Comparison of Pre-Emptive Pregabalin with Placebo and Diclofenac Combination for Postoperative Analgesia and Cognitive Functions After Laparoscopic Cholecystectomy

Akarsu, Tülin; Tür, Hülya; Bolat, Cihan; Ozkaynak, Ismail

doi:10.5336/medsci.2011-25368

Cited by 7 publications

(7 citation statements)

References 37 publications

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“…A pilot study by Leung et al. found that postoperative use of gabapentin decreased the incidence of delirium, and concluded that this was probably secondary to an opioid sparing effect .…”

Section: Discussionmentioning

confidence: 99%

The efficacy of peri‐operative interventions to decrease postoperative delirium in non‐cardiac surgery: a systematic review and meta‐analysis.

2014

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SummaryThe purpose of this meta-analysis was to determine the efficacy of peri-operative interventions in decreasing the incidence of postoperative delirium. An electronic search of four databases was conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were adhered to. We included randomised controlled trials of non-cardiac surgery with a peri-operative intervention and that reported postoperative delirium, and identified 29 trials. Meta-analysis revealed that peri-operative geriatric consultation (OR 0.46, 95% CI 0.32-0.67) and lighter anaesthesia (OR 2.66, 95% CI 1.27-5.56) were associated with a decreased incidence of postoperative delirium. For the other interventions, the point estimate suggested possible protection with prophylactic haloperidol (OR 0.62, 95% CI 0.36-1.05), bright light therapy (OR 0.20, 95% CI 0.03-1.19) and general as opposed to regional anaesthesia (OR 0.76,). This meta-analysis has shown that peri-operative geriatric consultations with multicomponent interventions and lighter anaesthesia are potentially effective in decreasing the incidence of postoperative delirium.

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“…A pilot study by Leung et al. found that postoperative use of gabapentin decreased the incidence of delirium, and concluded that this was probably secondary to an opioid sparing effect .…”

Section: Discussionmentioning

confidence: 99%

The efficacy of peri‐operative interventions to decrease postoperative delirium in non‐cardiac surgery: a systematic review and meta‐analysis.

2014

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“…27 Akarsu et al reported delayed recovery times with pregabalin, as a result of their study comparing 300 mg pregabalin with placebo-diclofenac combination in 60 patients. 28 In their study where the effects of different doses of pregabalin premedication on hemodynamic responses were evaluated, Rastogi et al found that there was no difference between groups in terms of recovery. 26 In our study, the distribution of the groups was similar in terms of operation time, recovery time and first analgesic initiation time.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication

Polat¹,

Kol²,

Avcı³

et al. 2019

Turkiye Klinikleri J Med Sci

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The studies about use of pregabalin for premedication have been recently carried out due to pregabalin has analgesic and anxiolytic effects together. We aimed to evaluate the effects of preoperative pregabalin on anxiety score, hemodynamic parameters, postoperative pain and analgesic consumption in patients undergoing elective abdominal hysterectomy. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The patients were randomly separated into 34 patients of two groups. This prospective randomized, double-blind and placebo-controlled study was performed in patients undergoing elective abdominal hysterectomy. Pregabalin 150 mg (Pregabalin Group) or placebo 150 mg empty capsule (Control Group) was given to the patients 12 hours and 1 hour before operation. STAI-I (State-Trait Anxiety Inventory-I) anxiety scale were performed to the patients during preoperative examination and 1 hour before operation. In both groups, intraoperative hemodynamic parameters, postoperative pain levels with VAS (Visual Analogue Scale), morphine consumption and developing side effects were recorded and analyzed. R Re es su ul lt ts s: : When all patients were compared from the point of demographic data, no difference was found between groups. STAI-I points were found significantly different between Pregabalin and Control groups both premedication and postmedication phases. MAP (Mean Arterial Pressure) data were found lower in pregabalin group at intraoperative 30 th , 40 th and 75 th minutes and postoperative 1 st minute (p<0.05). Postoperative VAS values were found lower in Pregabalin Group. Additional analgesic use and morphine consumption, were lower in Pregabalin group except 1 st and 30 th minutes. When both groups, examined with regard to side effects, side effect rates of Control Group were 29% and rates of Pregabalin Group were 10%. C Co on nc cl lu us si io on n: : In this study, it was concluded that pregabalin use at 12 and 1 hour before operation decreased preoperative anxiety score, provided postoperative analgesia and found superior to placebo due to decreasing side effects via decreasing the consumption of analgesics, however for the routine use of pregabalin in premedication it was needed further studies with different doses and large sample sizes.

