. We compared three apheresis instruments (Fenwal Amicus, Fresenius COM.TEC, and Trima Accel) with regard to platelet (PLT) yield, collection efficiency (CE), and collection rate (CR). The single-needle or double-needle plateletpheresis procedures of the three instruments were compared in a retrospective, randomized study in 270 donors. The blood volume processed was higher in the COM.TEC compared with the Amicus and Trima. Also there was a significantly higher median volume of ACD used in collections on the COM.TEC compared with the Amicus and Trima. The PLT yield was significantly lower with the COM.TEC compared with the Amicus and Trima. Additionally, the CE was significantly lower with the COM.TEC compared with the Amicus and Trima. There was no significant difference in median separation time and CR between the three groups. When procedures were compared regarding CE by using Amicus device, it was significantly higher in single-needle than double-needle plateletpheresis. When double-needle Amicus system was compared with double-needle COM.TEC system, CE and PLT yield were significantly higher with Amicus system. When single-needle Amicus system was compared with single-needle Trima system, CE and PLT yield were significantly higher with Trima system. All instruments collected PLTs efficiently. However, the CE was lower with the COM.TEC compared with the Amicus and Trima. Also, we found Amicus single-needle system collected PLTs more efficiently compared with the double-needle system. CE and PLT yields were significantly higher with the single-needle Trima instrument compared with the single-needle Amicus device.

Plateletpheresis efficiency and mathematical correction of software‐derived platelet yield prediction: A linear regression and ROC modeling approach

“…The median actual PLT yield in our donors was 5.96 × 10 11 . This finding is comparable to other reports in which PLT yields collected by Trima Accel cell separator varied between 4.5 × 10 11 and 7.48 × 10 11 . Almost all of our concentrates (97.36%) met the AABB criteria, which establishes that 75% of the single donor products must contain ≥ 3 × 10 11 PLTs, while all of them had ≥ 2 × 10 11 PLTs per unit, meeting the European guidelines, thus validating Trima v6.0 performance.…”

A hospital based retrospective study of factors influencing therapeutic leukapheresis in patients presenting with hyperleukocytic leukaemia

“…Existing blood cell separators apply the principle of gradient density difference; however, minimal density difference between each blood component (1.6–2.2%) 17 – 20 , and different blood cells in terms of volume and density has certain degree of overlap, so there are large platelets and red blood cell contaminated in leucocytes in the process of leukapheresis in clinic. A large number of platelets lost by patients in a short time resulted in a significant increased risk of late chemotherapy and delayed the opportunity for better treatment.…”

Apheresis-Adverse Events in Man and Machine Individualities

“…Donor demography, hematological values & procedural factors in platelet pheresis (n=1455)MCS+in the current study, Tendulkar and Rajadhyaksha observed anticoagulant use with the Cobe compared to Amicus10 . In another study by Keklik et al, the Trima and Amicus were comparable with regard to all parameters, except PLT yield and collection efficiency which was better with the Trima compared to Hemonetics MCS+11 .…”