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A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : This study was conducted to evaluate the efficacy of pre-emptive pregabalin compared with plasebo and diclofenac combination for attenuating postoperative pain, analgesic consumption and cognitive function after laparoscopic cholecystectomy. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Sixty adults with ASA physical status I-III of either sex undergoing elective laparoscopic cholecystectomy were included in this prospective, randomized placebo controlled, single-blind study. Subjects were divided into two groups being 30 pat.ents in each to receive either a matching placebo or pregabalin 300 mg, administered orally 1 h before surgery. Intramuscular 75 mg diclofenac sodium was given to placebo patients 15-20 minutes before the estimated finishing time of surgery for pain relief after surgery. In the first 15 minutes after extubation, Aldrete Score and Ramsay Sedation Scale were evaluated. Mini mental test (MMT) was performed 1 hour and 6 hours after extubation. Postoperative pain was assessed by visual analogue scale (VAS). Time to first analgesic requirement, total analgesic dose and side effects were recorded. R Re es su ul lt ts s: : The difference between preoperative 1 st h and 6 th h MMT values was not statistically significant between the two groups. VAS scores were significantly higher in Group C compared to Group P (p <0.01). In Group P, the time to first analgesic rescue dose was significantly longer than in Group C (p<0.01). Total analgesic doses were significantly lower than in Group C patients (p<0.01). Sedation was significantly higher in Group P (p<0.05). C Co on nc cl lu us si io on n: : We conclude that administration of 300 mg of pregabalin 1 hour before surgery lengthens recovery time minimally, prolongs first analgesic requirement time, reduces total analgesic consumption and does not impair cognitive functions.K Ke ey y W Wo or rd ds s: : Cholecystectomy, laparoscopic; anesthesia recovery period; pain; delirium, dementia, amnestic, cognitive disorders Ö ÖZ ZE ET T A Am ma aç ç: : Preemptif pregabalinin plasebo ve diklofenak kombinasyonu ile karşılaştırıldığı laparoskopik kolesistektomi operasyonlarında, postoperatif ağrı, analjezik tüketimi ve bilişsel işlevler üzerindeki etkinliğinin değerlendirilmesi planlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Elektif laparoskopik kolesistektomi uygulanacak ASA I-III sınıfı 60 yetişkin olgu prospektif, randomize, plasebo kontrollü, tek kör çalışma kapsamına alındı. Olgular 30'ar kişilik iki gruba ayrıldı, cerrahiden bir saat önce oral olarak ya bir plasebo (Grup C) veya pregabalin (Grup P) 300 mg verildi. Plasebo alan hastalara tahmini ameliyat bitiminden 15-20 dakika önce intramüsküler 75 mg diklofenak sodyum verildi. Operasyon bitiminde, ekstübasyon saati, göz açma, komutlara yanıt verme ve oryantasyon zamanı kaydedildi. Ekstübasyondan sonra hastalar Aldrete ve Ramsey Sedasyon Skoru ile değerlendirildi. Ekstübasyondan 1 ve 6 saat sonra mini mental test (MMT) uygula...

A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Epidural anesthesia can be used successfully for lumbar disc surgery. Levobupivacaine,the S(-) isomer of bupivacaine, is less cardiotoxic than racemic bupivacaine. The aim of this study was to compare the clinical efficacy and safety of epidural anesthesia with levobupivacaine + fentanyl and bupivacaine + fentanyl in equivalent concentration and doses for elective lumbar laminectomy and discectomy. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Eighty ASA I-III cases undergoing lumbar laminectomy and discectomy were randomly divided into two groups. In the first group (Grup LF n=40) epidural block was achieved with 0.5% levobupivacaine (15 mL, 75 mg) + fentanyl 100 μg + 3 ml 0.9% NaCl solution, and in the second group (Grup BF n=40) 0.5% bupivacaine (15 mL, 75 mg) + fentanyl 100 μg + 3 ml 0.9% NaCl solution was used for epidural block . Surgery was started when sensory block reached to dermatomal level of T8. The onset time, and quality of sensory and motor block were evaluated. Blood pressure, heart rate, side effects and time to need for analgesic supplement (time to reach VAS 4) were recorded. R Re es su ul lt ts s: : Demographically both groups were similar. Onset of adequate sensory block (T8 dermatome) was similar in two groups (14.4 ± 5.9 min for Group LF, 11.4 ± 4.3 min for Group BF, respectively). Mean maximum block height was T5 in both groups (groupLF T2-T6 , group BF T4-T6). Complete regression of sensory block was significantly longer in group LF (296.7 ± 53.4 min) than Group BF (232.7 ± 37 min) (p<0.05). Motor block was evaluated by using modified Bromage scale. Degree of motor block in group LF was significantly lower than in group BF (p<0.05). The heart rate and mean arterial pressure values decreased in both groups but the decrease in group BF was significant between 30-60 min (p<0,05).The frequency of bradycardia and hypotension was higher in Group BF. C Co on nc cl lu us si io on n: : In conclusion, 0.375% levobupivacaine with fentanyl and 0.375% bupivacaine with fentanyl are suitable anesthetics for use in lumbar spine surgery but levobupivacaine provides less motor block and beter hemodynamic stability in comparison to bupivacaine. K Ke ey y W Wo or rd ds s: : Neurosurgery; discectomy; anesthesia, epidural; bupivacaine; levobupivacaine Ö ÖZ ZE ET T A Am ma aç ç: : Epi du ral anes te zi, lom ber disk cer ra hi si sı ra sın da ba şa rı lı bir se kil de uy gu lan mak ta dır. Bu ça lış manın ama cı, elek tif lom ber la mi nek to mi ve dis kek to mi ope ras yon la rın da epi du ral anes te zi de eşit doz ve kon santras yon da kul la nı lan le vo bu pi va ka in-fen ta nil ve bu pi va ka in-fen ta nil kom bi nas yon la rı nı kli nik et kin lik ve gü ve ni lir lik le ri açı sın dan kar şı laş tır mak tır. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Lom ber la mi nek to mi ve dis kek to mi uy gu la nacak ASA fi zik sel sko ru I-III olan 80 has ta ran do mi ze ola rak iki gru ba ay rıl dı. Epi du ral blok, le vo bu pi v...

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