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“…Yine Akarsu ve ark. [14] laparoskopik kolesistektomiden bir saat önce verilen 300 mg pregabalinin, ağrı ve analjezik tüketimini azalttığını bildirmişlerdir. Cabrera Schulmeyer ve ark.…”

Section: Discussionunclassified

“…Antinosiseptif etkisi, bu kanallar aracılığı ile kalsiyum girişinin ve takibinde primer afferent sinir liflerinden uyarıcı nörotransmitterlerin salınımının inhibisyonu ile oluşabilir. [13,14] Bu süreç, periferde ağrı olarak algılanan santral duyarlılığı azaltır. Bu alt ünitelere bağlanma afinitesi ve etki gücü gabapentinden altı kez daha fazladır.…”

Section: Discussionunclassified

“…[17,18] Dolayısı ile pregabalin ve gabapentin gibi antihiperaljezik ilaçlar ile cerrahi öncesinde santral duyarlılıkta sağlanan azalma, akut ve kronik ameliyat sonrası ağrıyı azaltabilir. [13,14,17,18] Preemptif analjezi, cerrahi travma sonrası ağrıya aşırı duyarlılığı azaltmak için, cerrahi öncesi uygulanır. Pregabalin hızlı etkilidir ve oral alımdan yaklaşık bir saat sonra maksimum plazma konsantrasyonuna ulaşır.…”

Section: Discussionunclassified

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The effects of pre-emptive pregabalin on post-thoracotomy pain and epidural analgesia

Tunç¹

2014

Turk Gogus Kalp Dama

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Bu çalışmada ameliyat öncesi tek doz oral pregabalinin, torakotomi ameliyatı geçiren ve epidural analjezi uygulanan hastalarda ameliyat sonrası ağrı, analjezik tüketimi ve yan etkiler üzerine etkisi araştırıldı. Ça lış m a pla nı: Ağustos 2009-Aralık 2009 tarihleri arasında kliniğimizde elektif torakotomi planlanan 40 hasta (34 erkek, 6 kadın; ort. yaş 49.5±13.8 yıl; dağılım 18-65 yıl) prospektif, randomize plasebo kontrollü, tek kör çalışma kapsamına alındı. Hastalar 20'şer kişilik iki gruba ayrıldı. Ameliyattan bir saat önce grup 1'e 150 mg oral pregabalin, grup 2'ye oral plasebo verildi. Ameliyat sonrası ağrı kontrolü için, hastaların tümüne torasik epidural hasta kontrollü analjezi (HKA) uygulandı. Ağrı skorları, epidural opioid kullanımı ve yan etkiler ameliyat sonrası 72 saat süresince kaydedildi. Hastalar ayrıca kronik torakotomi sonrası ağrı insidansı, şiddeti, allodini benzeri ağrı varlığı, ağrı şekli ve günlük yaşamı kısıtlaması açısından üçüncü ve altıncı aylarda değerlendirildi. Bul gu lar: Ağrı skorları grup 1'de HKA öncesinde, 1, 4, 12, 24, 48. ve 72. saatlerde grup 2'ye göre anlamlı derecede düşük idi (p<0.05). Epidural opioid tüketiminde azalma 0 ila 24. ve 48 ila 72. saatlerde grup 1'de grup 2'ye göre anlamlı derecede düşük idi (p<0.05). Grup 1'de kronik torakotomi sonrası ağrı insidansı, şiddeti ve günlük yaşamı kısıtlama Grup 2'ye göre üçüncü ayda istatistiksel olarak anlamlı derecede düşük idi (p<0.05). So nuç: Çalışmamız, torakotomi sonrası ağrı kontrolünde ameliyat öncesi uygulanan 150 mg tek doz oral pregabalinin; erken dönemde ağrı skorları ve epidural analjezik tüketimini azalttığını gösterdi. Pregabalin, ayrıca üçüncü ayda kronik torakotomi sonrası ağrı insidansı ve şiddetini düşürdü. Anah tar söz cük ler: Analjezi; kronik ağrı; epidural; ağrı; ameliyat sonrası; pregabalin; torakotomi. Background: This study aims to investigate the effects of preoperative single oral dose of pregabalin on postoperative pain, analgesic consumption and side effects in patients undergoing thoracotomy and receiving epidural analgesia. Methods: Between August 2009 and December 2009 40 patients (34 males, 6 females; mean age 49.5±13.8 years; range 18 to 65 years) who were scheduled for elective thoracotomy in our clinic were included in this prospective, randomized, placebocontrolled, single-blind study. The patients were divided into two groups each containing 20 patients. One hour before surgery, group 1 and group 2 received 150 mg oral pregabalin and oral placebo, respectively. Thoracic epidural patient-controlled analgesia (PCA) was administered in all patients for postoperative pain management. Pain scores, epidural opioid consumption and side effects were recorded for postoperative 72 hours. The patients were also assessed with respect to the incidence and severity of chronic postthoracotomy pain, the presence of allodynia-like pain and the limitation of daily life at three and six months. Results: Pain scores were significantly lower in group 1, compared to group 2 before PCA, at 1, 4, 12, 24, 48 and 72...

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Comparison of Pre-Emptive Pregabalin with Placebo and Diclofenac Combination for Postoperative Analgesia and Cognitive Functions After Laparoscopic Cholecystectomy

Cited by 7 publications

References 37 publications

The efficacy of peri‐operative interventions to decrease postoperative delirium in non‐cardiac surgery: a systematic review and meta‐analysis.

The efficacy of peri‐operative interventions to decrease postoperative delirium in non‐cardiac surgery: a systematic review and meta‐analysis.

Evaluation of Preoperative Anxiolytic and Postoperative Analgesic Effects of Pregabalin Premedication

The effects of pre-emptive pregabalin on post-thoracotomy pain and epidural analgesia

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