Comparison of Postsurgical Scars Between Vegan and Omnivore Patients

Fusano, Marta; Fusano, Isabella; Galimberti, M.; Bencini, M.; Bencini, Pier Luca

doi:10.1097/dss.0000000000002553

Cited by 11 publications

(5 citation statements)

References 27 publications

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“…Several anecdotal cases had focused on vegetarian diet in humans with discordant results in establishing a potential cause-effect link between furocumarin-rich foods intake and a potential photosensitivity modification, conversely we found that a higher dietary intake of furocumarins in vegan and vegetarian diets is associated with greater skin sensitivity to NB-UVB phototherapy in psoriatic patients. Due to the increased prevalence of vegans and vegetarians among psoriatic patients [ 35 ], dermatologists started to evaluate potential differences in clinical outcomes and therapeutic management [ 36 , 37 ]. Although the Mediterranean diet, which is rich in vegetables, is regarded as beneficial for psoriatic patients [ 1 ], the impact of the single-food ingredients on phototherapy is entirely unknown.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diet-Related Phototoxic Reactions in Psoriatic Patients Undergoing Phototherapy: Results from a Multicenter Prospective Study

et al. 2021

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Vegans and vegetarians often consume foods containing photosensitizers capable of triggering phytophotodermatitis. The potential effect of vegan and vegetarian diets on the response of psoriatic patients undergoing phototherapy is not well characterized. We assessed clinical outcomes of vegan, vegetarian and omnivore adult psoriatic patients undergoing band ultraviolet B phototherapy (NB-UVB). In this multicenter prospective observational study, we enrolled 119 adult, psoriatic patients, of whom 40 were omnivores, 41 were vegetarians and 38 were vegans, with phototherapy indication. After determining the minimum erythemal dose (MED), we performed NB-UVB sessions for 8 weeks. The first irradiation dosage was 70.00% of the MED, then increased by 20.00% (no erythema) or by 10.00% (presence of erythema) until a maximum single dose of 3 J/cm2 was reached and constantly maintained. All the enrolled patients completed the 8 weeks of therapy. Severe erythema was present in 16 (42.11%) vegans, 7 (17.07%) vegetarians and 4 (10.00%) omnivores (p < 0.01). MED was lowest among vegans (21.18 ± 4.85 J/m2), followed by vegetarians (28.90 ± 6.66 J/m2) and omnivores (33.63 ± 4.53 J/m2, p < 0.01). Patients with severe erythema were more likely to have a high furocumarin intake (OR 5.67, 95% CI 3.74–8.61, p < 0.01). Vegans consumed the highest amount of furocumarin-rich foods. A model examining erythema, adjusted for gender, age, skin type, MED, phototherapy type, number of phototherapies and furocumarin intake, confirmed that vegans had a lower number of treatments. Vegans had more frequent severe erythema from NB-UVB, even after adjustment of the phototherapy protocol for their lower MED. Assessing diet information and adapting the protocol for vegan patients may be prudent.

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Section: Discussionmentioning

confidence: 99%

“…To further empower this statement, small amounts of dietary intake of furocumarins were reported to trigger photoxicity in both PUVA and NB-UVB [ 20 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Diet-Related Phototoxic Reactions in Psoriatic Patients Undergoing Phototherapy: Results from a Multicenter Prospective Study

et al. 2021

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“…They found that wound diastasis was more prevalent among vegans, and after a 6-month period, vegan patients had higher modified SCAR scores compared to omnivores, indicating more pronounced scar spread, a higher incidence of atrophic scars, and a poorer overall impression. Finally, they concluded that a vegan diet may have a detrimental impact on the outcome of surgical scars [ 44 ] Table 1 .…”

Section: Plant-based Diet Effects On Other Skin Conditionsmentioning

confidence: 99%

Beneficial Effects of Plant-Based Diets on Skin Health and Inflammatory Skin Diseases

