2003
DOI: 10.1542/peds.112.1.116
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Comparison of Propofol/Fentanyl Versus Ketamine/Midazolam for Brief Orthopedic Procedural Sedation in a Pediatric Emergency Department

Abstract: RT with P/F is shorter than with K/M. P/F is comparable to K/M in reducing procedural distress associated with painful orthopedic procedures in the pediatric emergency department. Although propofol has a greater potential of respiratory depression and airway obstruction as compared with ketamine, it offers some unique advantages including a quicker offset and smoother recovery profile.

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Cited by 178 publications
(129 citation statements)
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“…24 Godambe et al analyzed analgesia used on 113 children undergoing orthopedic procedures and found that both protocols (ketamine/midazolam vs. propofol/fentanyl) had similar results for the relief of pain and anxiety, although the propofol/fentanyl group presented a shorter procedure time. 2 In this study, the presence of hypoxemia was an unusual finding and there was significant difference between the groups who used ketamine or morphine. However, hypoxia is one of the adverse effects associated with the use of opioids cited most in the literature.…”
Section: Discussionmentioning
confidence: 54%
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“…24 Godambe et al analyzed analgesia used on 113 children undergoing orthopedic procedures and found that both protocols (ketamine/midazolam vs. propofol/fentanyl) had similar results for the relief of pain and anxiety, although the propofol/fentanyl group presented a shorter procedure time. 2 In this study, the presence of hypoxemia was an unusual finding and there was significant difference between the groups who used ketamine or morphine. However, hypoxia is one of the adverse effects associated with the use of opioids cited most in the literature.…”
Section: Discussionmentioning
confidence: 54%
“…6,10,27,28 In a systematic review of randomized trials of analgesia and sedation for reduction of fractures in children at a PEU, ketamine/ midazolam proved to be more effective as an analgesic and had fewer adverse effects than combinations of fentanyl/midazolam or propofol/midazolam. 1,2,4,5,15,25 When the level of satisfaction of parents and orthopedists were analyzed with analgesia for the orthopedic procedure, it was found that levels were quite high. Satisfaction was similar regardless of analgesic used, whether morphine or ketamine, a fact also described in other studies.…”
Section: Discussionmentioning
confidence: 99%
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