Comparison of prevalence of anti-hepatitis C virus antibodies in differing South American populations

Robinson, John W.; Rosas, Marcela; Guzmán, Fanny; Patarroyo, Manuel Elkín; Moreno, Alberto

doi:10.1002/(sici)1096-9071(199610)50:2<188::aid-jmv13>3.0.co;2-i

Cited by 14 publications

(7 citation statements)

References 33 publications

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“…Our investigation is in agreement with previous work (118–121). However, our analysis was performed at the country level, rather than at the regional level, because of lack of adequate representative regional studies and the absence of surveillance programmes.…”

Section: Discussionsupporting

confidence: 94%

Trends and projections of hepatitis C virus epidemiology in Latin America

Kershenobich¹,

Razavi²,

Sánchez-Ávila³

et al. 2011

Liver International

132

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Background and aim: The purpose of the present investigation is to provide an analysis of previous works on the epidemiology of the hepatitis C virus (HCV) infection from six countries throughout Latin America, to forecast the future HCV prevalence trends in Argentina, Brazil, Mexico and Puerto Rico, and to outline deficiencies in available data, highlighting the need for further research. Methods: Data references were identified through indexed journals and non-indexed sources. Overall, 1080 articles were reviewed and 150 were selected based on their relevance to this work. When multiple data sources were available for a key assumption, a systematic process using multi-objective decision analysis (MODA) was used to select the most appropriate sources. When data were missing, analogues were used. Data from other countries with similar risk factors and/or population compositions were used as a proxy to help predict the future trends in prevalence. Results: The review indicates that the dominant genotype is type 1. HCV prevalence in the analysed countries ranges from 1 to 2.3%. The Latin American countries have been very proactive in screening their blood supplies, thus minimizing the risk of transmission through transfusion. This suggests that other risk factors are set to play a major role in continued new infections. The number of diagnosed and treated patients is low, thereby increasing the burden of complications such as liver cirrhosis or hepatocellular carcinoma. The HCV prevalence, according to our modelling is steady or increasing and the number of infected individuals will increase. Conclusions: The results herein reported should provide a foundation for informed planning efforts to tackle hepatitis.

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Section: Discussionsupporting

confidence: 94%

Trends and projections of hepatitis C virus epidemiology in Latin America

Kershenobich¹,

Razavi²,

Sánchez-Ávila³

et al. 2011

Liver International

132

View full text Add to dashboard Cite

show abstract

“…The prevalence of anti-HCV antibodies in the general European and Latin American population ranges between 0.5 and 2.5% [8,9,37,38] compared to 0.4% in our healthy control group. This discrepancy may be secondary to the younger age of our control group which does not account for the higher prevalence at older ages (i.e.…”

Section: Discussionmentioning

confidence: 51%

Prevalence of hepatitis C serum antibody in autoimmune diseases

Agmon‐Levin

Ram

Barzilai

et al. 2009

Journal of Autoimmunity

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“…El virus de la hepatitis C (HCV) está cdmpuesto ensayos diagnósticos para la detección de por un genoma de ARN de cadena simple con anticuerpos a estevirus (3)(4)(5)(6). Sin embargo, se ha .sentido positivo de aproximadamente 9.500 observado que las zonas cercanas a la región nucleótidos 19.4 kilobases\.…”

unclassified

“…La proteína estructural del núcleo (C) está altamente conservada y presenta una gran antigenicidad entre los diferentes aislamientos, de ahí la importancia de su incorporación en los Correspondencia: iqpeptidos@cie.sld.cu Recibido: 12/04/00; aceptado: 02/02/01 (3)(4)(5)(6).…”

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Evaluación de diferentes péptidos de la región estructural del virus de la hepatitis C

Gómez¹,

Hernández²,

Martínez³

et al. 2001

biomedica

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Para el diagnóstico del virus de la hepatitis C, se utilizan ampliamente las pruebas de Elisa por su sensibilidad y especificidad. Gran parte de ellos se basa en el empleo de péptidos sintéticos. Una de las zonas más conservadas y de gran antigenicidad es la región estructural del virus. En este estudio, se sintetizaron siete péptidos de zonas informadas como altamente antigénicas de la región estructural del virus de la hepatitis C. Los péptidos sintetizados representan la región del núcleo del virus. Se realizó la evaluación y comparación be los resultades de los péptidos sintetizados, para lo cual se emplearon muestraspos~tiva~ (n=72) y negativas (n=42). Con los péptidos más cercanos a la región amino terminal, la reactividad fue alta, pero fue disminuyendo a medida que nos acercabamos a la región carboxilo terminal. Estos resultadgs. . .-.region were synthesiz~d. Those peptides represent the itructural region bf the hepatitis C virus.~esults of synthesized peptides were tested and compared. Positive (n=72) and negative (n=42) sam~les were em~loved. Reactivitv was hiah in ue~tides closest to the N-terminus reaion and it decreased toward thé C-terminus ;egion. f h e res"lts coincide with other authors' resilts.

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Comparison of prevalence of anti-hepatitis C virus antibodies in differing South American populations

Cited by 14 publications

References 33 publications

Trends and projections of hepatitis C virus epidemiology in Latin America

Trends and projections of hepatitis C virus epidemiology in Latin America

Prevalence of hepatitis C serum antibody in autoimmune diseases

Evaluación de diferentes péptidos de la región estructural del virus de la hepatitis C

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