Comparison of protective effect of two types of aerobic and intermittent training on breast cancer by TGFβ protein and Smad-3 gene and MMP2 in female mice

Moghaddam, Vahaid; Peeri, Maghsoud; Azarbayjani, Mohammad Ali; Homaee, Hasan Matin

doi:10.18869/acadpub.hmj.21.1.53

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…The major target of TGFβ/Smad-3 is to prevent the processes of cell proliferation and growth (32,33). Therefore, increases in TGF-β/Smad-3 expression due to endurance trainings can increase inhibitory effects of this pathway and prevent cellular differentiation and tumor growth (34).…”

Section: Discussionmentioning

confidence: 99%

Interactive Effects of Exhaustive Exercise Training and Curcumin Supplementation on PDGF-BB and TGF-β1 Gene Expressions in Alcoholic Rats

2020

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Background and Objectives: Curcumin and exercise training are suggested to improve hepatic disorders. The aim of this study was to investigate effects of two weeks of swimming training and curcumin supplementation on platelet-derived growth factor (PDGF-BB) and transforming growth factor beta 1 (TGF-β1) gene expressions following ethanol consumption in Wistar male rats. Materials and Methods: Totally, 32 Wistar male rats were divided into four equal groups, including control, exercise, curcumin and curcumin-exercise groups. Ethanol was gavaged to all groups (g kg-1) for four days. Then, the renunciation period (four days) started. The exercise period included two weeks, each week included five sessions of exhaustive swimming. Curcumin supplementation (50 mg kg-1) was used with trainings. Results: Curcumin supplementation demonstrated significant decreases in expression of PDGF-BB (P = 0.025) and TGF-β1 (P = 0.033) genes. In exercise groups, significant decreases were seen in expression of PDGF-BB (P = 0.007) and TGF-β1 (P = 0.001) genes. Interaction of exercise and curcumin resulted in significant decreases in expression of PDGF-BB (P = 0.040) and TGF-β1 (P = 0.013) genes. Conclusions: In conclusion, expression decreases in PDGF-BB and TGF-β1 genes suggest that exercise and curcumin consumption can protect hepatic tissues through controlling hepatic satellite cell (HSC) activation, preventing negative effects of ethanol.

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Section: Discussionmentioning

confidence: 99%

Interactive Effects of Exhaustive Exercise Training and Curcumin Supplementation on PDGF-BB and TGF-β1 Gene Expressions in Alcoholic Rats

2020

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The effects of high-intensity interval training and saffron aqueous extract supplementation on alterations of body weight and apoptotic indices in skeletal muscle of 4T1 breast cancer-bearing mice with cachexia

Ahmadabadi

Saghebjoo

Huang

et al. 2020

Appl. Physiol. Nutr. Metab.

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Exercise training and antioxidant supplementation may improve unintentional weight loss and programmed cell death associated with cancer cachexia. The aim of this study was to examine the alterations of body weight and apoptotic indices in skeletal muscle of 4T1 breast cancer-bearing mice with cachexia following 4 weeks of high-intensity interval training (HIIT) and saffron aqueous extract (SAE) supplementation. Female BALB/c mice following induction of breast cancer were divided into (i) controls, (ii) HIIT, (iii) SAE, (iv) HIIT+SAE, and (v) sham groups. Mice were euthanized and gastrocnemius muscle was collected after intervention. The control group elicited a significant weight reduction during third and fourth weeks of tumor injection, while other treatments such as HIIT and SAE, but not HIIT+SAE, showed that they counteracted this adverse event. Furthermore, HIIT and SAE treatments (not HIIT+SAE) demonstrated reduced caspase-3 and Bax levels compared with the control group. The level of Bcl-2 was elevated following both HIIT and SAE treatments compared with the control group. Finally, the ratio of Bcl-2 to Bax was significantly higher in both HIIT and SAE groups, but was lower in HIIT+SAE group compared with sham group. It is likely that either HIIT or SAE intervention alone (not HIIT+SAE) represents a readily applicable approach in the regulation of muscle wasting and apoptosis in cancer cachexia. Novelty HIIT is associated with a reduced risk of cancer-related muscle wasting. SAE enhances the improvement of muscle loss and apoptotic indices. Combination of HIIT and SAE does not improve cancer-related loss of muscle mass and mediate apoptotic activation.

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Comparison of protective effect of two types of aerobic and intermittent training on breast cancer by TGFβ protein and Smad-3 gene and MMP2 in female mice

Abstract: Original Article AbstractIntroduction: The aim of this study was to compare the protective effects of two types of aerobic and intermittent training on breast cancer as a result of TGFβ protein, Smad-3, and MMP2 gene in female mice.

Cited by 2 publications

References 23 publications

Interactive Effects of Exhaustive Exercise Training and Curcumin Supplementation on PDGF-BB and TGF-β1 Gene Expressions in Alcoholic Rats

Interactive Effects of Exhaustive Exercise Training and Curcumin Supplementation on PDGF-BB and TGF-β1 Gene Expressions in Alcoholic Rats

The effects of high-intensity interval training and saffron aqueous extract supplementation on alterations of body weight and apoptotic indices in skeletal muscle of 4T1 breast cancer-bearing mice with cachexia

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