Flores-Balderas,

Peña-Peña,

Rada

et al. 2023

Nutrients

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The human skin is a crucial organ that protects the organism from the outer environment. Skin integrity and health depend on both extrinsic and intrinsic factors. Intrinsic factors such as aging and genetic background contribute to weakened skin and disease susceptibility. Meanwhile, extrinsic factors including UV radiation, pollution, smoking, humidity, and poor diet also affect skin health and disease. On the other hand, healthy dietary patterns such as plant-based diets have gained popularity as a complementary therapy for skin health. A plant-based diet is defined as all diets based on plant foods, including an abundance of vegetables, fruits, beans, lentils, legumes, nuts, seeds, fungi, and whole grains, with limited or no animal products or processed foods. However, some authors also exclude or limit processed foods in the definition. Recent research has shown that these diets have beneficial effects on inflammatory skin diseases. This review explored the beneficial effects of plant-based diets on inflammatory skin diseases and plant-based functional foods on healthy skin. In conclusion, plant-based diets and plant-based functional foods may have beneficial effects on skin health through the gut microbiome.

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“…On the contrary, proper preoperative feeding stimulates the healing process, since certain nutrients (such as glutamine, arginine, butyrate, and antioxidants) play an important role in regulating broblast proliferation and regulating type I and III collagen deposition [18]. A vegan diet has been reported to exert a negative impact on the outcome of surgical scars [19]. Therefore, evaluating the preoperative nutritional status of patients is crucial for the early rise and prevention of HS formation.…”

Section: Introductionmentioning

confidence: 99%

Influence of Preoperative Pro-Inflammatory Cytokines and Nutritional Status on Skin Scar Hyperplasia

湘,

张,

卢

et al. 2023

Preprint

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Skin scar hyperplasia is a common complication following surgical procedures. We aimed to investigate certain sensitive indicators of hypertrophic scars formation and search potential strategies for reducing scar formation. Therefore, our objective was to collecte nutritional status, blood samples, and scar tissue samples from 123 patients undergoing internal fixation surgery between 2019 and 2022. Patients were classified into the hypertrophic scar (HS) group (n=33) and the non-hypertrophic scar (NHS) group (n=90) based on the degree of skin scar hyperplasia one year after surgery. Preoperative inflammatory factor (CRP, white blood cell, lymphocyte%, neutrophil%, monocyte%, IL-5, IL-6, IL-12p70, INF-γ) levels and nutritional status (ideal body weight (%), weight loss, lymphocyte, blood albumin, transferrin, pre-albumin) were measured by the blood test. RNA sequencing was used to test the tissue samples to explore related signaling pathways involving hypertrophic scars formation. In this study, we demonstrated the higher pro-inflammatory cytokine levels (CRP, neutrophil%, monocyte%, and IL-12p70)and worse nutritional status（ideal body weight, Lymphocyte, and Blood Albumin） occur in the HS group, with statistically significant difference (p < 0.05). In addition, Differential gene analysis found higher gene expression levels of inflammatory response, cell proliferation, and angiogenesis pathways in the HS group. Elevated preoperative inflammatory levels and poor nutritional status have significant effects on skin scar formation after surgery due to the role of pro-inflammatory cytokines in scar formation. Therefore, improving nutritional levels and controlling preoperative inflammation might be potential strategies for reducing scar formation. Trial registration number: ChiCTR2300069087 Date of registration: 2023-03-06

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Comparison of Postsurgical Scars Between Vegan and Omnivore Patients

Cited by 11 publications

References 27 publications

Diet-Related Phototoxic Reactions in Psoriatic Patients Undergoing Phototherapy: Results from a Multicenter Prospective Study

Diet-Related Phototoxic Reactions in Psoriatic Patients Undergoing Phototherapy: Results from a Multicenter Prospective Study

Beneficial Effects of Plant-Based Diets on Skin Health and Inflammatory Skin Diseases

Influence of Preoperative Pro-Inflammatory Cytokines and Nutritional Status on Skin Scar Hyperplasia

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