Comparison of pre-analytical conditions for quantification of serotonin in platelet-poor plasma

Volkmann, Hilde Løland von; Brønstad, Ingeborg; Fiskerstrand, Torunn; Gudbrandsen, Oddrun Anita

doi:10.1016/j.plabm.2019.e00136

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…In our analysis, we understood that the source of a blood-derived sample (i.e., whole blood, platelets, platelet-rich or platelet-poor plasma) has a marked influence on serotonin concentrations, with the vast majority of serotonin in the blood being stored in platelets 68 – 70 . Although we used rigorous, standardized PDBP protocols for total plasma collection, we did not measure serotonin in these various compartments or completely deplete the plasma of platelets.…”

Section: Discussionmentioning

confidence: 99%

Low plasma serotonin linked to higher nigral iron in Parkinson’s disease

Jellen

Lewis

et al. 2021

Sci Rep

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A growing body of evidence suggests nigral iron accumulation plays an important role in the pathophysiology of Parkinson’s disease (PD), contributing to dopaminergic neuron loss in the substantia nigra pars compacta (SNc). Converging evidence suggests this accumulation might be related to, or increased by, serotonergic dysfunction, a common, often early feature of the disease. We investigated whether lower plasma serotonin in PD is associated with higher nigral iron. We obtained plasma samples from 97 PD patients and 89 controls and MRI scans from a sub-cohort (62 PD, 70 controls). We measured serotonin concentrations using ultra-high performance liquid chromatography and regional iron content using MRI-based quantitative susceptibility mapping. PD patients had lower plasma serotonin (p < 0.0001) and higher nigral iron content (SNc: p < 0.001) overall. Exclusively in PD, lower plasma serotonin was correlated with higher nigral iron (SNc: r(58) = − 0.501, p < 0.001). This correlation was significant even in patients newly diagnosed (< 1 year) and stronger in the SNc than any other region examined. This study reveals an early, linear association between low serotonin and higher nigral iron in PD patients, which is absent in controls. This is consistent with a serotonin-iron relationship in the disease process, warranting further studies to determine its cause and directionality.

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Section: Discussionmentioning

confidence: 99%

Low plasma serotonin linked to higher nigral iron in Parkinson’s disease

Jellen

Lewis

et al. 2021

Sci Rep

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“…Serotonin then undergoes enzymatic breakdown primarily in the liver. The enzyme monoamine oxidase (MAO) converts serotonin into 5‐hydroxyindoleacetic acid (5‐HIAA), which is then excreted in the urine (Von Volkmann et al., 2019 ).…”

Section: Synthesis and Metabolism Of Serotoninmentioning

confidence: 99%

Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanisms

Akram,

Faisal,

Irfan

et al. 2023

Food Science & Nutrition

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Modulatory effects of serotonin (5‐Hydroxytryptamine [5‐HT]) have been seen in hepatic, neurological/psychiatric, and gastrointestinal (GI) disorders. Probiotics are live microorganisms that confer health benefits to their host. Recent research has suggested that probiotics can promote serotonin signaling, a crucial pathway in the regulation of mood, cognition, and other physiological processes. Reviewing the literature, we find that peripheral serotonin increases nutrient uptake and storage, regulates the composition of the gut microbiota, and is involved in mediating neuronal disorders. This review explores the mechanisms underlying the probiotic‐mediated increase in serotonin signaling, highlighting the role of gut microbiota in the regulation of serotonin production and the modulation of neurotransmitter receptors. Additionally, this review discusses the potential clinical implications of probiotics as a therapeutic strategy for disorders associated with altered serotonin signaling, such as GI and neurological disorders. Overall, this review demonstrates the potential of probiotics as a promising avenue for the treatment of serotonin‐related disorders and signaling of serotonin.

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Comparison of pre-analytical conditions for quantification of serotonin in platelet-poor plasma

Cited by 2 publications

References 11 publications

Low plasma serotonin linked to higher nigral iron in Parkinson’s disease

Low plasma serotonin linked to higher nigral iron in Parkinson’s disease

Exploring the serotonin‐probiotics‐gut health axis: A review of current evidence and potential mechanisms

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